Regulating vesicle bilayer permeability and selectivity via stimuli-triggered polymersome-to-PICsome transition

Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically...

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Published inNature communications Vol. 11; no. 1; pp. 1524 - 13
Main Authors Wang, Xiaorui, Yao, Chenzhi, Zhang, Guoying, Liu, Shiyong
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 23.03.2020
Nature Publishing Group
Nature Portfolio
Subjects
140/131
140/58
639/301/54/152
639/301/923/1028
639/301/923/966
Amines
Bilayers
Block copolymers
Chemical reactions
High temperature
Humanities and Social Sciences
Hydrogen bonding
Hydrophobicity
Ion pairs
Ionic strength
Ions
Liposomes
multidisciplinary
Permeability
pH effects
Polyelectrolytes
Science
Science (multidisciplinary)
Selectivity
Sodium chloride
Stability
Stimuli
Ultraviolet radiation
Vesicles
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Abstract Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically relevant ionic strength and temperature; moreover, permselectivity tuning of PICsomes has remained a challenge. Starting from a single component diblock or triblock precursor, we solve this dilemma by stimuli-triggered chemical reactions within pre-organized BCP vesicles, actuating in situ polymersome-to-PICsome transition and achieving molecular size-selective cargo release at tunable rates. UV light and reductive milieu were utilized to trigger carboxyl decaging and generate ion pairs within hydrophobic polymersome bilayers containing tertiary amines. Contrary to conventional PICsomes, in situ generated ones are highly stable towards extreme pH range (pH 2-12), ionic strength (~3 M NaCl), and elevated temperature (70 °C) due to multivalent ion-pair interactions at high local concentration and cooperative hydrogen bonding interactions of pre-organized carbamate linkages. Polyion complex vesicles have advantageous applications but have poorly tuneable permeability and nanostructure stability. Here, the authors develop polyion complex vesicles created using a stimuli-triggered transition from polymersomes and show high stability and switchable bilayer permaselectivity.
AbstractList Polyion complex vesicles have advantageous applications but have poorly tuneable permeability and nanostructure stability. Here, the authors develop polyion complex vesicles created using a stimuli-triggered transition from polymersomes and show high stability and switchable bilayer permaselectivity.
Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically relevant ionic strength and temperature; moreover, permselectivity tuning of PICsomes has remained a challenge. Starting from a single component diblock or triblock precursor, we solve this dilemma by stimuli-triggered chemical reactions within pre-organized BCP vesicles, actuating in situ polymersome-to-PICsome transition and achieving molecular size-selective cargo release at tunable rates. UV light and reductive milieu were utilized to trigger carboxyl decaging and generate ion pairs within hydrophobic polymersome bilayers containing tertiary amines. Contrary to conventional PICsomes, in situ generated ones are highly stable towards extreme pH range (pH 2-12), ionic strength (~3 M NaCl), and elevated temperature (70 °C) due to multivalent ion-pair interactions at high local concentration and cooperative hydrogen bonding interactions of pre-organized carbamate linkages. Polyion complex vesicles have advantageous applications but have poorly tuneable permeability and nanostructure stability. Here, the authors develop polyion complex vesicles created using a stimuli-triggered transition from polymersomes and show high stability and switchable bilayer permaselectivity.
Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically relevant ionic strength and temperature; moreover, permselectivity tuning of PICsomes has remained a challenge. Starting from a single component diblock or triblock precursor, we solve this dilemma by stimuli-triggered chemical reactions within pre-organized BCP vesicles, actuating in situ polymersome-to-PICsome transition and achieving molecular size-selective cargo release at tunable rates. UV light and reductive milieu were utilized to trigger carboxyl decaging and generate ion pairs within hydrophobic polymersome bilayers containing tertiary amines. Contrary to conventional PICsomes, in situ generated ones are highly stable towards extreme pH range (pH 2-12), ionic strength (~3 M NaCl), and elevated temperature (70 °C) due to multivalent ion-pair interactions at high local concentration and cooperative hydrogen bonding interactions of pre-organized carbamate linkages.
Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically relevant ionic strength and temperature; moreover, permselectivity tuning of PICsomes has remained a challenge. Starting from a single component diblock or triblock precursor, we solve this dilemma by stimuli-triggered chemical reactions within pre-organized BCP vesicles, actuating in situ polymersome-to-PICsome transition and achieving molecular size-selective cargo release at tunable rates. UV light and reductive milieu were utilized to trigger carboxyl decaging and generate ion pairs within hydrophobic polymersome bilayers containing tertiary amines. Contrary to conventional PICsomes, in situ generated ones are highly stable towards extreme pH range (pH 2-12), ionic strength (~3 M NaCl), and elevated temperature (70 °C) due to multivalent ion-pair interactions at high local concentration and cooperative hydrogen bonding interactions of pre-organized carbamate linkages.Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically relevant ionic strength and temperature; moreover, permselectivity tuning of PICsomes has remained a challenge. Starting from a single component diblock or triblock precursor, we solve this dilemma by stimuli-triggered chemical reactions within pre-organized BCP vesicles, actuating in situ polymersome-to-PICsome transition and achieving molecular size-selective cargo release at tunable rates. UV light and reductive milieu were utilized to trigger carboxyl decaging and generate ion pairs within hydrophobic polymersome bilayers containing tertiary amines. Contrary to conventional PICsomes, in situ generated ones are highly stable towards extreme pH range (pH 2-12), ionic strength (~3 M NaCl), and elevated temperature (70 °C) due to multivalent ion-pair interactions at high local concentration and cooperative hydrogen bonding interactions of pre-organized carbamate linkages.
Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex vesicles (PICsomes) from oppositely charged block polyelectrolytes possess semipermeable bilayers, they are unstable towards physiologically relevant ionic strength and temperature; moreover, permselectivity tuning of PICsomes has remained a challenge. Starting from a single component diblock or triblock precursor, we solve this dilemma by stimuli-triggered chemical reactions within pre-organized BCP vesicles, actuating in situ polymersome-to-PICsome transition and achieving molecular size-selective cargo release at tunable rates. UV light and reductive milieu were utilized to trigger carboxyl decaging and generate ion pairs within hydrophobic polymersome bilayers containing tertiary amines. Contrary to conventional PICsomes, in situ generated ones are highly stable towards extreme pH range (pH 2-12), ionic strength (~3 M NaCl), and elevated temperature (70 °C) due to multivalent ion-pair interactions at high local concentration and cooperative hydrogen bonding interactions of pre-organized carbamate linkages.Polyion complex vesicles have advantageous applications but have poorly tuneable permeability and nanostructure stability. Here, the authors develop polyion complex vesicles created using a stimuli-triggered transition from polymersomes and show high stability and switchable bilayer permaselectivity.
ArticleNumber 1524
Author Zhang, Guoying
Yao, Chenzhi
Wang, Xiaorui
Liu, Shiyong
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PublicationDate_xml – month: 03
  year: 2020
  text: 2020-03-23
  day: 23
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
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Snippet Compared to liposomes, polymersomes of block copolymers (BCPs) possess enhanced stability, along with compromised bilayer permeability. Though polyion complex...
Polyion complex vesicles have advantageous applications but have poorly tuneable permeability and nanostructure stability. Here, the authors develop polyion...
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StartPage 1524
SubjectTerms 140/131
140/58
639/301/54/152
639/301/923/1028
639/301/923/966
Amines
Bilayers
Block copolymers
Chemical reactions
High temperature
Humanities and Social Sciences
Hydrogen bonding
Hydrophobicity
Ion pairs
Ionic strength
Ions
Liposomes
multidisciplinary
Permeability
pH effects
Polyelectrolytes
Science
Science (multidisciplinary)
Selectivity
Sodium chloride
Stability
Stimuli
Ultraviolet radiation
Vesicles
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Title Regulating vesicle bilayer permeability and selectivity via stimuli-triggered polymersome-to-PICsome transition
URI https://link.springer.com/article/10.1038/s41467-020-15304-x
https://www.ncbi.nlm.nih.gov/pubmed/32251282
https://www.proquest.com/docview/2382034079
https://www.proquest.com/docview/2387253295
https://pubmed.ncbi.nlm.nih.gov/PMC7090076
https://doaj.org/article/e1cc7424682647beba0cc81503c472b9
Volume 11
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