CYP6AE gene cluster knockout in Helicoverpa armigera reveals role in detoxification of phytochemicals and insecticides

• Published in: Nature communications Vol. 9; no. 1; pp. 4820 - 8
• Main Authors: Wang, Huidong, Shi, Yu, Wang, Lu, Liu, Shuai, Wu, Shuwen, Yang, Yihua, Feyereisen, René, Wu, Yidong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.11.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 45/70; 631/158/2452; 631/601/1466; 82/80; Agricultural ecosystems; Agricultural management; Animals; Base Sequence; Cotton; CRISPR; CRISPR-Associated Protein 9 - genetics; CRISPR-Associated Protein 9 - metabolism; CRISPR-Cas Systems; Cytochrome P-450 Enzyme System - deficiency; Cytochrome P-450 Enzyme System - genetics; Detoxification; Embryo, Nonmammalian; Female; Gene Editing - methods; Gene Expression; Genes; Genetics; Genome editing; Genome, Insect; Genomes; Helicoverpa armigera; Host plants; Humanities and Social Sciences; Inactivation, Metabolic - genetics; Insect Proteins - deficiency; Insect Proteins - genetics; Insecticide resistance; Insecticide Resistance - genetics; Insecticides; Insecticides - metabolism; Insecticides - pharmacology; Insects; Larva - drug effects; Larva - enzymology; Larva - genetics; Larva - growth & development; Lethal Dose 50; Male; Metabolism; Moths - drug effects; Moths - enzymology; Moths - genetics; Moths - growth & development; multidisciplinary; Multigene Family; Mutation; Organic chemistry; Pesticide resistance; Pests; Phytochemicals; Reverse Genetics; RNA, Guide, CRISPR-Cas Systems - genetics; RNA, Guide, CRISPR-Cas Systems - metabolism; Science; Science (multidisciplinary); Survival; Toxins; Xenobiotics

The cotton bollworm Helicoverpa armigera , is one of the world’s major pest of agriculture, feeding on over 300 hosts in 68 plant families. Resistance cases to most insecticide classes have been reported for this insect. Management of this pest in agroecosystems relies on a better understanding of h...