Molecular characterization of cell-free eccDNAs in human plasma

• Published in: Scientific reports Vol. 7; no. 1; pp. 10968 - 11
• Main Authors: Zhu, Jing, Zhang, Fan, Du, Meijun, Zhang, Peng, Fu, Songbin, Wang, Liang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.09.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 3' Untranslated regions; 45/77; 631/114/2785; 631/208/211; 631/208/514/2254; Base Composition; Biomarkers - blood; Blood & organ donations; Cell-Free Nucleic Acids - blood; Cell-Free Nucleic Acids - chemistry; Cell-Free Nucleic Acids - genetics; Circular DNA; Deoxyribonuclease; Deoxyribonucleic acid; DNA; DNA sequencing; DNA, Circular - blood; DNA, Circular - chemistry; DNA, Circular - genetics; Exons; Humanities and Social Sciences; Humans; Molecular modelling; multidisciplinary; Nucleotide Motifs; Peripheral blood; Science; Science (multidisciplinary); Size distribution

Extrachromosomal circular DNAs (eccDNAs) have been reported in most eukaryotes. However, little is known about the cell-free eccDNA profiles in circulating system such as blood. To characterize plasma cell-free eccDNAs, we performed sequencing analysis in 26 libraries from three blood donors and neg...