Regulating vesicle bilayer permeability and selectivity via stimuli-triggered polymersome-to-PICsome transition

• Published in: Nature communications Vol. 11; no. 1; pp. 1524 - 13
• Main Authors: Wang, Xiaorui, Yao, Chenzhi, Zhang, Guoying, Liu, Shiyong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.03.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 140/131; 140/58; 639/301/54/152; 639/301/923/1028; 639/301/923/966; Amines; Bilayers; Block copolymers; Chemical reactions; High temperature; Humanities and Social Sciences; Hydrogen bonding; Hydrophobicity; Ion pairs; Ionic strength; Ions; Liposomes; multidisciplinary; Permeability; pH effects; Polyelectrolytes; Science; Science (multidisciplinary); Selectivity; Sodium chloride; Stability; Stimuli; Ultraviolet radiation; Vesicles

Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically...