Remodeling characteristics and collagen distribution in synthetic mesh materials explanted from human subjects after abdominal wall reconstruction: an analysis of remodeling characteristics by patient risk factors and surgical site classifications

• Published in: Surgical endoscopy Vol. 28; no. 6; pp. 1852 - 1865
• Main Authors: Cavallo, Jaime A., Roma, Andres A., Jasielec, Mateusz S., Ousley, Jenny, Creamer, Jennifer, Pichert, Matthew D., Baalman, Sara, Frisella, Margaret M., Matthews, Brent D., Deeken, Corey R.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2014; Springer Nature B.V
• Subjects: Abdomen; Abdominal Surgery; Abdominal Wall - pathology; Abdominal Wall - surgery; Adult; Aged; Aged, 80 and over; Biopsy; Blood vessels; Body mass index; Collagen; Collagen - analysis; Extracellular matrix; Extracellular Matrix - chemistry; Extracellular Matrix - pathology; Female; Fibrosis - etiology; Fibrosis - pathology; Gastroenterology; Gynecology; Hepatology; Hernias; Human subjects; Humans; Inflammation - etiology; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Neovascularization, Pathologic - etiology; Neovascularization, Pathologic - pathology; Pathogens; Proctology; Prostheses and Implants - adverse effects; Reconstructive Surgical Procedures - adverse effects; Risk Factors; Surgery; Surgical Mesh - adverse effects; Synthetic products; Tissue Distribution; St Louis Missouri; United States > US; Sirius red/fast green; Surgical site infection; Hernia repair; Abdominal wall reconstruction; Synthetic mesh remodeling; Contamination

Background The purpose of this study was to evaluate the associations between patient characteristics or surgical site classifications and the histologic remodeling scores of synthetic meshes biopsied from their abdominal wall repair sites in the first attempt to generate a multivariable risk predic...