CRISPR/Cas9 therapeutics: progress and prospects

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and effici...

Full description

Saved in:
Bibliographic Details
Published inSignal transduction and targeted therapy Vol. 8; no. 1; pp. 36 - 23
Main Authors Li, Tianxiang, Yang, Yanyan, Qi, Hongzhao, Cui, Weigang, Zhang, Lin, Fu, Xiuxiu, He, Xiangqin, Liu, Meixin, Li, Pei-feng, Yu, Tao
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.01.2023
Nature Publishing Group
Subjects
631/61/2300
692/4017
Cancer Research
Cell Biology
Clinical trials
CRISPR
CRISPR-Cas Systems - genetics
Disease
Gene Editing
Genetic Therapy - methods
Genome editing
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Pathology
Review
Review Article
Online AccessGet full text

Cover

Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. A variety of efficient Cas9 variants and derivatives have been developed to cope with the complex genomic changes that occur during diseases. However, strategies to effectively deliver the CRISPR system to diseased cells in vivo are currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset are expected to serve as identifying factors for targeted delivery or targets for gene editing. Diseases are both varied and complex, and the choice of appropriate gene-editing methods and delivery vectors for different diseases is important. Meanwhile, there are still many potential challenges identified when targeting delivery of CRISPR/Cas9 technology for disease treatment. This paper reviews the current developments in three aspects, namely, gene-editing type, delivery vector, and disease characteristics. Additionally, this paper summarizes successful examples of clinical trials and finally describes possible problems associated with current CRISPR applications.
AbstractList Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. A variety of efficient Cas9 variants and derivatives have been developed to cope with the complex genomic changes that occur during diseases. However, strategies to effectively deliver the CRISPR system to diseased cells in vivo are currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset are expected to serve as identifying factors for targeted delivery or targets for gene editing. Diseases are both varied and complex, and the choice of appropriate gene-editing methods and delivery vectors for different diseases is important. Meanwhile, there are still many potential challenges identified when targeting delivery of CRISPR/Cas9 technology for disease treatment. This paper reviews the current developments in three aspects, namely, gene-editing type, delivery vector, and disease characteristics. Additionally, this paper summarizes successful examples of clinical trials and finally describes possible problems associated with current CRISPR applications.
Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. A variety of efficient Cas9 variants and derivatives have been developed to cope with the complex genomic changes that occur during diseases. However, strategies to effectively deliver the CRISPR system to diseased cells in vivo are currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset are expected to serve as identifying factors for targeted delivery or targets for gene editing. Diseases are both varied and complex, and the choice of appropriate gene-editing methods and delivery vectors for different diseases is important. Meanwhile, there are still many potential challenges identified when targeting delivery of CRISPR/Cas9 technology for disease treatment. This paper reviews the current developments in three aspects, namely, gene-editing type, delivery vector, and disease characteristics. Additionally, this paper summarizes successful examples of clinical trials and finally describes possible problems associated with current CRISPR applications.
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. A variety of efficient Cas9 variants and derivatives have been developed to cope with the complex genomic changes that occur during diseases. However, strategies to effectively deliver the CRISPR system to diseased cells in vivo are currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset are expected to serve as identifying factors for targeted delivery or targets for gene editing. Diseases are both varied and complex, and the choice of appropriate gene-editing methods and delivery vectors for different diseases is important. Meanwhile, there are still many potential challenges identified when targeting delivery of CRISPR/Cas9 technology for disease treatment. This paper reviews the current developments in three aspects, namely, gene-editing type, delivery vector, and disease characteristics. Additionally, this paper summarizes successful examples of clinical trials and finally describes possible problems associated with current CRISPR applications.Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by permanently correcting deleterious base mutations or disrupting disease-causing genes with great precision and efficiency. A variety of efficient Cas9 variants and derivatives have been developed to cope with the complex genomic changes that occur during diseases. However, strategies to effectively deliver the CRISPR system to diseased cells in vivo are currently lacking, and nonviral vectors with target recognition functions may be the focus of future research. Pathological and physiological changes resulting from disease onset are expected to serve as identifying factors for targeted delivery or targets for gene editing. Diseases are both varied and complex, and the choice of appropriate gene-editing methods and delivery vectors for different diseases is important. Meanwhile, there are still many potential challenges identified when targeting delivery of CRISPR/Cas9 technology for disease treatment. This paper reviews the current developments in three aspects, namely, gene-editing type, delivery vector, and disease characteristics. Additionally, this paper summarizes successful examples of clinical trials and finally describes possible problems associated with current CRISPR applications.
ArticleNumber 36
Author Li, Pei-feng
Yang, Yanyan
Liu, Meixin
He, Xiangqin
Cui, Weigang
Qi, Hongzhao
Li, Tianxiang
Zhang, Lin
Fu, Xiuxiu
Yu, Tao
Author_xml – sequence: 1
  givenname: Tianxiang
  surname: Li
  fullname: Li, Tianxiang
  organization: Institute for Translational Medicine, The Affiliated Hospital of Qingdao University
– sequence: 2
  givenname: Yanyan
  surname: Yang
  fullname: Yang, Yanyan
  organization: Department of Immunology, School of Basic Medicine, Qingdao University
– sequence: 3
  givenname: Hongzhao
  surname: Qi
  fullname: Qi, Hongzhao
  organization: Institute for Translational Medicine, The Affiliated Hospital of Qingdao University
– sequence: 4
  givenname: Weigang
  surname: Cui
  fullname: Cui, Weigang
  organization: Department of Cardiology, People’s Hospital of Rizhao
– sequence: 5
  givenname: Lin
  surname: Zhang
  fullname: Zhang, Lin
  organization: Department of Microbiology, Linyi Center for Disease Control and Prevention
– sequence: 6
  givenname: Xiuxiu
  surname: Fu
  fullname: Fu, Xiuxiu
  organization: Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University
– sequence: 7
  givenname: Xiangqin
  surname: He
  fullname: He, Xiangqin
  organization: Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University
– sequence: 8
  givenname: Meixin
  surname: Liu
  fullname: Liu, Meixin
  organization: Institute for Translational Medicine, The Affiliated Hospital of Qingdao University
– sequence: 9
  givenname: Pei-feng
  orcidid: 0000-0002-0969-9407
  surname: Li
  fullname: Li, Pei-feng
  email: peifli@qdu.edu.cn
  organization: Institute for Translational Medicine, The Affiliated Hospital of Qingdao University
– sequence: 10
  givenname: Tao
  surname: Yu
  fullname: Yu, Tao
  email: yutao0112@qdu.edu.cn
  organization: Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36646687$$D View this record in MEDLINE/PubMed
BookMark eNp9Ustu1DAUtVARLaU_wAKNxIZN6L1-xWaBhEY8RqoEKrC2HMeeZpSJBztB4u9xmlLaLrry65xzz70-z8nREAdPyEuEtwhMnWeOTNMKKKsAGeiqfkJOKAhdMcnE0Z39MTnLeQcAKFldC_6MHDMpuZSqPiGwvtx8_3Z5vrZZr8Yrn-zBT2Pn8rvVIcVt8jmv7NDOh3zwbswvyNNg--zPbtZT8vPTxx_rL9XF18-b9YeLykmQYxWk1tYjZcCpsDQ4bZtGtErXyAUKGlrwgVuBCFyhZxAa9OAoRRmCRmSnZLPottHuzCF1e5v-mGg7c30R09bYVIz23oQg6sBKTxQpR-0a1zrLwCpKHWdKFq33i9Zhava-dX4Yk-3vid5_Gbors42_jVYcBcwCb24EUvw1-TyafZed73s7-DhlQ-syUAYK6wJ9_QC6i1MayqhmlFBKKj139-quo1sr_z6mAOgCcGXwOflwC0EwcwDMEgBTAmCuA2BmknpAct1oxy7OXXX941S2UHOpM2x9-m_7EdZfLz7Bng
CitedBy_id crossref_primary_10_1016_j_jbc_2024_105685
crossref_primary_10_3390_ijms25073984
crossref_primary_10_1007_s10142_024_01404_0
crossref_primary_10_3390_biomedicines12122716
crossref_primary_10_7759_cureus_50031
crossref_primary_10_3390_ijms241914701
crossref_primary_10_1007_s40259_024_00654_5
crossref_primary_10_3390_genes15121653
crossref_primary_10_1007_s10068_023_01481_0
crossref_primary_10_1016_j_earlhumdev_2024_106130
crossref_primary_10_1002_smll_202405231
crossref_primary_10_1016_j_ymthe_2024_11_012
crossref_primary_10_3389_fgeed_2023_1230424
crossref_primary_10_5409_wjcp_v13_i3_98468
crossref_primary_10_1007_s00284_024_03875_7
crossref_primary_10_1002_wsbm_1630
crossref_primary_10_1007_s11033_024_09801_1
crossref_primary_10_3389_fgene_2023_1273994
crossref_primary_10_1007_s11064_024_04311_9
crossref_primary_10_1016_j_ijpharm_2025_125295
crossref_primary_10_1038_s41598_024_58094_8
crossref_primary_10_3339_ckd_25_008
crossref_primary_10_1002_adma_202412366
crossref_primary_10_1039_D4MH01158A
crossref_primary_10_3389_fgene_2024_1434002
crossref_primary_10_1016_j_ijbiomac_2024_134775
crossref_primary_10_7717_peerj_17402
crossref_primary_10_1007_s12010_023_04850_x
crossref_primary_10_1016_j_microc_2024_112577
crossref_primary_10_3390_venereology3040015
crossref_primary_10_1002_biot_202300298
crossref_primary_10_37349_ei_2024_00161
crossref_primary_10_1007_s11033_024_10052_3
crossref_primary_10_18231_j_ijmmtd_2024_003
crossref_primary_10_1038_s41598_024_70075_5
crossref_primary_10_1080_17576180_2024_2437418
crossref_primary_10_11144_Javeriana_SC291_gewc
crossref_primary_10_1097_MS9_0000000000001500
crossref_primary_10_1002_advs_202401797
crossref_primary_10_1016_j_visres_2023_108273
crossref_primary_10_1039_D4CS00404C
crossref_primary_10_1016_j_intimp_2023_111297
crossref_primary_10_1039_D4SC05157B
crossref_primary_10_3389_fchem_2023_1259435
crossref_primary_10_51335_organoid_2024_4_e12
crossref_primary_10_1007_s12033_024_01301_8
crossref_primary_10_1016_j_theriogenology_2024_10_025
crossref_primary_10_1016_j_jconrel_2024_12_015
crossref_primary_10_1016_j_ygeno_2024_110836
crossref_primary_10_1016_j_jsb_2024_108070
crossref_primary_10_1016_j_hpj_2024_02_012
crossref_primary_10_1186_s12864_024_11039_x
crossref_primary_10_3390_biom13101534
crossref_primary_10_1134_S0026893324700249
crossref_primary_10_1016_j_biopha_2024_117003
crossref_primary_10_1016_j_gene_2024_148865
crossref_primary_10_1002_advs_202308095
crossref_primary_10_1007_s00203_025_04262_x
crossref_primary_10_1016_j_jbc_2024_108120
crossref_primary_10_1002_adfm_202402630
crossref_primary_10_1016_j_xpro_2024_103123
crossref_primary_10_4049_jimmunol_2300642
crossref_primary_10_1021_acsnano_4c07750
crossref_primary_10_1161_CIRCRESAHA_124_323800
crossref_primary_10_1016_j_nantod_2025_102654
crossref_primary_10_47115_bsagriculture_1263027
crossref_primary_10_3390_ijms252212346
crossref_primary_10_2174_0113816128344571241018154506
crossref_primary_10_1016_j_ijpharm_2024_123845
crossref_primary_10_1016_j_ijbiomac_2023_129150
crossref_primary_10_4103_IJO_IJO_2902_23
crossref_primary_10_1021_acs_biomac_4c00925
crossref_primary_10_1002_advs_202403858
crossref_primary_10_1016_j_fsigen_2024_103163
crossref_primary_10_1111_jcmm_70051
crossref_primary_10_1038_s41598_024_57551_8
crossref_primary_10_3389_fimmu_2024_1479483
crossref_primary_10_1007_s40242_025_4243_5
crossref_primary_10_1016_j_aquaculture_2025_742355
crossref_primary_10_1016_j_fct_2023_113653
crossref_primary_10_1038_s41392_024_01905_1
crossref_primary_10_1016_j_pharmthera_2024_108774
crossref_primary_10_3390_ijms241713241
crossref_primary_10_3390_biom14111393
crossref_primary_10_3389_fmed_2024_1527600
crossref_primary_10_1002_cmdc_202400791
crossref_primary_10_1038_s41420_023_01556_1
crossref_primary_10_1097_GH9_0000000000000182
crossref_primary_10_3390_ijms241512317
crossref_primary_10_1002_adtp_202400412
crossref_primary_10_1016_j_jddst_2024_105338
crossref_primary_10_5662_wjm_v15_i2_101458
crossref_primary_10_1002_pdi3_16
crossref_primary_10_1016_j_chroma_2024_465523
crossref_primary_10_1007_s00344_024_11395_8
crossref_primary_10_59786_bmtj_221
crossref_primary_10_3390_ijms24098173
crossref_primary_10_1016_j_ejphar_2025_177368
crossref_primary_10_2174_0115665232275754231204072320
crossref_primary_10_2147_DDDT_S500276
crossref_primary_10_24075_brsmu_2024_074
crossref_primary_10_3389_fmicb_2024_1483527
crossref_primary_10_3390_ijms25020823
crossref_primary_10_1089_nat_2023_0068
crossref_primary_10_3390_su162310587
crossref_primary_10_4103_ANT_33_4_Review
crossref_primary_10_1007_s12026_024_09536_y
crossref_primary_10_1016_j_lfs_2024_122897
crossref_primary_10_2174_0115665232266508231210154930
crossref_primary_10_3390_md22040159
crossref_primary_10_1021_acsnano_4c15173
crossref_primary_10_3389_fimmu_2023_1347401
crossref_primary_10_1016_j_chembiol_2023_12_011
crossref_primary_10_1007_s12032_025_02647_y
crossref_primary_10_1038_s41598_025_85334_2
crossref_primary_10_1002_biot_202300352
crossref_primary_10_3390_v15122395
crossref_primary_10_1016_j_tips_2025_02_009
crossref_primary_10_3390_ijms242216161
crossref_primary_10_1016_j_pharmthera_2024_108764
crossref_primary_10_1016_j_envres_2023_116333
crossref_primary_10_1016_j_lfs_2023_122006
crossref_primary_10_3389_fmolb_2023_1308274
crossref_primary_10_3390_fermentation9100874
crossref_primary_10_1016_j_mimet_2024_107066
crossref_primary_10_3390_ijms25179299
crossref_primary_10_3390_molecules29092073
crossref_primary_10_1016_j_chembiol_2024_05_005
crossref_primary_10_1002_smll_202400069
crossref_primary_10_3390_plants12233961
crossref_primary_10_1007_s12038_023_00415_6
crossref_primary_10_1002_wnan_1938
crossref_primary_10_1097_ACO_0000000000001343
crossref_primary_10_1021_acssynbio_3c00596
crossref_primary_10_1172_JCI183836
crossref_primary_10_2147_IJN_S424872
crossref_primary_10_1016_j_future_2024_05_029
crossref_primary_10_1186_s40164_024_00580_w
crossref_primary_10_3390_ijms26020472
crossref_primary_10_1002_cmdc_202300359
crossref_primary_10_1093_plphys_kiae526
crossref_primary_10_1208_s12249_024_02802_0
crossref_primary_10_3390_pharmaceutics15102431
crossref_primary_10_1038_s41587_024_02467_x
crossref_primary_10_1134_S1068162024040046
crossref_primary_10_1016_j_bioactmat_2024_11_002
crossref_primary_10_3390_biology13100802
crossref_primary_10_1111_imm_13884
crossref_primary_10_1016_j_jddst_2024_106589
crossref_primary_10_1007_s40123_023_00729_6
crossref_primary_10_1002_smsc_202400447
crossref_primary_10_3390_vaccines12060636
crossref_primary_10_1016_j_bmcl_2024_129815
crossref_primary_10_1039_D4CB00116H
crossref_primary_10_1016_j_phrs_2023_106932
crossref_primary_10_1089_hum_2023_102
crossref_primary_10_1186_s12951_024_02427_2
crossref_primary_10_1016_j_drudis_2023_103793
crossref_primary_10_1097_MS9_0000000000001692
crossref_primary_10_1016_j_ejphar_2024_176584
crossref_primary_10_1016_j_joi_2024_101548
crossref_primary_10_3389_fgene_2024_1375481
crossref_primary_10_3390_medicina60091384
crossref_primary_10_1007_s12033_025_01368_x
crossref_primary_10_1039_D4PY00298A
crossref_primary_10_1002_jex2_156
crossref_primary_10_3390_ijms25042364
crossref_primary_10_1016_j_isci_2024_109502
crossref_primary_10_3390_molecules29194737
crossref_primary_10_5713_ab_24_0206
crossref_primary_10_1109_RBME_2024_3494715
crossref_primary_10_1038_s41587_023_01744_5
crossref_primary_10_1210_endrev_bnae002
crossref_primary_10_2174_0115665232306205240419091414
crossref_primary_10_1007_s10555_024_10188_5
crossref_primary_10_51847_wv4pyDAtfP
crossref_primary_10_1002_adtp_202400126
crossref_primary_10_1016_j_jddst_2024_105607
crossref_primary_10_1021_acs_jpcb_4c08265
crossref_primary_10_3390_synbio3010004
crossref_primary_10_1007_s11033_023_08986_1
crossref_primary_10_3390_biomedicines12081725
crossref_primary_10_3390_ijms26051965
crossref_primary_10_1016_j_heliyon_2024_e39538
crossref_primary_10_1002_advs_202308763
crossref_primary_10_1016_j_arcmed_2024_103124
crossref_primary_10_1007_s44307_024_00010_2
crossref_primary_10_3390_ijms241814057
crossref_primary_10_1186_s12967_024_05570_4
crossref_primary_10_1016_j_cell_2024_04_031
crossref_primary_10_3390_ijms252413321
crossref_primary_10_1016_j_bbcan_2024_189233
crossref_primary_10_1016_j_injury_2024_111976
crossref_primary_10_1038_s41467_025_56048_w
crossref_primary_10_1016_j_jconrel_2024_12_062
crossref_primary_10_3390_pharmaceutics16070918
crossref_primary_10_1016_j_jconrel_2023_09_032
crossref_primary_10_3390_biomedicines13020365
crossref_primary_10_3390_jcm13133977
crossref_primary_10_1038_s42003_024_06001_2
crossref_primary_10_3389_fphys_2024_1347888
crossref_primary_10_1007_s12035_024_04239_9
crossref_primary_10_1021_acs_analchem_3c05133
crossref_primary_10_1016_j_cclet_2024_109875
crossref_primary_10_1039_D4BM00286E
crossref_primary_10_1016_j_plgene_2024_100476
crossref_primary_10_1186_s12951_024_02554_w
crossref_primary_10_1002_mco2_767
crossref_primary_10_31857_S0132342324040147
crossref_primary_10_1016_j_lfs_2024_123120
crossref_primary_10_1016_j_surfin_2025_106096
crossref_primary_10_1208_s12249_024_03010_6
crossref_primary_10_1007_s00438_024_02166_x
crossref_primary_10_31857_S0026898424040044
crossref_primary_10_3389_fmed_2024_1356578
crossref_primary_10_1002_advs_202402178
crossref_primary_10_3390_cells13121052
crossref_primary_10_1080_14786419_2024_2416512
crossref_primary_10_1016_j_apsb_2024_04_015
crossref_primary_10_3390_genes16010075
crossref_primary_10_1080_09205063_2024_2445376
crossref_primary_10_1007_s11154_023_09860_y
crossref_primary_10_1016_j_fmre_2024_11_006
crossref_primary_10_1016_j_gene_2024_149075
crossref_primary_10_1016_j_bbrc_2024_150942
crossref_primary_10_1093_nar_gkae401
crossref_primary_10_37489_2949_1924_0023
crossref_primary_10_1186_s12964_024_01713_8
crossref_primary_10_1002_adma_202404645
crossref_primary_10_1186_s12864_024_10625_3
Cites_doi 10.1038/ncomms13331
10.1126/science.1231143
10.1016/j.ijfoodmicro.2008.05.030
10.3201/eid0502.990210
10.1093/nar/gkr606
10.1016/j.semcancer.2018.04.001
10.1111/jcmm.16500
10.1016/j.omtn.2016.11.004
10.1038/s41573-019-0017-4
10.1016/j.cell.2010.03.016
10.1016/j.drudis.2018.02.001
10.1038/nrmicro2577
10.1016/j.tibtech.2016.06.008
10.1126/science.1159689
10.1016/j.addr.2020.06.026
10.1016/j.cell.2014.09.014
10.1038/s41586-022-04470-1
10.1002/adma.202003537
10.1038/nmeth.2598
10.1038/nature16526
10.1016/S0169-409X(01)00211-3
10.1212/WNL.0000000000012965
10.1016/j.jconrel.2021.07.032
10.1161/CIRCULATIONAHA.119.044444
10.1073/pnas.1001673107
10.1111/cge.13589
10.1038/mt.2015.71
10.1038/s41467-018-07322-7
10.1146/annurev-biophys-062215-010822
10.1038/nature13011
10.1038/s41587-020-0412-8
10.1099/mic.0.28048-0
10.1126/science.aba7365
10.1002/wnan.1609
10.1016/j.tibtech.2018.08.002
10.1038/s41392-022-01151-3
10.1016/j.biomaterials.2020.120094
10.1002/tcr.202000087
10.1038/ni.2001
10.1016/j.jconrel.2015.07.019
10.1038/cr.2013.157
10.1093/nar/gkw159
10.1007/s10741-019-09776-3
10.1038/s41586-022-05114-0
10.1038/s41586-018-0380-z
10.1016/j.cell.2020.04.011
10.3390/ijms23179862
10.1038/nm.3910
10.15252/embj.201796474
10.1073/pnas.1512503112
10.1016/j.jconrel.2022.08.042
10.1016/j.tibtech.2013.04.004
10.1021/jacs.8b11996
10.1016/j.cell.2020.10.025
10.1016/j.molcel.2018.12.003
10.1093/nar/gkt076
10.1038/nature14592
10.1038/s41576-018-0059-1
10.1038/nmeth.3993
10.1002/hep.30677
10.1146/annurev-arplant-050718-100049
10.1038/srep26269
10.1038/s41586-019-1711-4
10.1093/mp/sst119
10.1126/science.aaq0180
10.1126/science.aax7063
10.1016/j.ymthe.2022.07.018
10.1016/j.stem.2013.10.016
10.1371/journal.pcbi.0010060
10.3390/ijms22083902
10.1126/science.1225829
10.1002/hep.30807
10.1038/s41587-019-0168-1
10.1016/j.apsb.2021.01.004
10.1016/j.biotechadv.2013.08.015
10.1126/science.aaf5573
10.1093/nar/gkz184
10.1038/cr.2017.16
10.1007/s00239-004-0046-3
10.1016/j.celrep.2013.06.020
10.1161/CIRCRESAHA.118.314522
10.1371/journal.pbio.3000747
10.1099/mic.0.27437-0
10.1101/gr.171322.113
10.1056/NEJMoa2029392
10.1016/j.bj.2019.10.005
10.1126/science.aau0629
10.1093/rb/rbab033
10.1146/annurev-genet-071719-022559
10.1038/nsmb.3486
10.1089/crispr.2021.0076
10.1080/17425247.2018.1517746
10.1126/science.1258096
10.1016/j.molcel.2019.09.030
10.1038/s41586-021-03609-w
10.1038/nrd.2016.246
10.1038/s41589-020-0490-4
10.1038/s41579-020-00468-6
10.5483/BMBRep.2017.50.1.128
10.1128/JB.01412-07
10.1038/s41576-021-00408-x
10.1038/s41591-019-0401-y
10.3389/fbioe.2019.00164
10.1038/nrm.2015.2
10.1038/s41467-022-28900-w
10.1126/science.1165409
10.1002/anie.202005644
10.1016/j.jmb.2015.10.014
10.1038/s41587-020-0561-9
10.1136/jnnp-2014-308724
10.1128/jb.169.12.5429-5433.1987
10.1158/1078-0432.CCR-18-3496
10.1016/j.cell.2015.09.038
10.1002/anie.201708689
10.1038/nbt.4066
10.1016/j.biomaterials.2020.120225
10.3389/fmed.2021.649896
10.1038/s41467-020-17411-1
10.1126/sciadv.aba5614
10.1038/s41591-018-0209-1
10.1038/nm.2700
10.1016/j.jpba.2020.113642
10.1038/s41591-018-0327-9
10.1038/nbt.3199
10.1038/nbt.4172
10.1161/CIR.0000000000000351
10.1016/j.cell.2021.09.018
10.1007/s00335-010-9275-5
10.1016/j.jare.2021.07.001
10.1038/s41573-020-00091-3
10.1002/jmv.24270
10.1038/nbt.4194
10.1016/j.ymthe.2020.07.021
10.1186/s13045-021-01169-0
10.1038/s41594-019-0258-2
10.1038/nature08703
10.1016/j.ccell.2018.03.012
10.1093/nar/gkaa1251
10.1039/D1BM01658J
10.3390/ijms22116072
10.1016/j.cell.2015.12.035
10.1038/aps.2017.178
10.1021/acssynbio.8b00192
10.1126/science.aav9023
10.1038/nmeth.3312
10.1016/j.actbio.2020.12.057
10.1038/s41573-020-0090-8
10.1126/science.aam9321
10.1021/acsami.1c21595
10.1016/S0140-6736(17)31822-6
10.1038/nature15544
10.1016/j.addr.2021.03.009
10.1016/j.biomaterials.2021.120965
10.1038/s41588-021-00838-7
10.1534/genetics.113.156737
10.1016/j.jgg.2013.12.004
10.1038/nature22398
10.5483/BMBRep.2021.54.2.217
10.1021/acs.nanolett.8b02689
10.1126/science.aaf8729
10.1093/nar/gkf417
10.1038/s41596-021-00669-0
10.1002/advs.202002499
10.1016/j.ymthe.2020.11.030
10.1111/j.1365-2958.1995.mmi_17010085.x
10.1126/science.aad5227
10.1038/nm.3793
10.1126/science.1138140
10.1016/j.addr.2020.03.001
10.1038/s41587-022-01377-0
10.1038/nsmb.3344
10.1200/JCO.2010.32.2537
10.1016/j.addr.2019.11.005
10.1002/hep.30766
10.1016/j.ymthe.2019.11.029
10.1016/j.addr.2021.113891
10.1038/nature19802
10.1038/nature09886
10.1002/anie.202107036
10.1111/pbi.13232
10.1016/j.cell.2013.02.022
10.1038/s41587-020-0453-z
10.1016/j.jconrel.2020.06.032
10.1002/advs.201900386
10.1016/j.addr.2021.114108
10.1016/S0140-6736(20)32542-3
10.1016/j.cell.2013.08.021
10.1016/bs.acr.2018.05.001
10.1016/j.ymthe.2019.07.002
10.1161/CIRCRESAHA.114.300507
10.1126/sciadv.abc9450
10.1016/S1074-7613(00)80089-8
10.1016/j.jacc.2020.07.061
10.1016/j.celrep.2021.110196
10.1016/j.ymthe.2022.07.001
10.1016/j.jconrel.2022.02.018
10.1038/s41586-022-04585-5
10.1038/nbt.2623
10.1101/gr.171264.113
10.1126/sciadv.abp9435
10.1038/nrd3978
10.1371/journal.pone.0040913
10.1038/nature24268
10.3390/ijms21186461
10.1016/j.biotechadv.2016.12.003
10.1111/j.1365-2958.1993.tb00976.x
10.1016/j.biotechadv.2019.107447
10.1056/NEJMoa1716153
10.7150/thno.62449
10.1073/pnas.1208507109
10.1002/hep.30422
10.1136/bmj.i4098
10.1002/hep.25736
10.1016/j.molp.2020.12.017
10.1038/s41467-018-05477-x
10.1007/s00018-009-8739-9
10.1126/science.aas9129
10.1126/science.aba8853
10.7150/thno.47007
10.1038/s41598-018-20505-y
10.1016/j.cell.2020.03.023
10.1038/s41392-021-00631-2
10.1002/adma.201905751
10.1038/s41594-018-0051-7
10.1002/smll.201907301
10.1016/j.bios.2020.112752
10.1073/pnas.1318481110
10.1146/annurev-biochem-013118-111902
10.1126/science.1232033
10.1002/jev2.12076
10.1021/acsnano.8b05151
10.1038/s41591-020-0840-5
10.1101/gr.246900.118
10.1016/j.cell.2014.09.039
10.1056/NEJMc2026172
10.1016/j.cell.2017.06.012
10.1038/s41467-020-20633-y
10.1016/j.yjmcc.2022.06.003
10.1038/s41467-020-19821-7
10.1128/JB.01415-07
10.1016/j.tplants.2018.03.003
10.1016/j.ymthe.2021.05.010
10.1084/jem.20171626
10.1016/j.drup.2018.11.001
10.1016/j.cmi.2021.10.005
10.1016/j.cell.2013.06.044
10.1039/D1BM01124C
10.1002/adma.201802896
10.1016/j.ijpharm.2021.120405
10.1056/NEJMoa2107454
10.1186/s13045-022-01237-z
10.1182/blood-2018-01-791400
10.1016/j.omtm.2020.12.001
10.1146/annurev-pathmechdis-012419-032626
10.1038/nature13579
10.1038/s41467-021-26518-y
10.1038/s41580-019-0131-5
10.1038/nprot.2013.132
10.1038/s41421-018-0069-3
10.1126/science.1256996
10.1016/j.stem.2013.11.002
10.1016/j.cell.2014.05.010
10.1093/nar/gkaa269
10.1038/nature16933
10.1016/j.omtm.2020.09.001
10.1002/smll.202007593
10.1016/j.stemcr.2015.08.001
10.1021/bi0522394
10.1038/s41587-020-0609-x
10.1093/cvr/cvz250
10.1002/anie.200800963
10.1126/science.aab1452
10.1093/nar/gkt442
10.1038/s41569-018-0119-4
10.1002/advs.201902312
10.1016/j.tifs.2022.02.030
10.1007/s00018-022-04175-8
10.1002/adma.201902575
10.1038/nature14136
10.3390/ijms22010397
10.1038/nature17946
10.1016/j.apsb.2021.05.020
10.1080/10717544.2020.1850917
10.1038/s41467-022-31322-3
10.1371/journal.pbio.0040204
10.1021/jacs.7b11754
10.1073/pnas.1402597111
10.2147/IJN.S279094
10.1038/s41565-019-0591-y
10.3389/fnmol.2020.00168
10.1056/NEJMoa2031054
10.1080/2162402X.2016.1249558
10.1016/j.jhep.2021.08.011
10.1038/s41551-019-0502-4
10.1016/bs.pmbts.2020.12.018
10.1038/nature26155
10.1517/14712598.2015.1057563
10.1093/nar/gkt780
10.1126/sciadv.aao4774
10.1073/pnas.0801763105
10.1038/s41593-017-0060-6
10.1111/j.1600-065X.2008.00722.x
10.1038/s41569-022-00683-z
10.1038/nature17945
10.1016/j.tplants.2019.09.006
10.1038/s42003-018-0035-5
10.7150/ijbs.62506
10.1016/j.ymthe.2018.03.010
10.1038/s41587-020-0572-6
10.1016/j.talanta.2020.121634
10.1177/0300985817738095
10.1128/CMR.00228-20
10.1038/nprot.2013.143
10.1016/j.cell.2013.04.025
10.1073/pnas.84.21.7413
10.1093/nar/gkv1222
10.1016/j.jare.2020.10.003
10.1073/pnas.1906843116
10.1038/nm.2128
10.1016/j.cell.2016.01.039
10.1038/s41587-019-0095-1
10.1038/nrn.2015.2
10.1016/j.cell.2014.02.001
10.1038/s41587-020-0592-2
10.1038/nature24644
10.1038/nbt.3404
10.1073/pnas.2020401118
10.1126/sciadv.abj0624
10.1016/j.cell.2016.08.056
10.1016/j.jacc.2019.07.076
10.1016/j.it.2020.10.004
10.1016/j.neuron.2018.05.008
10.1038/s41577-018-0103-6
10.1038/nature24049
10.1016/j.canlet.2018.05.042
10.1016/0167-4781(96)00040-1
10.1515/ntrev-2022-0095
10.1016/j.jacc.2019.07.063
10.1002/advs.201801423
10.1161/CIRCRESAHA.119.315408
10.1073/pnas.1619926114
10.1186/gb-2008-9-6-229
10.1046/j.1365-2958.2000.01838.x
10.1016/j.cell.2018.11.052
10.1038/cr.2014.160
10.1186/s12951-021-01233-4
10.3390/cells10081931
10.1038/s41587-022-01410-2
ContentType Journal Article
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7T5
7X7
7XB
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
COVID
DWQXO
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.1038/s41392-023-01309-7
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Immunology Abstracts
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
Coronavirus Research Database
ProQuest Central
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Biological Science Collection
ProQuest Health & Medical Collection
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
AIDS and Cancer Research Abstracts
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Coronavirus Research Database
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef

MEDLINE - Academic

MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 2059-3635
EndPage 23
ExternalDocumentID oai_doaj_org_article_ff57f3366212419cbcdca30a822c4386
PMC9841506
36646687
10_1038_s41392_023_01309_7
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GrantInformation_xml – fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 81870331
  funderid: https://doi.org/10.13039/501100001809
– fundername: Qingdao Municipal Science and Technology Bureau
  grantid: No.21-1-4-rkjk-12-nsh
  funderid: https://doi.org/10.13039/501100010870
– fundername: Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
  grantid: ZR2021MH280
  funderid: https://doi.org/10.13039/501100007129
– fundername: ;
  grantid: 81870331
– fundername: ;
  grantid: ZR2021MH280
– fundername: ;
  grantid: No.21-1-4-rkjk-12-nsh
GroupedDBID 0R~
3V.
5VS
7X7
8FI
8FJ
AAJSJ
ABUWG
ACGFS
ACSMW
ADBBV
AFKRA
AJTQC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
EBLON
EBS
EJD
EMOBN
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HYE
M7P
NAO
OK1
PIMPY
PQQKQ
PROAC
RNT
RPM
SNYQT
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7XB
8FE
8FH
8FK
AARCD
AZQEC
COVID
DWQXO
GNUQQ
H94
K9.
LK8
PKEHL
PQEST
PQGLB
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c606t-f699ae1230425a2fc9abb5d897145152fd0ef4a5110481e30fb1e0c2216ff9113
IEDL.DBID 7X7
ISSN 2059-3635
2095-9907
IngestDate Wed Aug 27 01:23:55 EDT 2025
Thu Aug 21 18:39:19 EDT 2025
Wed Jul 30 10:30:13 EDT 2025
Wed Aug 13 04:19:40 EDT 2025
Thu Apr 03 06:58:12 EDT 2025
Thu Apr 24 23:06:55 EDT 2025
Tue Jul 01 03:15:17 EDT 2025
Fri Feb 21 02:39:06 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c606t-f699ae1230425a2fc9abb5d897145152fd0ef4a5110481e30fb1e0c2216ff9113
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-0969-9407
OpenAccessLink https://www.proquest.com/docview/2765886891?pq-origsite=%requestingapplication%
PMID 36646687
PQID 2765886891
PQPubID 2041911
PageCount 23
ParticipantIDs doaj_primary_oai_doaj_org_article_ff57f3366212419cbcdca30a822c4386
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9841506
proquest_miscellaneous_2766430817
proquest_journals_2765886891
pubmed_primary_36646687
crossref_primary_10_1038_s41392_023_01309_7
crossref_citationtrail_10_1038_s41392_023_01309_7
springer_journals_10_1038_s41392_023_01309_7
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-01-16
PublicationDateYYYYMMDD 2023-01-16
PublicationDate_xml – month: 01
  year: 2023
  text: 2023-01-16
  day: 16
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Signal transduction and targeted therapy
PublicationTitleAbbrev Sig Transduct Target Ther
PublicationTitleAlternate Signal Transduct Target Ther
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Wan (CR128) 2022; 8
Fiolet (CR286) 2022; 28
Adams (CR302) 2018; 379
Behr, Zhou, Xu, Zhang (CR29) 2021; 11
Wang (CR228) 2018; 57
Pegtel, Gould (CR213) 2019; 88
Anzalone, Koblan, Liu (CR172) 2020; 38
Edraki (CR328) 2019; 73
Ran (CR22) 2013; 8
Kleinstiver (CR112) 2015; 33
Derks, Bergmann (CR273) 2020; 126
Gong (CR257) 2020; 32
Chen, Alphonse, Liu (CR32) 2020; 12
Ibraheim (CR329) 2021; 12
Kim (CR125) 2014; 24
Groenen, Bunschoten, van Soolingen, van Embden (CR35) 1993; 10
Nahmad (CR320) 2022; 40
Wojnilowicz (CR349) 2019; 13
Chen (CR348) 2021; 6
Komor (CR160) 2017; 3
Li (CR243) 2021; 11
Gasiunas, Barrangou, Horvath, Siksnys (CR48) 2012; 109
Babuta (CR215) 2019; 70
CR291
Klum (CR95) 2018; 37
Zhi (CR245) 2020; 325
Paul, Montoya (CR136) 2020; 43
Newby (CR18) 2021; 595
Li (CR278) 2021; 17
Jahromi (CR334) 2021; 8
Abudayyeh (CR81) 2017; 550
Wu (CR296) 2019; 25
Bhardwaj (CR283) 2022; 40
Esrick (CR297) 2021; 384
Hoe (CR37) 1999; 5
Nevzorova (CR218) 2012; 56
Cong (CR340) 2022; 182
Hirano (CR111) 2016; 164
Nussenzweig, Nussenzweig (CR99) 2010; 141
Manghwar, Lindsey, Zhang, Jin (CR2) 2019; 24
Villiger (CR262) 2018; 24
Cai, Luo, Mao, Wang (CR33) 2021; 60
Makarova (CR50) 2011; 9
Aliyari, Ding (CR45) 2009; 227
Sameiyan (CR203) 2021; 123
Casini (CR102) 2018; 36
Zhang (CR207) 2019; 31
Pickar-Oliver, Gersbach (CR7) 2019; 20
Zhang, Shen, Li, Cheng (CR312) 2021; 11
Heidenreich, Zhang (CR19) 2016; 17
Mojica, Ferrer, Juez, Rodríguez-Valera (CR36) 1995; 17
Li (CR244) 2021; 60
Li (CR10) 2021; 14
Yang (CR258) 2021; 75
Hsu, Lander, Zhang (CR5) 2014; 157
Schwank (CR70) 2013; 13
Lee (CR201) 2008; 47
Majumder (CR241) 2021; 20
Lee (CR161) 2021; 54
Liu (CR235) 2019; 31
Zhao (CR178) 2020; 16
Madsen (CR277) 2020; 142
Bendle (CR251) 2010; 16
Gratton (CR337) 2008; 105
Mao (CR134) 2022; 122
Chung (CR285) 2019; 29
Jiang, Doudna (CR14) 2017; 46
Wu (CR68) 2013; 13
Horvath (CR44) 2008; 190
Li (CR141) 2022; 170
Richter (CR164) 2020; 38
Rapoport (CR249) 2015; 21
Jinek (CR47) 2012; 337
Nishimasu (CR51) 2014; 156
Tang (CR335) 2021; 8
Su (CR83) 2017; 6
Rigopoulos (CR299) 2019; 24
Sternberg, LaFrance, Kaplan, Doudna (CR93) 2015; 527
Sonntag, Schmidt, Kleinschmidt (CR185) 2010; 107
Robbins (CR248) 2011; 29
Kleinstiver (CR342) 2016; 529
Konermann (CR146) 2015; 517
Stadtmauer (CR247) 2020; 367
Sekijima (CR301) 2015; 86
Yang, Chen, Shi (CR212) 2019; 31
Frangoul (CR74) 2021; 384
Kim (CR80) 2020; 181
Huang (CR166) 2019; 37
Sousa, Coelho, Taipa (CR300) 2021; 97
Collias, Beisel (CR326) 2021; 12
Xiao (CR97) 2017; 170
Nishida (CR167) 2016; 353
Liu (CR314) 2020; 11
CR113
Xu (CR311) 2021; 168
Nguyen (CR192) 2021; 275
Mirjalili Mohanna (CR198) 2022; 350
Yang (CR129) 2020; 21
Villamizar (CR72) 2019; 27
Witzigmann (CR194) 2020; 159
Brouns (CR46) 2008; 321
Chavez (CR145) 2015; 12
Fu (CR21) 2021; 49
Liu (CR202) 2021; 11
Ishino (CR34) 1987; 169
Lee (CR101) 2018; 9
Schumann (CR124) 2015; 112
Singh (CR315) 2018; 25
Rupaimoole, Slack (CR239) 2017; 16
Taher, Weatherall, Cappellini (CR293) 2018; 391
Zhang (CR280) 2019; 6
Sankaran (CR295) 2008; 322
Shteinberg, Haq, Polineni, Davies (CR71) 2021; 397
Thommen, Schumacher (CR246) 2018; 33
Platt (CR13) 2014; 159
Chen (CR103) 2017; 550
Stella, Alcón, Montoya (CR135) 2017; 546
Beane (CR84) 2015; 23
Landrum (CR23) 2016; 44
Burton (CR307) 2019; 19
Wang, Zhang, Gao (CR30) 2020; 181
Yang (CR234) 2019; 141
Liu (CR206) 2019; 6
Akinc (CR305) 2019; 14
Ran (CR131) 2013; 154
Maule, Ensinck, Bulcaen, Carlon (CR73) 2021; 182
Li (CR255) 2022; 7
Chandrasegaran, Carroll (CR88) 2016; 428
Li (CR177) 2020; 48
Yüce, Filiztekin, Özkaya (CR289) 2021; 172
Ma (CR65) 2014; 24
Ramakrishna (CR126) 2014; 24
Luther (CR121) 2018; 15
Barrangou (CR42) 2007; 315
Békési, Holub, Pálinkás, Vértessy (CR157) 2021; 22
Hilton (CR149) 2015; 33
Kleinstiver (CR341) 2015; 523
Zhu (CR270) 2020; 76
Zhang, Hu (CR263) 2015; 87
Schuster (CR175) 2019; 37
Luo (CR261) 2021; 28
Luk, Zhang (CR230) 2015; 220
Deveau (CR43) 2008; 190
Tamay (CR210) 2019; 7
Marraffini, Sontheimer (CR9) 2010; 463
Masepohl, Görlitz, Böhme (CR38) 1996; 1307
Yao (CR127) 2021; 10
Slaymaker (CR343) 2016; 351
Stevens (CR272) 2016; 354
Tanenbaum (CR148) 2014; 159
Chew (CR187) 2016; 13
Tan (CR108) 2019; 116
Javaid, Pham, Choi (CR325) 2021; 22
Gootenberg (CR182) 2017; 356
Harrison, Lin, Wang (CR287) 2020; 41
Qi (CR24) 2013; 152
Zhang (CR238) 2022; 38
Wilson, Chen, Miao, Liu (CR176) 2020; 38
Tang, Zhao, Jiang (CR86) 2021; 168
Zhao (CR75) 2021; 39
Bratovič (CR107) 2020; 16
Hu (CR240) 2021; 14
Bolotin, Quinquis, Sorokin, Ehrlich (CR11) 2005; 151
Lu (CR82) 2020; 26
Youn, Chung (CR122) 2015; 15
Cha (CR242) 2019; 76
Gaudelli (CR26) 2017; 551
Leibowitz (CR331) 2021; 53
Zhan (CR16) 2019; 55
Qi (CR256) 2022; 11
Chen (CR12) 2019; 70
Liu (CR150) 2016; 167
Gerard (CR170) 2002; 30
Huang (CR225) 2021; 17
Zhang, Zhang, Unver, Zhang (CR98) 2021; 29
Gu (CR274) 2016; 7
Schoger (CR276) 2020; 126
Doudna, Charpentier (CR15) 2014; 346
Himeda, Jones, Jones (CR139) 2021; 20
Mancuso (CR310) 2020; 11
Cox, Platt, Zhang (CR6) 2015; 21
Xu (CR336) 2021; 176
Vojta (CR151) 2016; 44
Cox (CR179) 2017; 358
Li (CR237) 2022; 14
Magadán, Dupuis, Villion, Moineau (CR57) 2012; 7
Liu (CR232) 2021; 337
Jiang (CR92) 2015; 348
Gaj, Gersbach, Barbas (CR4) 2013; 31
Jiang (CR66) 2013; 41
Dominguez, Lim, Qi (CR143) 2016; 17
Lee (CR165) 2018; 9
Alsaiari (CR204) 2018; 140
Brandow, Liem (CR294) 2022; 15
Piepenburg, Williams, Stemple, Armes (CR183) 2006; 4
Moradpour, Abdulah (CR323) 2020; 18
Koblan (CR159) 2018; 36
Zetsche (CR133) 2015; 163
Bose (CR231) 2018; 23
Hansson, Hermansson (CR267) 2011; 12
Di Maria (CR140) 2020; 13
Zhao (CR181) 2018; 431
Wang (CR264) 2022; 20
Hsu (CR281) 2020; 28
Xie, Yang (CR67) 2013; 6
Qie (CR338) 2016; 6
Zischewski, Fischer, Bortesi (CR316) 2017; 35
Qiu (CR195) 2021; 118
Reshke (CR216) 2020; 4
Safiabadi Tali (CR290) 2021; 34
Lopes (CR226) 2021; 223
Lin, Haga, Zeng, Estes (CR189) 2022; 17
Böhm (CR188) 2020; 6
Ali, Mahas, Mahfouz (CR77) 2018; 23
Szczelkun (CR91) 2014; 111
Anders, Niewoehner, Duerst, Jinek (CR327) 2014; 513
Mojica, Díez-Villaseñor, Soria, Juez (CR39) 2000; 36
Zhao (CR265) 2019; 16
Kwan (CR219) 2020; 71
Bai (CR279) 2021; 25
Abudayyeh (CR28) 2016; 353
Oakes (CR109) 2019; 176
Cui (CR208) 2018; 41
Matharu (CR284) 2019; 363
Anzalone (CR27) 2019; 576
Yan (CR233) 2021; 7
Walton, Christie, Whittaker, Kleinstiver (CR117) 2020; 368
Jiang, Meng, Yang, Luo (CR1) 2020; 97
Yin (CR110) 2022; 13
DeRossi (CR221) 2019; 70
Vermersch, Jouve, Hulot (CR17) 2020; 116
Zheng (CR168) 2018; 1
Noy (CR309) 2019; 134
Chen (CR217) 2019; 69
Zhao (CR69) 2010; 21
Wright, Nuñez, Doudna (CR52) 2016; 164
East-Seletsky (CR78) 2016; 538
Romeo (CR196) 2009; 119
Aimo (CR303) 2022; 19
Sternberg (CR90) 2014; 507
Wu (CR229) 2021; 598
Yang, Xu, Ge, Lai (CR40) 2021; 8
Mehta (CR269) 2016; 133
S, Mäger, Breakefield, Wood (CR211) 2013; 12
Adikusuma (CR333) 2018; 560
Hu (CR116) 2018; 556
Liu (CR120) 2019; 47
Shen (CR130) 2017; 50
Liao, Beisel (CR85) 2021; 55
Sung (CR190) 2013; 41
Stella, Alcón, Montoya (CR137) 2017; 24
Larson (CR254) 2022; 604
Noack (CR275) 2019; 74
Setten, Rossi, Han (CR174) 2019; 18
Tachibana, Harashima, Shinohara, Kiwada (CR119) 2001; 52
Backstrom (CR186) 2020; 19
Wang (CR64) 2013; 153
Rosenblum (CR199) 2020; 6
Wen (CR298) 2022; 30
Pacesa (CR94) 2022; 609
Teng (CR292) 2018; 4
Chuai, Wang, Liu (CR87) 2017; 35
Zafra (CR158) 2018; 36
Gao (CR171) 2022; 30
Hsu (CR344) 2020; 252
Li, Lin, Jiang, Yu (CR214) 2018; 39
Li (CR266) 2022; 30
Kunz, Saito, Schär (CR156) 2009; 66
Lainšček (CR220) 2018; 7
Becirovic (CR321) 2022; 79
Oka, Akazawa, Naito, Komuro (CR268) 2014; 114
Ren (CR60) 2013; 110
Jeong, Song, Bae (CR155) 2020; 28
Haft, Selengut, Mongodin, Nelson (CR49) 2005; 1
Manghwar (CR100) 2020; 7
Conticello (CR153) 2008; 9
Wu (CR20) 2015; 25
Chen (CR173) 2021; 184
Lin (CR282) 2018; 98
Wu (CR260) 2018; 8
Cong (CR56) 2013; 339
Bassett, Liu (CR63) 2014; 41
Lu (CR191) 2013; 31
Nishimasu (CR115) 2018; 361
Li (CR222) 2019; 19
Bartneck (CR259) 2021; 173
Mitchell (CR200) 2021; 20
Pourcel, Salvignol, Vergnaud (CR41) 2005; 151
Gillmore (CR31) 2021; 385
Tadros (CR271) 2019; 74
Lu (CR169) 2022; 23
Sedic (CR197) 2018; 55
Zhang (CR209) 2020; 256
Provasi (CR252) 2012; 18
Abudayyeh (CR180) 2019; 365
V’Kovski (CR79) 2021; 19
Larson (CR147) 2013; 8
Kondo, Ueda (CR61) 2013; 195
Fan, Marioli, Zhang (CR345) 2021; 192
Zuo (CR105) 2022; 5
Peng (CR227) 2021; 9
Wienert (CR317) 2019; 364
Lin, Wagner, Lächelt (CR118) 2022; 10
Mojica, Díez-Villaseñor, García-Martínez, Soria (CR8) 2005; 60
Gilbert (CR59) 2013; 154
Seki, Rutz (CR123) 2018; 215
Fonfara (CR138) 2016; 532
Perrin, Rousseau, Tremblay (CR350) 2017; 6
Rees, Liu (CR154) 2018; 19
Tao (CR288) 2021; 22
Xie (CR106) 2020; 18
Roth, Marson (CR3) 2021; 16
Mekler, Minakhin, Severinov (CR89) 2017; 114
Dianov, Hübscher (CR132) 2013; 41
Amina, Guo (CR224) 2020; 15
Nowicki (CR250) 2019; 25
Connor, Broome (CR223) 2018; 139
Mulepati, Héroux, Bailey (CR96) 2014; 345
Dad (CR339) 2021; 29
Kurt (CR76) 2021; 39
Kim (CR163) 2006; 45
Tao (CR330) 2022; 13
Miller (CR114) 2020; 38
Fu (CR313) 2013; 31
Wang (CR236) 2022; 343
Horvath (CR53) 2009; 131
Sapranauskas (CR54) 2011; 39
Hsu (CR152) 2019; 37
Sabnis (CR304) 2018; 26
Mali (CR58) 2013; 339
Maeder (CR306) 2019; 25
Deltcheva (CR55) 2011; 471
Felgner (CR193) 1987; 84
Bassett, Tibbit, Ponting, Liu (CR62) 2013; 4
Bravo (CR104) 2022; 603
Fan, Cheng, Sun (CR347) 2020; 20
Yang (CR142) 2022; 2022
Zuccaro (CR332) 2020; 183
Komor (CR25) 2016; 533
Shi (CR162) 2017; 24
Horodecka, Düchler (CR346) 2021; 22
Kocak (CR319) 2019; 37
Balboa (CR144) 2015; 5
Jiang (CR205) 2017; 27
Lorenzo-Redondo (CR308) 2016; 530
Nishimura (CR253) 1999; 11
Joung (CR184) 2020; 383
Maeder (CR322) 2013; 10
Zhu (CR318) 2019; 26
Zhou (CR324) 2018; 21
T Wan (1309_CR128) 2022; 8
DM Connor (1309_CR223) 2018; 139
Y Qie (1309_CR338) 2016; 6
GA Newby (1309_CR18) 2021; 595
AV Anzalone (1309_CR27) 2019; 576
M Li (1309_CR243) 2021; 11
PF Robbins (1309_CR248) 2011; 29
YA Nevzorova (1309_CR218) 2012; 56
D Zhao (1309_CR75) 2021; 39
A Aimo (1309_CR303) 2022; 19
Y Fu (1309_CR313) 2013; 31
E Schoger (1309_CR276) 2020; 126
MH Larson (1309_CR147) 2013; 8
H Youn (1309_CR122) 2015; 15
H Nishimasu (1309_CR115) 2018; 361
H Frangoul (1309_CR74) 2021; 384
JR Backstrom (1309_CR186) 2020; 19
A Edraki (1309_CR328) 2019; 73
Y Wu (1309_CR68) 2013; 13
H Yang (1309_CR129) 2020; 21
CL Himeda (1309_CR139) 2021; 20
B Wienert (1309_CR317) 2019; 364
A Seki (1309_CR123) 2018; 215
T Yang (1309_CR258) 2021; 75
R Tachibana (1309_CR119) 2001; 52
S Böhm (1309_CR188) 2020; 6
A Chavez (1309_CR145) 2015; 12
S Majumder (1309_CR241) 2021; 20
R Aliyari (1309_CR45) 2009; 227
YK Jeong (1309_CR155) 2020; 28
C Noack (1309_CR275) 2019; 74
HK Lee (1309_CR161) 2021; 54
BP Kleinstiver (1309_CR342) 2016; 529
T Oka (1309_CR268) 2014; 114
NM Gaudelli (1309_CR26) 2017; 551
Z Li (1309_CR222) 2019; 19
EA Stadtmauer (1309_CR247) 2020; 367
KS Makarova (1309_CR50) 2011; 9
D Tang (1309_CR335) 2021; 8
J Hu (1309_CR240) 2021; 14
H Zhou (1309_CR324) 2018; 21
HA Dad (1309_CR339) 2021; 29
Y Yang (1309_CR40) 2021; 8
H Wang (1309_CR64) 2013; 153
DG Tamay (1309_CR210) 2019; 7
C Anders (1309_CR327) 2014; 513
SK Alsaiari (1309_CR204) 2018; 140
J Wen (1309_CR298) 2022; 30
H Xie (1309_CR106) 2020; 18
Y Sekijima (1309_CR301) 2015; 86
P Horvath (1309_CR44) 2008; 190
M Yüce (1309_CR289) 2021; 172
MF Richter (1309_CR164) 2020; 38
N Matharu (1309_CR284) 2019; 363
J Zhao (1309_CR178) 2020; 16
FJ Mojica (1309_CR39) 2000; 36
A Békési (1309_CR157) 2021; 22
J Fan (1309_CR347) 2020; 20
T Fiolet (1309_CR286) 2022; 28
RJ Platt (1309_CR13) 2014; 159
OO Abudayyeh (1309_CR81) 2017; 550
F Chen (1309_CR32) 2020; 12
K Shi (1309_CR162) 2017; 24
S Zhang (1309_CR312) 2021; 11
L Sousa (1309_CR300) 2021; 97
L Villiger (1309_CR262) 2018; 24
C Liao (1309_CR85) 2021; 55
AH Magadán (1309_CR57) 2012; 7
C Pourcel (1309_CR41) 2005; 151
J Li (1309_CR177) 2020; 48
N Javaid (1309_CR325) 2021; 22
GL Dianov (1309_CR132) 2013; 41
G Maule (1309_CR73) 2021; 182
P Liu (1309_CR120) 2019; 47
MS Liu (1309_CR314) 2020; 11
SJ Amina (1309_CR224) 2020; 15
K Horodecka (1309_CR346) 2021; 22
RL Setten (1309_CR174) 2019; 18
FJ Mojica (1309_CR36) 1995; 17
GK Hansson (1309_CR267) 2011; 12
A Nussenzweig (1309_CR99) 2010; 141
MJ Mitchell (1309_CR200) 2021; 20
SG Conticello (1309_CR153) 2008; 9
AA Dominguez (1309_CR143) 2016; 17
ML Maeder (1309_CR322) 2013; 10
X Zhang (1309_CR238) 2022; 38
B Masepohl (1309_CR38) 1996; 1307
Z Gu (1309_CR274) 2016; 7
F Teng (1309_CR292) 2018; 4
FA Ran (1309_CR22) 2013; 8
V Mekler (1309_CR89) 2017; 114
D Wang (1309_CR264) 2022; 20
T Gaj (1309_CR4) 2013; 31
M Bartneck (1309_CR259) 2021; 173
LS Qi (1309_CR24) 2013; 152
AR Bassett (1309_CR63) 2014; 41
S Ramakrishna (1309_CR126) 2014; 24
SP Li (1309_CR214) 2018; 39
LC Lopes (1309_CR226) 2021; 223
PD Hsu (1309_CR5) 2014; 157
J Liu (1309_CR232) 2021; 337
V Di Maria (1309_CR140) 2020; 13
IB Hilton (1309_CR149) 2015; 33
AD Nahmad (1309_CR320) 2022; 40
S Su (1309_CR83) 2017; 6
BP Kleinstiver (1309_CR112) 2015; 33
Y Xiao (1309_CR97) 2017; 170
E Provasi (1309_CR252) 2012; 18
E Deltcheva (1309_CR55) 2011; 471
MN Hsu (1309_CR152) 2019; 37
A Casini (1309_CR102) 2018; 36
RC Larson (1309_CR254) 2022; 604
AG Rigopoulos (1309_CR299) 2019; 24
ML Leibowitz (1309_CR331) 2021; 53
JD Beane (1309_CR84) 2015; 23
IC Kurt (1309_CR76) 2021; 39
JY Chung (1309_CR285) 2019; 29
X Li (1309_CR278) 2021; 17
DH Haft (1309_CR49) 2005; 1
X Zhao (1309_CR181) 2018; 431
AT Taher (1309_CR293) 2018; 391
AP Rapoport (1309_CR249) 2015; 21
N Luo (1309_CR261) 2021; 28
1309_CR113
XS Liu (1309_CR150) 2016; 167
Y Fan (1309_CR345) 2021; 192
P Mali (1309_CR58) 2013; 339
D Rosenblum (1309_CR199) 2020; 6
X Zhu (1309_CR318) 2019; 26
SC Lin (1309_CR189) 2022; 17
Y Lu (1309_CR82) 2020; 26
SM Klum (1309_CR95) 2018; 37
D Chen (1309_CR217) 2019; 69
D Collias (1309_CR326) 2021; 12
FA Ran (1309_CR131) 2013; 154
GM Bendle (1309_CR251) 2010; 16
AG Harrison (1309_CR287) 2020; 41
D Zhi (1309_CR245) 2020; 325
J Zischewski (1309_CR316) 2017; 35
D Zhao (1309_CR265) 2019; 16
G Gasiunas (1309_CR48) 2012; 109
Y Lee (1309_CR201) 2008; 47
Z Mao (1309_CR134) 2022; 122
AC Komor (1309_CR25) 2016; 533
H Hirano (1309_CR111) 2016; 164
DB Cox (1309_CR6) 2015; 21
TL Roth (1309_CR3) 2021; 16
C Liu (1309_CR202) 2021; 11
WL Chew (1309_CR187) 2016; 13
R Ibraheim (1309_CR329) 2021; 12
N Hoe (1309_CR37) 1999; 5
W Cai (1309_CR33) 2021; 60
A Madsen (1309_CR277) 2020; 142
AV Wright (1309_CR52) 2016; 164
S Chandrasegaran (1309_CR88) 2016; 428
Y Yang (1309_CR142) 2022; 2022
R Rupaimoole (1309_CR239) 2017; 16
MP Zafra (1309_CR158) 2018; 36
Z Ali (1309_CR77) 2018; 23
C Lu (1309_CR169) 2022; 23
BT Luk (1309_CR230) 2015; 220
K Xie (1309_CR67) 2013; 6
B Yang (1309_CR212) 2019; 31
JK Lee (1309_CR101) 2018; 9
M Babuta (1309_CR215) 2019; 70
YT Lin (1309_CR282) 2018; 98
K Chen (1309_CR12) 2019; 70
M Qiu (1309_CR195) 2021; 118
K Zhang (1309_CR209) 2020; 256
C Kunz (1309_CR156) 2009; 66
X Ren (1309_CR60) 2013; 110
L Cong (1309_CR56) 2013; 339
AC Komor (1309_CR160) 2017; 3
SZ Mirjalili Mohanna (1309_CR198) 2022; 350
DC Luther (1309_CR121) 2018; 15
P Wang (1309_CR228) 2018; 57
JA Doudna (1309_CR15) 2014; 346
AV Anzalone (1309_CR172) 2020; 38
A Akinc (1309_CR305) 2019; 14
SH Sternberg (1309_CR93) 2015; 527
K Schumann (1309_CR124) 2015; 112
R Sapranauskas (1309_CR54) 2011; 39
M Bratovič (1309_CR107) 2020; 16
CB Huang (1309_CR225) 2021; 17
G Schwank (1309_CR70) 2013; 13
O Villamizar (1309_CR72) 2019; 27
D Zhang (1309_CR98) 2021; 29
BL Oakes (1309_CR109) 2019; 176
S Stella (1309_CR137) 2017; 24
M Heidenreich (1309_CR19) 2016; 17
C Wilson (1309_CR176) 2020; 38
DM Pegtel (1309_CR213) 2019; 88
R Lorenzo-Redondo (1309_CR308) 2016; 530
VG Sankaran (1309_CR295) 2008; 322
W Derks (1309_CR273) 2020; 126
JS Gootenberg (1309_CR182) 2017; 356
D Lainšček (1309_CR220) 2018; 7
TS Nowicki (1309_CR250) 2019; 25
RO Tadros (1309_CR271) 2019; 74
JD Gillmore (1309_CR31) 2021; 385
B Paul (1309_CR136) 2020; 43
LS Mehta (1309_CR269) 2016; 133
A Bolotin (1309_CR11) 2005; 151
X Li (1309_CR237) 2022; 14
H Deveau (1309_CR43) 2008; 190
I Fonfara (1309_CR138) 2016; 532
D Balboa (1309_CR144) 2015; 5
PL Felgner (1309_CR193) 1987; 84
L Chen (1309_CR348) 2021; 6
D Wang (1309_CR30) 2020; 181
SJ Brouns (1309_CR46) 2008; 321
E Vermersch (1309_CR17) 2020; 116
MV Zuccaro (1309_CR332) 2020; 183
K Zheng (1309_CR168) 2018; 1
AM Brandow (1309_CR294) 2022; 15
SH Safiabadi Tali (1309_CR290) 2021; 34
C Jiang (1309_CR205) 2017; 27
LP Jahromi (1309_CR334) 2021; 8
D Adams (1309_CR302) 2018; 379
LA Gilbert (1309_CR59) 2013; 154
M Pacesa (1309_CR94) 2022; 609
J Yin (1309_CR110) 2022; 13
B Wu (1309_CR229) 2021; 598
S Bhardwaj (1309_CR283) 2022; 40
M Cong (1309_CR340) 2022; 182
TP Huang (1309_CR166) 2019; 37
E Becirovic (1309_CR321) 2022; 79
P V’Kovski (1309_CR79) 2021; 19
DS Thommen (1309_CR246) 2018; 33
S Kondo (1309_CR61) 2013; 195
SH Sternberg (1309_CR90) 2014; 507
Q Cui (1309_CR208) 2018; 41
O Piepenburg (1309_CR183) 2006; 4
A Perrin (1309_CR350) 2017; 6
NTK Nguyen (1309_CR192) 2021; 275
IM Slaymaker (1309_CR343) 2016; 351
S Mulepati (1309_CR96) 2014; 345
J Kim (1309_CR163) 2006; 45
J Joung (1309_CR184) 2020; 383
GF Gerard (1309_CR170) 2002; 30
MD Szczelkun (1309_CR91) 2014; 111
DBT Cox (1309_CR179) 2017; 358
W Jiang (1309_CR66) 2013; 41
YY Zhang (1309_CR263) 2015; 87
ML Maeder (1309_CR306) 2019; 25
M Sedic (1309_CR197) 2018; 55
J Gong (1309_CR257) 2020; 32
1309_CR291
GH Chuai (1309_CR87) 2017; 35
J Peng (1309_CR227) 2021; 9
M Jinek (1309_CR47) 2012; 337
M Wojnilowicz (1309_CR349) 2019; 13
K Nishida (1309_CR167) 2016; 353
HA Rees (1309_CR154) 2018; 19
A Schuster (1309_CR175) 2019; 37
Y Wu (1309_CR20) 2015; 25
JY Wu (1309_CR260) 2018; 8
BP Kleinstiver (1309_CR341) 2015; 523
DR Burton (1309_CR307) 2019; 19
SM Miller (1309_CR114) 2020; 38
S Romeo (1309_CR196) 2009; 119
S Konermann (1309_CR146) 2015; 517
HK Lee (1309_CR165) 2018; 9
T Zhan (1309_CR16) 2019; 55
E Sameiyan (1309_CR203) 2021; 123
F Jiang (1309_CR14) 2017; 46
ME Tanenbaum (1309_CR148) 2014; 159
X Xu (1309_CR336) 2021; 176
X Li (1309_CR244) 2021; 60
B Zetsche (1309_CR133) 2015; 163
C Jiang (1309_CR1) 2020; 97
AR Bassett (1309_CR62) 2013; 4
D Kim (1309_CR80) 2020; 181
X Yao (1309_CR127) 2021; 10
D Singh (1309_CR315) 2018; 25
LY Sung (1309_CR190) 2013; 41
PM Groenen (1309_CR35) 1993; 10
A Noy (1309_CR309) 2019; 134
M Shteinberg (1309_CR71) 2021; 397
M Li (1309_CR141) 2022; 170
R Reshke (1309_CR216) 2020; 4
SY Kwan (1309_CR219) 2020; 71
LW Koblan (1309_CR159) 2018; 36
S Sabnis (1309_CR304) 2018; 26
Y Ishino (1309_CR34) 1987; 169
H Manghwar (1309_CR100) 2020; 7
Z Gao (1309_CR171) 2022; 30
X Yang (1309_CR234) 2019; 141
CF Xu (1309_CR311) 2021; 168
S Stella (1309_CR135) 2017; 546
H Nishimura (1309_CR253) 1999; 11
F Sonntag (1309_CR185) 2010; 107
F Jiang (1309_CR92) 2015; 348
X Li (1309_CR266) 2022; 30
SL Stevens (1309_CR272) 2016; 354
R Barrangou (1309_CR42) 2007; 315
D Witzigmann (1309_CR194) 2020; 159
Q Liu (1309_CR206) 2019; 6
J Tao (1309_CR330) 2022; 13
M Behr (1309_CR29) 2021; 11
EB Esrick (1309_CR297) 2021; 384
SE Gratton (1309_CR337) 2008; 105
T Wang (1309_CR236) 2022; 343
YW Fu (1309_CR21) 2021; 49
A Vojta (1309_CR151) 2016; 44
RT Walton (1309_CR117) 2020; 368
C DeRossi (1309_CR221) 2019; 70
X Li (1309_CR255) 2022; 7
H Qi (1309_CR256) 2022; 11
J Li (1309_CR10) 2021; 14
J Liu (1309_CR235) 2019; 31
F Adikusuma (1309_CR333) 2018; 560
S Shen (1309_CR130) 2017; 50
Y Wu (1309_CR296) 2019; 25
ELA S (1309_CR211) 2013; 12
Y Lin (1309_CR118) 2022; 10
A Pickar-Oliver (1309_CR7) 2019; 20
Z Zuo (1309_CR105) 2022; 5
DD Kocak (1309_CR319) 2019; 37
L Zhao (1309_CR69) 2010; 21
PJ Chen (1309_CR173) 2021; 184
MN Hsu (1309_CR281) 2020; 28
X Zhang (1309_CR280) 2019; 6
Y Zhu (1309_CR270) 2020; 76
H Manghwar (1309_CR2) 2019; 24
Z Zhang (1309_CR207) 2019; 31
H Tang (1309_CR86) 2021; 168
LA Marraffini (1309_CR9) 2010; 463
OO Abudayyeh (1309_CR28) 2016; 353
A East-Seletsky (1309_CR78) 2016; 538
OO Abudayyeh (1309_CR180) 2019; 365
MJ Landrum (1309_CR23) 2016; 44
P Horvath (1309_CR53) 2009; 131
K Tao (1309_CR288) 2021; 22
JH Hu (1309_CR116) 2018; 556
B Bai
References_xml – volume: 7
  year: 2016
  ident: CR274
  article-title: Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13331
– volume: 339
  start-page: 819
  year: 2013
  end-page: 823
  ident: CR56
  article-title: Multiplex genome engineering using CRISPR/Cas systems
  publication-title: Science
  doi: 10.1126/science.1231143
– volume: 131
  start-page: 62
  year: 2009
  end-page: 70
  ident: CR53
  article-title: Comparative analysis of CRISPR loci in lactic acid bacteria genomes
  publication-title: Int. J. Food Microbiol.
  doi: 10.1016/j.ijfoodmicro.2008.05.030
– volume: 5
  start-page: 254
  year: 1999
  end-page: 263
  ident: CR37
  article-title: Rapid molecular genetic subtyping of serotype M1 group A Streptococcus strains
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid0502.990210
– volume: 39
  start-page: 9275
  year: 2011
  end-page: 9282
  ident: CR54
  article-title: The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr606
– volume: 55
  start-page: 106
  year: 2019
  end-page: 119
  ident: CR16
  article-title: CRISPR/Cas9 for cancer research and therapy
  publication-title: Semin. Cancer Biol.
  doi: 10.1016/j.semcancer.2018.04.001
– volume: 25
  start-page: 4373
  year: 2021
  end-page: 4386
  ident: CR279
  article-title: MicroRNA-302c-3p inhibits endothelial cell pyroptosis via directly targeting NOD-, LRR- and pyrin domain-containing protein 3 in atherosclerosis
  publication-title: J. Cell Mol. Med.
  doi: 10.1111/jcmm.16500
– volume: 6
  start-page: 68
  year: 2017
  end-page: 79
  ident: CR350
  article-title: Increased expression of laminin subunit alpha 1 chain by dCas9-VP160
  publication-title: Mol. Ther. Nucleic Acids
  doi: 10.1016/j.omtn.2016.11.004
– volume: 2022
  start-page: 5477024
  year: 2022
  ident: CR142
  article-title: The lncRNA punisher regulates apoptosis and mitochondrial homeostasis of vascular smooth muscle cells via targeting miR-664a-5p and OPA1
  publication-title: Oxid. Med. Cell Longev.
– volume: 18
  start-page: 421
  year: 2019
  end-page: 446
  ident: CR174
  article-title: The current state and future directions of RNAi-based therapeutics
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-019-0017-4
– volume: 141
  start-page: 27
  year: 2010
  end-page: 38
  ident: CR99
  article-title: Origin of chromosomal translocations in lymphoid cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.016
– volume: 23
  start-page: 891
  year: 2018
  end-page: 899
  ident: CR231
  article-title: Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2018.02.001
– volume: 9
  start-page: 467
  year: 2011
  end-page: 477
  ident: CR50
  article-title: Evolution and classification of the CRISPR-Cas systems
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2577
– volume: 35
  start-page: 12
  year: 2017
  end-page: 21
  ident: CR87
  article-title: In silico meets in vivo: towards computational CRISPR-based sgRNA design
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2016.06.008
– volume: 321
  start-page: 960
  year: 2008
  end-page: 964
  ident: CR46
  article-title: Small CRISPR RNAs guide antiviral defense in prokaryotes
  publication-title: Science
  doi: 10.1126/science.1159689
– volume: 159
  start-page: 344
  year: 2020
  end-page: 363
  ident: CR194
  article-title: Lipid nanoparticle technology for therapeutic gene regulation in the liver
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.06.026
– volume: 159
  start-page: 440
  year: 2014
  end-page: 455
  ident: CR13
  article-title: CRISPR-Cas9 knockin mice for genome editing and cancer modeling
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.014
– volume: 603
  start-page: 343
  year: 2022
  end-page: 347
  ident: CR104
  article-title: Structural basis for mismatch surveillance by CRISPR-Cas9
  publication-title: Nature
  doi: 10.1038/s41586-022-04470-1
– volume: 32
  start-page: e2003537
  year: 2020
  ident: CR257
  article-title: A versatile nonviral delivery system for multiplex gene-editing in the liver
  publication-title: Adv. Mater.
  doi: 10.1002/adma.202003537
– volume: 10
  start-page: 977
  year: 2013
  end-page: 979
  ident: CR322
  article-title: CRISPR RNA-guided activation of endogenous human genes
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2598
– volume: 529
  start-page: 490
  year: 2016
  end-page: 495
  ident: CR342
  article-title: High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
  publication-title: Nature
  doi: 10.1038/nature16526
– volume: 52
  start-page: 219
  year: 2001
  end-page: 226
  ident: CR119
  article-title: Quantitative studies on the nuclear transport of plasmid DNA and gene expression employing nonviral vectors
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(01)00211-3
– volume: 97
  start-page: 1111
  year: 2021
  end-page: 1119
  ident: CR300
  article-title: CNS involvement in hereditary transthyretin amyloidosis
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000012965
– volume: 337
  start-page: 224
  year: 2021
  end-page: 235
  ident: CR232
  article-title: Macrophage-biomimetic anti-inflammatory liposomes for homing and treating of aortic dissection
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2021.07.032
– volume: 142
  start-page: 1562
  year: 2020
  end-page: 1578
  ident: CR277
  article-title: An important role for DNMT3A-mediated DNA methylation in cardiomyocyte metabolism and contractility
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.119.044444
– volume: 107
  start-page: 10220
  year: 2010
  end-page: 10225
  ident: CR185
  article-title: A viral assembly factor promotes AAV2 capsid formation in the nucleolus
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1001673107
– volume: 97
  start-page: 73
  year: 2020
  end-page: 88
  ident: CR1
  article-title: Application of CRISPR/Cas9 gene editing technique in the study of cancer treatment
  publication-title: Clin. Genet.
  doi: 10.1111/cge.13589
– volume: 23
  start-page: 1380
  year: 2015
  end-page: 1390
  ident: CR84
  article-title: Clinical scale zinc finger nuclease-mediated gene editing of PD-1 in tumor infiltrating lymphocytes for the treatment of metastatic melanoma
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2015.71
– volume: 9
  year: 2018
  ident: CR165
  article-title: Targeting fidelity of adenine and cytosine base editors in mouse embryos
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07322-7
– volume: 46
  start-page: 505
  year: 2017
  end-page: 529
  ident: CR14
  article-title: CRISPR-Cas9 structures and mechanisms
  publication-title: Annu. Rev. Biophys.
  doi: 10.1146/annurev-biophys-062215-010822
– volume: 507
  start-page: 62
  year: 2014
  end-page: 67
  ident: CR90
  article-title: DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
  publication-title: Nature
  doi: 10.1038/nature13011
– volume: 38
  start-page: 471
  year: 2020
  end-page: 481
  ident: CR114
  article-title: Continuous evolution of SpCas9 variants compatible with non-G PAMs
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0412-8
– volume: 151
  start-page: 2551
  year: 2005
  end-page: 2561
  ident: CR11
  article-title: Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
  publication-title: Microbiology
  doi: 10.1099/mic.0.28048-0
– volume: 367
  start-page: eaba7365
  year: 2020
  ident: CR247
  article-title: CRISPR-engineered T cells in patients with refractory cancer
  publication-title: Science
  doi: 10.1126/science.aba7365
– volume: 12
  start-page: e1609
  year: 2020
  ident: CR32
  article-title: Strategies for nonviral nanoparticle-based delivery of CRISPR/Cas9 therapeutics
  publication-title: Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.
  doi: 10.1002/wnan.1609
– volume: 37
  start-page: 38
  year: 2019
  end-page: 55
  ident: CR175
  article-title: RNAi/CRISPR screens: from a pool to a valid hit
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2018.08.002
– volume: 7
  start-page: 305
  year: 2022
  ident: CR255
  article-title: Lactate metabolism in human health and disease
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-022-01151-3
– volume: 252
  start-page: 120094
  year: 2020
  ident: CR344
  article-title: CRISPR interference-mediated noggin knockdown promotes BMP2-induced osteogenesis and calvarial bone healing
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120094
– volume: 20
  start-page: 1474
  year: 2020
  end-page: 1504
  ident: CR347
  article-title: Functionalized gold nanoparticles: synthesis, properties and biomedical applications
  publication-title: Chem. Rec.
  doi: 10.1002/tcr.202000087
– volume: 12
  start-page: 204
  year: 2011
  end-page: 212
  ident: CR267
  article-title: The immune system in atherosclerosis
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2001
– volume: 220
  start-page: 600
  year: 2015
  end-page: 607
  ident: CR230
  article-title: Cell membrane-camouflaged nanoparticles for drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.07.019
– volume: 24
  start-page: 122
  year: 2014
  end-page: 125
  ident: CR65
  article-title: Generating rats with conditional alleles using CRISPR/Cas9
  publication-title: Cell Res.
  doi: 10.1038/cr.2013.157
– volume: 44
  start-page: 5615
  year: 2016
  end-page: 5628
  ident: CR151
  article-title: Repurposing the CRISPR-Cas9 system for targeted DNA methylation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw159
– volume: 24
  start-page: 521
  year: 2019
  end-page: 533
  ident: CR299
  article-title: Advances in the diagnosis and treatment of transthyretin amyloidosis with cardiac involvement
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-019-09776-3
– volume: 609
  start-page: 191
  year: 2022
  end-page: 196
  ident: CR94
  article-title: R-loop formation and conformational activation mechanisms of Cas9
  publication-title: Nature
  doi: 10.1038/s41586-022-05114-0
– volume: 560
  start-page: E8
  year: 2018
  end-page: e9
  ident: CR333
  article-title: Large deletions induced by Cas9 cleavage
  publication-title: Nature
  doi: 10.1038/s41586-018-0380-z
– volume: 181
  start-page: 914
  year: 2020
  end-page: 921.e910
  ident: CR80
  article-title: The architecture of SARS-CoV-2 transcriptome
  publication-title: Cell
  doi: 10.1016/j.cell.2020.04.011
– volume: 23
  start-page: 9862
  year: 2022
  ident: CR169
  article-title: Prime editing: an all-rounder for genome editing
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms23179862
– volume: 21
  start-page: 914
  year: 2015
  end-page: 921
  ident: CR249
  article-title: NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
  publication-title: Nat. Med.
  doi: 10.1038/nm.3910
– volume: 37
  start-page: 75
  year: 2018
  end-page: 88
  ident: CR95
  article-title: Helix-7 in Argonaute2 shapes the microRNA seed region for rapid target recognition
  publication-title: EMBO J.
  doi: 10.15252/embj.201796474
– volume: 112
  start-page: 10437
  year: 2015
  end-page: 10442
  ident: CR124
  article-title: Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1512503112
– volume: 350
  start-page: 401
  year: 2022
  end-page: 413
  ident: CR198
  article-title: LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.08.042
– volume: 31
  start-page: 397
  year: 2013
  end-page: 405
  ident: CR4
  article-title: ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2013.04.004
– volume: 141
  start-page: 3782
  year: 2019
  end-page: 3786
  ident: CR234
  article-title: Nanoscale ATP-responsive zeolitic imidazole framework-90 as a general platform for cytosolic protein delivery and genome editing
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.8b11996
– volume: 183
  start-page: 1650
  year: 2020
  end-page: 1664.e1615
  ident: CR332
  article-title: Allele-specific chromosome removal after Cas9 cleavage in human embryos
  publication-title: Cell
  doi: 10.1016/j.cell.2020.10.025
– volume: 73
  start-page: 714
  year: 2019
  end-page: 726.e714
  ident: CR328
  article-title: A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing
  publication-title: Mol. Cell.
  doi: 10.1016/j.molcel.2018.12.003
– volume: 41
  start-page: 3483
  year: 2013
  end-page: 3490
  ident: CR132
  article-title: Mammalian base excision repair: the forgotten archangel
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt076
– volume: 523
  start-page: 481
  year: 2015
  end-page: 485
  ident: CR341
  article-title: Engineered CRISPR-Cas9 nucleases with altered PAM specificities
  publication-title: Nature
  doi: 10.1038/nature14592
– volume: 19
  start-page: 770
  year: 2018
  end-page: 788
  ident: CR154
  article-title: Base editing: precision chemistry on the genome and transcriptome of living cells
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-018-0059-1
– volume: 13
  start-page: 868
  year: 2016
  end-page: 874
  ident: CR187
  article-title: A multifunctional AAV-CRISPR-Cas9 and its host response
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3993
– volume: 70
  start-page: 2107
  year: 2019
  end-page: 2122
  ident: CR221
  article-title: Mannose phosphate isomerase and mannose regulate hepatic stellate cell activation and fibrosis in zebrafish and humans
  publication-title: Hepatology
  doi: 10.1002/hep.30677
– volume: 70
  start-page: 667
  year: 2019
  end-page: 697
  ident: CR12
  article-title: CRISPR/Cas genome editing and precision plant breeding in agriculture
  publication-title: Annu. Rev. Plant Biol.
  doi: 10.1146/annurev-arplant-050718-100049
– volume: 6
  year: 2016
  ident: CR338
  article-title: Surface modification of nanoparticles enables selective evasion of phagocytic clearance by distinct macrophage phenotypes
  publication-title: Sci. Rep.
  doi: 10.1038/srep26269
– volume: 576
  start-page: 149
  year: 2019
  end-page: 157
  ident: CR27
  article-title: Search-and-replace genome editing without double-strand breaks or donor DNA
  publication-title: Nature
  doi: 10.1038/s41586-019-1711-4
– volume: 6
  start-page: 1975
  year: 2013
  end-page: 1983
  ident: CR67
  article-title: RNA-guided genome editing in plants using a CRISPR-Cas system
  publication-title: Mol. Plant.
  doi: 10.1093/mp/sst119
– volume: 358
  start-page: 1019
  year: 2017
  end-page: 1027
  ident: CR179
  article-title: RNA editing with CRISPR-Cas13
  publication-title: Science
  doi: 10.1126/science.aaq0180
– volume: 365
  start-page: 382
  year: 2019
  end-page: 386
  ident: CR180
  article-title: A cytosine deaminase for programmable single-base RNA editing
  publication-title: Science
  doi: 10.1126/science.aax7063
– volume: 30
  start-page: 3118
  year: 2022
  end-page: 3132
  ident: CR266
  article-title: Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2022.07.018
– volume: 13
  start-page: 659
  year: 2013
  end-page: 662
  ident: CR68
  article-title: Correction of a genetic disease in mouse via use of CRISPR-Cas9
  publication-title: Cell. Stem Cell.
  doi: 10.1016/j.stem.2013.10.016
– volume: 1
  start-page: e60
  year: 2005
  ident: CR49
  article-title: A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.0010060
– volume: 22
  start-page: 3902
  year: 2021
  ident: CR157
  article-title: Detection of genomic uracil patterns
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22083902
– volume: 337
  start-page: 816
  year: 2012
  end-page: 821
  ident: CR47
  article-title: A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
  publication-title: Science
  doi: 10.1126/science.1225829
– volume: 71
  start-page: 275
  year: 2020
  end-page: 290
  ident: CR219
  article-title: Depletion of TRRAP induces p53-independent senescence in liver cancer by down-regulating mitotic genes
  publication-title: Hepatology
  doi: 10.1002/hep.30807
– volume: 37
  start-page: 820
  year: 2019
  ident: CR166
  article-title: Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0168-1
– volume: 11
  start-page: 2726
  year: 2021
  end-page: 2737
  ident: CR243
  article-title: Integrins as attractive targets for cancer therapeutics
  publication-title: Acta Pharm. Sin. B.
  doi: 10.1016/j.apsb.2021.01.004
– volume: 31
  start-page: 1695
  year: 2013
  end-page: 1706
  ident: CR191
  article-title: Recent progresses in gene delivery-based bone tissue engineering
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2013.08.015
– volume: 353
  start-page: aaf5573
  year: 2016
  ident: CR28
  article-title: C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
  publication-title: Science
  doi: 10.1126/science.aaf5573
– volume: 47
  start-page: 4169
  year: 2019
  end-page: 4180
  ident: CR120
  article-title: Enhanced Cas12a editing in mammalian cells and zebrafish
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz184
– volume: 27
  start-page: 440
  year: 2017
  end-page: 443
  ident: CR205
  article-title: A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and pcsk9 in vivo
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.16
– volume: 60
  start-page: 174
  year: 2005
  end-page: 182
  ident: CR8
  article-title: Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements
  publication-title: J. Mol. Evol.
  doi: 10.1007/s00239-004-0046-3
– volume: 4
  start-page: 220
  year: 2013
  end-page: 228
  ident: CR62
  article-title: Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.06.020
– volume: 126
  start-page: 6
  year: 2020
  end-page: 24
  ident: CR276
  article-title: CRISPR-mediated activation of endogenous gene expression in the postnatal heart
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.314522
– volume: 18
  start-page: e3000747
  year: 2020
  ident: CR106
  article-title: High-fidelity SaCas9 identified by directional screening in human cells
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.3000747
– volume: 151
  start-page: 653
  year: 2005
  end-page: 663
  ident: CR41
  article-title: CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
  publication-title: Microbiology
  doi: 10.1099/mic.0.27437-0
– volume: 24
  start-page: 1012
  year: 2014
  end-page: 1019
  ident: CR125
  article-title: Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
  publication-title: Genome Res.
  doi: 10.1101/gr.171322.113
– volume: 384
  start-page: 205
  year: 2021
  end-page: 215
  ident: CR297
  article-title: Post-transcriptional genetic silencing of BCL11A to treat sickle cell disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2029392
– volume: 43
  start-page: 8
  year: 2020
  end-page: 17
  ident: CR136
  article-title: CRISPR-Cas12a: functional overview and applications
  publication-title: Biomed. J.
  doi: 10.1016/j.bj.2019.10.005
– volume: 363
  start-page: eaau0629
  year: 2019
  ident: CR284
  article-title: CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency
  publication-title: Science
  doi: 10.1126/science.aau0629
– volume: 8
  start-page: rbab033
  year: 2021
  ident: CR335
  article-title: ROS-responsive biomimetic nanoparticles for potential application in targeted anti-atherosclerosis
  publication-title: Regen. Biomater.
  doi: 10.1093/rb/rbab033
– volume: 55
  start-page: 161
  year: 2021
  end-page: 181
  ident: CR85
  article-title: The tracrRNA in CRISPR biology and technologies
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev-genet-071719-022559
– volume: 24
  start-page: 882
  year: 2017
  end-page: 892
  ident: CR137
  article-title: Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3486
– volume: 5
  start-page: 329
  year: 2022
  end-page: 340
  ident: CR105
  article-title: Rational engineering of CRISPR-Cas9 nuclease to attenuate position-dependent off-target effects
  publication-title: CRISPR J.
  doi: 10.1089/crispr.2021.0076
– volume: 15
  start-page: 905
  year: 2018
  end-page: 913
  ident: CR121
  article-title: Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1080/17425247.2018.1517746
– volume: 346
  start-page: 1258096
  year: 2014
  ident: CR15
  article-title: Genome editing. The new frontier of genome engineering with CRISPR-Cas9
  publication-title: Science
  doi: 10.1126/science.1258096
– volume: 76
  start-page: 359
  year: 2019
  end-page: 370
  ident: CR242
  article-title: Mechanisms controlling PD-L1 expression in cancer
  publication-title: Mol. Cell.
  doi: 10.1016/j.molcel.2019.09.030
– volume: 595
  start-page: 295
  year: 2021
  end-page: 302
  ident: CR18
  article-title: Base editing of haematopoietic stem cells rescues sickle cell disease in mice
  publication-title: Nature
  doi: 10.1038/s41586-021-03609-w
– volume: 16
  start-page: 203
  year: 2017
  end-page: 222
  ident: CR239
  article-title: MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.246
– volume: 16
  start-page: 587
  year: 2020
  end-page: 595
  ident: CR107
  article-title: Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-020-0490-4
– volume: 19
  start-page: 155
  year: 2021
  end-page: 170
  ident: CR79
  article-title: Coronavirus biology and replication: implications for SARS-CoV-2
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-020-00468-6
– volume: 50
  start-page: 20
  year: 2017
  end-page: 24
  ident: CR130
  article-title: CRISPR as a strong gene editing tool
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2017.50.1.128
– volume: 190
  start-page: 1390
  year: 2008
  end-page: 1400
  ident: CR43
  article-title: Phage response to CRISPR-encoded resistance in Streptococcus thermophilus
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.01412-07
– volume: 22
  start-page: 757
  year: 2021
  end-page: 773
  ident: CR288
  article-title: The biological and clinical significance of emerging SARS-CoV-2 variants
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-021-00408-x
– volume: 25
  start-page: 776
  year: 2019
  end-page: 783
  ident: CR296
  article-title: Highly efficient therapeutic gene editing of human hematopoietic stem cells
  publication-title: Nat. Med.
  doi: 10.1038/s41591-019-0401-y
– volume: 7
  start-page: 164
  year: 2019
  ident: CR210
  article-title: 3D and 4D printing of polymers for tissue engineering applications
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2019.00164
– volume: 17
  start-page: 5
  year: 2016
  end-page: 15
  ident: CR143
  article-title: Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2015.2
– volume: 13
  year: 2022
  ident: CR110
  article-title: Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-28900-w
– volume: 322
  start-page: 1839
  year: 2008
  end-page: 1842
  ident: CR295
  article-title: Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
  publication-title: Science
  doi: 10.1126/science.1165409
– volume: 60
  start-page: 8596
  year: 2021
  end-page: 8606
  ident: CR33
  article-title: Spatiotemporal delivery of CRISPR/Cas9 genome editing machinery using stimuli-responsive vehicles
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.202005644
– volume: 428
  start-page: 963
  year: 2016
  end-page: 989
  ident: CR88
  article-title: Origins of programmable nucleases for genome engineering
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2015.10.014
– volume: 38
  start-page: 824
  year: 2020
  end-page: 844
  ident: CR172
  article-title: Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0561-9
– volume: 86
  start-page: 1036
  year: 2015
  end-page: 1043
  ident: CR301
  article-title: Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2014-308724
– volume: 169
  start-page: 5429
  year: 1987
  end-page: 5433
  ident: CR34
  article-title: Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product
  publication-title: J. Bacteriol.
  doi: 10.1128/jb.169.12.5429-5433.1987
– volume: 25
  start-page: 2096
  year: 2019
  end-page: 2108
  ident: CR250
  article-title: A pilot trial of the combination of transgenic NY-ESO-1-reactive adoptive cellular therapy with dendritic cell vaccination with or without ipilimumab
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-18-3496
– volume: 163
  start-page: 759
  year: 2015
  end-page: 771
  ident: CR133
  article-title: Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system
  publication-title: Cell
  doi: 10.1016/j.cell.2015.09.038
– volume: 57
  start-page: 1491
  year: 2018
  end-page: 1496
  ident: CR228
  article-title: Thermo-triggered release of CRISPR-Cas9 system by lipid-encapsulated gold nanoparticles for tumor therapy
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.201708689
– volume: 36
  start-page: 265
  year: 2018
  end-page: 271
  ident: CR102
  article-title: A highly specific SpCas9 variant is identified by in vivo screening in yeast
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4066
– volume: 256
  start-page: 120225
  year: 2020
  ident: CR209
  article-title: Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120225
– volume: 8
  start-page: 649896
  year: 2021
  ident: CR40
  article-title: CRISPR/Cas: advances, limitations, and applications for precision cancer research
  publication-title: Front. Med.
  doi: 10.3389/fmed.2021.649896
– volume: 11
  year: 2020
  ident: CR314
  article-title: Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17411-1
– volume: 6
  start-page: eaba5614
  year: 2020
  ident: CR188
  article-title: A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aba5614
– volume: 24
  start-page: 1519
  year: 2018
  end-page: 1525
  ident: CR262
  article-title: Treatment of a metabolic liver disease by in vivo genome base editing in adult mice
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0209-1
– volume: 18
  start-page: 807
  year: 2012
  end-page: 815
  ident: CR252
  article-title: Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
  publication-title: Nat. Med.
  doi: 10.1038/nm.2700
– volume: 192
  start-page: 113642
  year: 2021
  ident: CR345
  article-title: Analytical characterization of liposomes and other lipid nanoparticles for drug delivery
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/j.jpba.2020.113642
– volume: 25
  start-page: 229
  year: 2019
  end-page: 233
  ident: CR306
  article-title: Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0327-9
– volume: 33
  start-page: 510
  year: 2015
  end-page: 517
  ident: CR149
  article-title: Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3199
– volume: 36
  start-page: 843
  year: 2018
  end-page: 846
  ident: CR159
  article-title: Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4172
– volume: 133
  start-page: 916
  year: 2016
  end-page: 947
  ident: CR269
  article-title: Acute myocardial infarction in women: a scientific statement from the American Heart Association
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000351
– volume: 184
  start-page: 5635
  year: 2021
  end-page: 5652.e5629
  ident: CR173
  article-title: Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
  publication-title: Cell
  doi: 10.1016/j.cell.2021.09.018
– volume: 21
  start-page: 361
  year: 2010
  end-page: 369
  ident: CR69
  article-title: A 1-bp deletion in the gammaC-crystallin leads to dominant cataracts in mice
  publication-title: Mamm. Genome
  doi: 10.1007/s00335-010-9275-5
– volume: 40
  start-page: 207
  year: 2022
  end-page: 221
  ident: CR283
  article-title: CRISPR/Cas9 gene editing: new hope for Alzheimer’s disease therapeutics
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2021.07.001
– volume: 20
  start-page: 125
  year: 2021
  end-page: 144
  ident: CR241
  article-title: Targeting Notch in oncology: the path forward
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-00091-3
– volume: 87
  start-page: 1989
  year: 2015
  end-page: 1999
  ident: CR263
  article-title: Rethinking the pathogenesis of hepatitis B virus (HBV) infection
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.24270
– volume: 36
  start-page: 888
  year: 2018
  end-page: 893
  ident: CR158
  article-title: Optimized base editors enable efficient editing in cells, organoids and mice
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4194
– volume: 28
  start-page: 1938
  year: 2020
  end-page: 1952
  ident: CR155
  article-title: Current status and challenges of DNA base editing tools
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2020.07.021
– volume: 14
  start-page: 157
  year: 2021
  ident: CR240
  article-title: Targeting mutant p53 for cancer therapy: direct and indirect strategies
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-021-01169-0
– volume: 26
  start-page: 679
  year: 2019
  end-page: 685
  ident: CR318
  article-title: Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-019-0258-2
– volume: 463
  start-page: 568
  year: 2010
  end-page: 571
  ident: CR9
  article-title: Self versus non-self discrimination during CRISPR RNA-directed immunity
  publication-title: Nature
  doi: 10.1038/nature08703
– volume: 33
  start-page: 547
  year: 2018
  end-page: 562
  ident: CR246
  article-title: T cell dysfunction in cancer
  publication-title: Cancer Cell.
  doi: 10.1016/j.ccell.2018.03.012
– volume: 49
  start-page: 969
  year: 2021
  end-page: 985
  ident: CR21
  article-title: Dynamics and competition of CRISPR-Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1251
– volume: 10
  start-page: 1166
  year: 2022
  end-page: 1192
  ident: CR118
  article-title: Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP
  publication-title: Biomater. Sci.
  doi: 10.1039/D1BM01658J
– volume: 22
  start-page: 6072
  year: 2021
  ident: CR346
  article-title: CRISPR/Cas9: principle, applications, and delivery through extracellular vesicles
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22116072
– volume: 119
  start-page: 70
  year: 2009
  end-page: 79
  ident: CR196
  article-title: Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
  publication-title: J. Clin. Invest.
– volume: 164
  start-page: 29
  year: 2016
  end-page: 44
  ident: CR52
  article-title: Biology and applications of CRISPR systems: harnessing nature’s toolbox for genome engineering
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.035
– volume: 39
  start-page: 542
  year: 2018
  end-page: 551
  ident: CR214
  article-title: Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2017.178
– volume: 7
  start-page: 2715
  year: 2018
  end-page: 2725
  ident: CR220
  article-title: Delivery of an artificial transcription regulator dCas9-VPR by extracellular vesicles for therapeutic gene activation
  publication-title: ACS Synth. Biol.
  doi: 10.1021/acssynbio.8b00192
– volume: 364
  start-page: 286
  year: 2019
  end-page: 289
  ident: CR317
  article-title: Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq
  publication-title: Science
  doi: 10.1126/science.aav9023
– volume: 12
  start-page: 326
  year: 2015
  end-page: 328
  ident: CR145
  article-title: Highly efficient Cas9-mediated transcriptional programming
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3312
– volume: 123
  start-page: 110
  year: 2021
  end-page: 122
  ident: CR203
  article-title: Aptamer-based ATP-responsive delivery systems for cancer diagnosis and treatment
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2020.12.057
– volume: 20
  start-page: 101
  year: 2021
  end-page: 124
  ident: CR200
  article-title: Engineering precision nanoparticles for drug delivery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-0090-8
– volume: 356
  start-page: 438
  year: 2017
  end-page: 442
  ident: CR182
  article-title: Nucleic acid detection with CRISPR-Cas13a/C2c2
  publication-title: Science
  doi: 10.1126/science.aam9321
– volume: 14
  start-page: 2058
  year: 2022
  end-page: 2070
  ident: CR237
  article-title: Multistage-responsive nanocomplexes attenuate ulcerative colitis by improving the accumulation and distribution of oral nucleic acid drugs in the colon
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.1c21595
– volume: 391
  start-page: 155
  year: 2018
  end-page: 167
  ident: CR293
  article-title: Thalassaemia
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31822-6
– volume: 527
  start-page: 110
  year: 2015
  end-page: 113
  ident: CR93
  article-title: Conformational control of DNA target cleavage by CRISPR-Cas9
  publication-title: Nature
  doi: 10.1038/nature15544
– volume: 173
  start-page: 70
  year: 2021
  end-page: 88
  ident: CR259
  article-title: Lipid nanoparticle formulations for targeting leukocytes with therapeutic RNA in liver fibrosis
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2021.03.009
– volume: 275
  start-page: 120965
  year: 2021
  ident: CR192
  article-title: CRISPR activation of long non-coding RNA DANCR promotes bone regeneration
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.120965
– volume: 53
  start-page: 895
  year: 2021
  end-page: 905
  ident: CR331
  article-title: Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-021-00838-7
– volume: 195
  start-page: 715
  year: 2013
  end-page: 721
  ident: CR61
  article-title: Highly improved gene targeting by germline-specific Cas9 expression in Drosophila
  publication-title: Genetics
  doi: 10.1534/genetics.113.156737
– volume: 41
  start-page: 7
  year: 2014
  end-page: 19
  ident: CR63
  article-title: CRISPR/Cas9 and genome editing in Drosophila
  publication-title: J. Genet. Genomics.
  doi: 10.1016/j.jgg.2013.12.004
– volume: 546
  start-page: 559
  year: 2017
  end-page: 563
  ident: CR135
  article-title: Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
  publication-title: Nature
  doi: 10.1038/nature22398
– volume: 54
  start-page: 98
  year: 2021
  end-page: 105
  ident: CR161
  article-title: Development of CRISPR technology for precise single-base genome editing: a brief review
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2021.54.2.217
– volume: 19
  start-page: 19
  year: 2019
  end-page: 28
  ident: CR222
  article-title: In vitro and in vivo RNA inhibition by CD9-HuR functionalized exosomes encapsulated with miRNA or CRISPR/dCas9
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.8b02689
– volume: 353
  start-page: aaf8729
  year: 2016
  ident: CR167
  article-title: Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems
  publication-title: Science
  doi: 10.1126/science.aaf8729
– volume: 30
  start-page: 3118
  year: 2002
  end-page: 3129
  ident: CR170
  article-title: The role of template-primer in protection of reverse transcriptase from thermal inactivation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkf417
– volume: 17
  start-page: 1004
  year: 2022
  end-page: 1027
  ident: CR189
  article-title: Generation of CRISPR-Cas9-mediated genetic knockout human intestinal tissue-derived enteroid lines by lentivirus transduction and single-cell cloning
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-021-00669-0
– volume: 8
  start-page: 2002499
  year: 2021
  ident: CR334
  article-title: Chemically engineered immune cell-derived microrobots and biomimetic nanoparticles: emerging biodiagnostic and therapeutic tools
  publication-title: Adv. Sci.
  doi: 10.1002/advs.202002499
– volume: 29
  start-page: 13
  year: 2021
  end-page: 31
  ident: CR339
  article-title: Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2020.11.030
– volume: 17
  start-page: 85
  year: 1995
  end-page: 93
  ident: CR36
  article-title: Long stretches of short tandem repeats are present in the largest replicons of the Archaea Haloferax mediterranei and Haloferax volcanii and could be involved in replicon partitioning
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1995.mmi_17010085.x
– volume: 351
  start-page: 84
  year: 2016
  end-page: 88
  ident: CR343
  article-title: Rationally engineered Cas9 nucleases with improved specificity
  publication-title: Science
  doi: 10.1126/science.aad5227
– volume: 21
  start-page: 121
  year: 2015
  end-page: 131
  ident: CR6
  article-title: Therapeutic genome editing: prospects and challenges
  publication-title: Nat. Med.
  doi: 10.1038/nm.3793
– volume: 315
  start-page: 1709
  year: 2007
  end-page: 1712
  ident: CR42
  article-title: CRISPR provides acquired resistance against viruses in prokaryotes
  publication-title: Science
  doi: 10.1126/science.1138140
– volume: 168
  start-page: 55
  year: 2021
  end-page: 78
  ident: CR86
  article-title: Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.03.001
– volume: 40
  start-page: 1807
  year: 2022
  end-page: 1813
  ident: CR320
  article-title: Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-022-01377-0
– volume: 24
  start-page: 131
  year: 2017
  end-page: 139
  ident: CR162
  article-title: Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3344
– volume: 29
  start-page: 917
  year: 2011
  end-page: 924
  ident: CR248
  article-title: Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2010.32.2537
– volume: 168
  start-page: 3
  year: 2021
  end-page: 29
  ident: CR311
  article-title: Rational designs of in vivo CRISPR-Cas delivery systems
  publication-title: Adv. Drug. Deliv. Rev.
  doi: 10.1016/j.addr.2019.11.005
– volume: 70
  start-page: 2123
  year: 2019
  end-page: 2141
  ident: CR215
  article-title: Dysregulated autophagy and lysosome function are linked to exosome production by micro-RNA 155 in alcoholic liver disease
  publication-title: Hepatology
  doi: 10.1002/hep.30766
– volume: 28
  start-page: 441
  year: 2020
  end-page: 451
  ident: CR281
  article-title: Coactivation of endogenous Wnt10b and Foxc2 by CRISPR activation enhances BMSC osteogenesis and promotes calvarial bone regeneration
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2019.11.029
– volume: 176
  start-page: 113891
  year: 2021
  ident: CR336
  article-title: Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2021.113891
– volume: 538
  start-page: 270
  year: 2016
  end-page: 273
  ident: CR78
  article-title: Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
  publication-title: Nature
  doi: 10.1038/nature19802
– volume: 471
  start-page: 602
  year: 2011
  end-page: 607
  ident: CR55
  article-title: CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
  publication-title: Nature
  doi: 10.1038/nature09886
– volume: 60
  start-page: 21200
  year: 2021
  end-page: 21204
  ident: CR244
  article-title: Hypoxia-responsive gene editing to reduce tumor thermal tolerance for mild-photothermal therapy
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.202107036
– volume: 18
  start-page: 32
  year: 2020
  end-page: 44
  ident: CR323
  article-title: CRISPR/dCas9 platforms in plants: strategies and applications beyond genome editing
  publication-title: Plant Biotechnol. J.
  doi: 10.1111/pbi.13232
– volume: 152
  start-page: 1173
  year: 2013
  end-page: 1183
  ident: CR24
  article-title: Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
  publication-title: Cell
  doi: 10.1016/j.cell.2013.02.022
– volume: 38
  start-page: 883
  year: 2020
  end-page: 891
  ident: CR164
  article-title: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0453-z
– volume: 325
  start-page: 52
  year: 2020
  end-page: 71
  ident: CR245
  article-title: Photothermal therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2020.06.032
– volume: 6
  start-page: 1900386
  year: 2019
  ident: CR280
  article-title: CRISPR/Cas9 delivery mediated with hydroxyl-rich nanosystems for gene editing in aorta
  publication-title: Adv. Sci.
  doi: 10.1002/advs.201900386
– volume: 182
  start-page: 114108
  year: 2022
  ident: CR340
  article-title: Technology insight: plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers?
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2021.114108
– volume: 397
  start-page: 2195
  year: 2021
  end-page: 2211
  ident: CR71
  article-title: Cystic fibrosis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)32542-3
– volume: 154
  start-page: 1380
  year: 2013
  end-page: 1389
  ident: CR131
  article-title: Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.021
– volume: 139
  start-page: 163
  year: 2018
  end-page: 184
  ident: CR223
  article-title: Gold nanoparticles for the delivery of cancer therapeutics
  publication-title: Adv. Cancer Res.
  doi: 10.1016/bs.acr.2018.05.001
– volume: 27
  start-page: 1737
  year: 2019
  end-page: 1748
  ident: CR72
  article-title: Targeted activation of cystic fibrosis transmembrane conductance regulator
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2019.07.002
– volume: 114
  start-page: 565
  year: 2014
  end-page: 571
  ident: CR268
  article-title: Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.114.300507
– volume: 6
  start-page: eabc9450
  year: 2020
  ident: CR199
  article-title: CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc9450
– volume: 11
  start-page: 141
  year: 1999
  end-page: 151
  ident: CR253
  article-title: Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80089-8
– volume: 76
  start-page: 1703
  year: 2020
  end-page: 1713
  ident: CR270
  article-title: Type A aortic dissection-experience over 5 decades: JACC historical breakthroughs in perspective
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2020.07.061
– volume: 38
  start-page: 110196
  year: 2022
  ident: CR238
  article-title: Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.110196
– volume: 30
  start-page: 2942
  year: 2022
  end-page: 2951
  ident: CR171
  article-title: A truncated reverse transcriptase enhances prime editing by split AAV vectors
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2022.07.001
– volume: 343
  start-page: 765
  year: 2022
  end-page: 776
  ident: CR236
  article-title: MMP-responsive transformation nanomaterials with IAP antagonist to boost immune checkpoint therapy
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.02.018
– volume: 604
  start-page: 563
  year: 2022
  end-page: 570
  ident: CR254
  article-title: CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
  publication-title: Nature
  doi: 10.1038/s41586-022-04585-5
– volume: 31
  start-page: 822
  year: 2013
  end-page: 826
  ident: CR313
  article-title: High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2623
– volume: 24
  start-page: 1020
  year: 2014
  end-page: 1027
  ident: CR126
  article-title: Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
  publication-title: Genome Res.
  doi: 10.1101/gr.171264.113
– volume: 8
  start-page: eabp9435
  year: 2022
  ident: CR128
  article-title: Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abp9435
– volume: 12
  start-page: 347
  year: 2013
  end-page: 357
  ident: CR211
  article-title: Extracellular vesicles: biology and emerging therapeutic opportunities
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3978
– volume: 7
  start-page: e40913
  year: 2012
  ident: CR57
  article-title: Cleavage of phage DNA by the Streptococcus thermophilus CRISPR3-Cas system
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0040913
– volume: 550
  start-page: 407
  year: 2017
  end-page: 410
  ident: CR103
  article-title: Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
  publication-title: Nature
  doi: 10.1038/nature24268
– volume: 21
  start-page: 6461
  year: 2020
  ident: CR129
  article-title: Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21186461
– volume: 35
  start-page: 95
  year: 2017
  end-page: 104
  ident: CR316
  article-title: Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2016.12.003
– volume: 10
  start-page: 1057
  year: 1993
  end-page: 1065
  ident: CR35
  article-title: Nature of DNA polymorphism in the direct repeat cluster of Mycobacterium tuberculosis; application for strain differentiation by a novel typing method
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1993.tb00976.x
– volume: 37
  start-page: 107447
  year: 2019
  ident: CR152
  article-title: CRISPR technologies for stem cell engineering and regenerative medicine
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2019.107447
– volume: 379
  start-page: 11
  year: 2018
  end-page: 21
  ident: CR302
  article-title: Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1716153
– volume: 11
  start-page: 9833
  year: 2021
  end-page: 9846
  ident: CR202
  article-title: A programmable hierarchical-responsive nanoCRISPR elicits robust activation of endogenous target to treat cancer
  publication-title: Theranostics
  doi: 10.7150/thno.62449
– ident: CR291
– volume: 109
  start-page: E2579
  year: 2012
  end-page: 2586
  ident: CR48
  article-title: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1208507109
– volume: 69
  start-page: 2164
  year: 2019
  end-page: 2179
  ident: CR217
  article-title: p53 up-regulated modulator of apoptosis induction mediates acetaminophen-induced necrosis and liver injury in mice
  publication-title: Hepatology
  doi: 10.1002/hep.30422
– volume: 354
  start-page: i4098
  year: 2016
  ident: CR272
  article-title: Blood pressure variability and cardiovascular disease: systematic review and meta-analysis
  publication-title: BMJ
  doi: 10.1136/bmj.i4098
– volume: 56
  start-page: 1140
  year: 2012
  end-page: 1149
  ident: CR218
  article-title: Cyclin E1 controls proliferation of hepatic stellate cells and is essential for liver fibrogenesis in mice
  publication-title: Hepatology
  doi: 10.1002/hep.25736
– volume: 14
  start-page: 352
  year: 2021
  end-page: 360
  ident: CR10
  article-title: Genome editing mediated by SpCas9 variants with broad non-canonical PAM compatibility in plants
  publication-title: Mol. Plant.
  doi: 10.1016/j.molp.2020.12.017
– volume: 9
  year: 2018
  ident: CR101
  article-title: Directed evolution of CRISPR-Cas9 to increase its specificity
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05477-x
– volume: 66
  start-page: 1021
  year: 2009
  end-page: 1038
  ident: CR156
  article-title: DNA Repair in mammalian cells: mismatched repair: variations on a theme
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-009-8739-9
– volume: 361
  start-page: 1259
  year: 2018
  end-page: 1262
  ident: CR115
  article-title: Engineered CRISPR-Cas9 nuclease with expanded targeting space
  publication-title: Science
  doi: 10.1126/science.aas9129
– volume: 368
  start-page: 290
  year: 2020
  end-page: 296
  ident: CR117
  article-title: Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
  publication-title: Science
  doi: 10.1126/science.aba8853
– volume: 11
  start-page: 614
  year: 2021
  end-page: 648
  ident: CR312
  article-title: Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
  publication-title: Theranostics
  doi: 10.7150/thno.47007
– volume: 8
  year: 2018
  ident: CR260
  article-title: Exosome-Mimetic Nanovesicles from Hepatocytes promote hepatocyte proliferation in vitro and liver regeneration in vivo
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20505-y
– volume: 181
  start-page: 136
  year: 2020
  end-page: 150
  ident: CR30
  article-title: CRISPR-based therapeutic genome editing: strategies and in vivo delivery by AAV vectors
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.023
– volume: 6
  start-page: 225
  year: 2021
  ident: CR348
  article-title: Recent progress in targeted delivery vectors based on biomimetic nanoparticles
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-021-00631-2
– volume: 31
  start-page: e1905751
  year: 2019
  ident: CR207
  article-title: Dual-locking nanoparticles disrupt the PD-1/PD-L1 pathway for efficient cancer immunotherapy
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201905751
– volume: 25
  start-page: 347
  year: 2018
  end-page: 354
  ident: CR315
  article-title: Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-018-0051-7
– volume: 16
  start-page: e1907301
  year: 2020
  ident: CR178
  article-title: Photoactivatable RNA N(6) -Methyladenosine Editing with CRISPR-Cas13
  publication-title: Small
  doi: 10.1002/smll.201907301
– volume: 172
  start-page: 112752
  year: 2021
  ident: CR289
  article-title: COVID-19 diagnosis—a review of current methods
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2020.112752
– volume: 110
  start-page: 19012
  year: 2013
  end-page: 19017
  ident: CR60
  article-title: Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1318481110
– volume: 88
  start-page: 487
  year: 2019
  end-page: 514
  ident: CR213
  article-title: Exosomes
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev-biochem-013118-111902
– volume: 339
  start-page: 823
  year: 2013
  end-page: 826
  ident: CR58
  article-title: RNA-guided human genome engineering via Cas9
  publication-title: Science
  doi: 10.1126/science.1232033
– volume: 10
  start-page: e12076
  year: 2021
  ident: CR127
  article-title: Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing
  publication-title: J. Extracell. Vesicles.
  doi: 10.1002/jev2.12076
– volume: 13
  start-page: 187
  year: 2019
  end-page: 202
  ident: CR349
  article-title: Super-resolution imaging of proton sponge-triggered rupture of endosomes and cytosolic release of small interfering RNA
  publication-title: ACS Nano.
  doi: 10.1021/acsnano.8b05151
– volume: 26
  start-page: 732
  year: 2020
  end-page: 740
  ident: CR82
  article-title: Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-0840-5
– volume: 29
  start-page: 1442
  year: 2019
  end-page: 1452
  ident: CR285
  article-title: Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance
  publication-title: Genome Res.
  doi: 10.1101/gr.246900.118
– volume: 159
  start-page: 635
  year: 2014
  end-page: 646
  ident: CR148
  article-title: A protein-tagging system for signal amplification in gene expression and fluorescence imaging
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.039
– volume: 383
  start-page: 1492
  year: 2020
  end-page: 1494
  ident: CR184
  article-title: Detection of SARS-CoV-2 with SHERLOCK one-pot testing
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2026172
– volume: 170
  start-page: 48
  year: 2017
  end-page: 60.e11
  ident: CR97
  article-title: Structure basis for directional r-loop formation and substrate handover mechanisms in type I CRISPR-Cas system
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.012
– volume: 12
  year: 2021
  ident: CR326
  article-title: CRISPR technologies and the search for the PAM-free nuclease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-20633-y
– volume: 170
  start-page: 100
  year: 2022
  end-page: 114
  ident: CR141
  article-title: miR-564: a potential regulator of vascular smooth muscle cells and therapeutic target for aortic dissection
  publication-title: J. Mol. Cell Cardiol.
  doi: 10.1016/j.yjmcc.2022.06.003
– volume: 11
  year: 2020
  ident: CR310
  article-title: CRISPR based editing of SIV proviral DNA in ART treated non-human primates
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19821-7
– volume: 190
  start-page: 1401
  year: 2008
  end-page: 1412
  ident: CR44
  article-title: Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.01415-07
– volume: 23
  start-page: 374
  year: 2018
  end-page: 378
  ident: CR77
  article-title: CRISPR/Cas13 as a tool for RNA interference
  publication-title: Trends Plant Sci.
  doi: 10.1016/j.tplants.2018.03.003
– volume: 30
  start-page: 164
  year: 2022
  end-page: 174
  ident: CR298
  article-title: Single AAV-mediated CRISPR-Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2021.05.010
– volume: 215
  start-page: 985
  year: 2018
  end-page: 997
  ident: CR123
  article-title: Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20171626
– volume: 41
  start-page: 1
  year: 2018
  end-page: 25
  ident: CR208
  article-title: Modulating ROS to overcome multidrug resistance in cancer
  publication-title: Drug Resist. Updat.
  doi: 10.1016/j.drup.2018.11.001
– volume: 28
  start-page: 202
  year: 2022
  end-page: 221
  ident: CR286
  article-title: Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review
  publication-title: Clin. Microbiol. Infect.
  doi: 10.1016/j.cmi.2021.10.005
– volume: 154
  start-page: 442
  year: 2013
  end-page: 451
  ident: CR59
  article-title: CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.044
– volume: 9
  start-page: 6528
  year: 2021
  end-page: 6541
  ident: CR227
  article-title: Delivery of miR-320a-3p by gold nanoparticles combined with photothermal therapy for directly targeting Sp1 in lung cancer
  publication-title: Biomater. Sci.
  doi: 10.1039/D1BM01124C
– volume: 31
  start-page: e1802896
  year: 2019
  ident: CR212
  article-title: Exosome biochemistry and advanced nanotechnology for next-generation theranostic platforms
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201802896
– volume: 598
  start-page: 120405
  year: 2021
  ident: CR229
  article-title: Cell penetrating peptide TAT-functionalized liposomes for efficient ophthalmic delivery of flurbiprofen: penetration and its underlying mechanism, retention, anti-inflammation and biocompatibility
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2021.120405
– volume: 385
  start-page: 493
  year: 2021
  end-page: 502
  ident: CR31
  article-title: CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2107454
– volume: 15
  start-page: 20
  year: 2022
  ident: CR294
  article-title: Advances in the diagnosis and treatment of sickle cell disease
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-022-01237-z
– volume: 134
  start-page: 1385
  year: 2019
  end-page: 1394
  ident: CR309
  article-title: Optimizing treatment of HIV-associated lymphoma
  publication-title: Blood
  doi: 10.1182/blood-2018-01-791400
– volume: 20
  start-page: 298
  year: 2021
  end-page: 311
  ident: CR139
  article-title: Targeted epigenetic repression by CRISPR/dSaCas9 suppresses pathogenic DUX4-fl expression in FSHD
  publication-title: Mol. Ther. Methods Clin. Dev.
  doi: 10.1016/j.omtm.2020.12.001
– volume: 16
  start-page: 145
  year: 2021
  end-page: 166
  ident: CR3
  article-title: Genetic disease and therapy
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathmechdis-012419-032626
– volume: 513
  start-page: 569
  year: 2014
  end-page: 573
  ident: CR327
  article-title: Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
  publication-title: Nature
  doi: 10.1038/nature13579
– volume: 12
  year: 2021
  ident: CR329
  article-title: Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26518-y
– volume: 20
  start-page: 490
  year: 2019
  end-page: 507
  ident: CR7
  article-title: The next generation of CRISPR-Cas technologies and applications
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-019-0131-5
– volume: 8
  start-page: 2180
  year: 2013
  end-page: 2196
  ident: CR147
  article-title: CRISPR interference (CRISPRi) for sequence-specific control of gene expression
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.132
– volume: 4
  start-page: 63
  year: 2018
  ident: CR292
  article-title: Repurposing CRISPR-Cas12b for mammalian genome engineering
  publication-title: Cell Discov.
  doi: 10.1038/s41421-018-0069-3
– volume: 345
  start-page: 1479
  year: 2014
  end-page: 1484
  ident: CR96
  article-title: Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target
  publication-title: Science
  doi: 10.1126/science.1256996
– volume: 13
  start-page: 653
  year: 2013
  end-page: 658
  ident: CR70
  article-title: Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
  publication-title: Cell. Stem Cell.
  doi: 10.1016/j.stem.2013.11.002
– volume: 157
  start-page: 1262
  year: 2014
  end-page: 1278
  ident: CR5
  article-title: Development and applications of CRISPR-Cas9 for genome engineering
  publication-title: Cell
  doi: 10.1016/j.cell.2014.05.010
– volume: 48
  start-page: 5684
  year: 2020
  end-page: 5694
  ident: CR177
  article-title: Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa269
– volume: 530
  start-page: 51
  year: 2016
  end-page: 56
  ident: CR308
  article-title: Persistent HIV-1 replication maintains the tissue reservoir during therapy
  publication-title: Nature
  doi: 10.1038/nature16933
– volume: 19
  start-page: 139
  year: 2020
  end-page: 148
  ident: CR186
  article-title: Optimization of S. aureus dCas9 and CRISPRi elements for a single adeno-associated virus that targets an endogenous gene
  publication-title: Mol. Ther. Methods Clin. Dev.
  doi: 10.1016/j.omtm.2020.09.001
– volume: 17
  start-page: e2007593
  year: 2021
  ident: CR225
  article-title: Highly sensitive strain sensors based on molecules-gold nanoparticles networks for high-resolution human pulse analysis
  publication-title: Small
  doi: 10.1002/smll.202007593
– volume: 5
  start-page: 448
  year: 2015
  end-page: 459
  ident: CR144
  article-title: Conditionally stabilized dCas9 activator for controlling gene expression in human cell reprogramming and differentiation
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2015.08.001
– volume: 45
  start-page: 6407
  year: 2006
  end-page: 6416
  ident: CR163
  article-title: Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase
  publication-title: Biochemistry
  doi: 10.1021/bi0522394
– volume: 39
  start-page: 41
  year: 2021
  end-page: 46
  ident: CR76
  article-title: CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0609-x
– volume: 116
  start-page: 894
  year: 2020
  end-page: 907
  ident: CR17
  article-title: CRISPR/Cas9 gene-editing strategies in cardiovascular cells
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvz250
– volume: 47
  start-page: 5163
  year: 2008
  end-page: 5166
  ident: CR201
  article-title: Charge-conversion ternary polyplex with endosome disruption moiety: a technique for efficient and safe gene delivery
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.200800963
– volume: 348
  start-page: 1477
  year: 2015
  end-page: 1481
  ident: CR92
  article-title: STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition
  publication-title: Science
  doi: 10.1126/science.aab1452
– volume: 41
  start-page: e139
  year: 2013
  ident: CR190
  article-title: Enhanced and prolonged baculovirus-mediated expression by incorporating recombinase system and in cis elements: a comparative study
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt442
– volume: 16
  start-page: 203
  year: 2019
  end-page: 212
  ident: CR265
  article-title: Epidemiology of cardiovascular disease in China: current features and implications
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-018-0119-4
– volume: 7
  start-page: 1902312
  year: 2020
  ident: CR100
  article-title: CRISPR/Cas systems in genome editing: methodologies and tools for sgRNA design, off-target evaluation, and strategies to mitigate off-target effects
  publication-title: Adv. Sci.
  doi: 10.1002/advs.201902312
– volume: 122
  start-page: 211
  year: 2022
  end-page: 222
  ident: CR134
  article-title: CRISPR/Cas12a-based technology: a powerful tool for biosensing in food safety
  publication-title: Trends Food Sci. Technol.
  doi: 10.1016/j.tifs.2022.02.030
– volume: 79
  start-page: 130
  year: 2022
  ident: CR321
  article-title: Maybe you can turn me on: CRISPRa-based strategies for therapeutic applications
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-022-04175-8
– volume: 31
  start-page: e1902575
  year: 2019
  ident: CR235
  article-title: Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201902575
– volume: 517
  start-page: 583
  year: 2015
  end-page: 588
  ident: CR146
  article-title: Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
  publication-title: Nature
  doi: 10.1038/nature14136
– volume: 22
  start-page: 397
  year: 2021
  ident: CR325
  article-title: Functional comparison between VP64-dCas9-VP64 and dCas9-VP192 CRISPR activators in human embryonic kidney cells
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22010397
– volume: 533
  start-page: 420
  year: 2016
  end-page: 424
  ident: CR25
  article-title: Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
  publication-title: Nature
  doi: 10.1038/nature17946
– volume: 11
  start-page: 2150
  year: 2021
  end-page: 2171
  ident: CR29
  article-title: In vivo delivery of CRISPR-Cas9 therapeutics: progress and challenges
  publication-title: Acta Pharm. Sin. B.
  doi: 10.1016/j.apsb.2021.05.020
– volume: 28
  start-page: 10
  year: 2021
  end-page: 18
  ident: CR261
  article-title: Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery
  publication-title: Drug Deliv.
  doi: 10.1080/10717544.2020.1850917
– volume: 13
  year: 2022
  ident: CR330
  article-title: Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31322-3
– volume: 4
  start-page: e204
  year: 2006
  ident: CR183
  article-title: DNA detection using recombination proteins
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.0040204
– volume: 140
  start-page: 143
  year: 2018
  end-page: 146
  ident: CR204
  article-title: Endosomal escape and delivery of CRISPR/Cas9 genome editing machinery enabled by nanoscale zeolitic imidazolate framework
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.7b11754
– volume: 111
  start-page: 9798
  year: 2014
  end-page: 9803
  ident: CR91
  article-title: Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1402597111
– volume: 15
  start-page: 9823
  year: 2020
  end-page: 9857
  ident: CR224
  article-title: A review on the synthesis and functionalization of gold nanoparticles as a drug delivery vehicle
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S279094
– volume: 14
  start-page: 1084
  year: 2019
  end-page: 1087
  ident: CR305
  article-title: The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/s41565-019-0591-y
– volume: 13
  start-page: 168
  year: 2020
  ident: CR140
  article-title: Development and validation of CRISPR activator systems for overexpression of CB1 receptors in neurons
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2020.00168
– volume: 384
  start-page: 252
  year: 2021
  end-page: 260
  ident: CR74
  article-title: CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2031054
– volume: 6
  start-page: e1249558
  year: 2017
  ident: CR83
  article-title: CRISPR-Cas9-mediated disruption of PD-1 on human T cells for adoptive cellular therapies of EBV positive gastric cancer
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2016.1249558
– volume: 75
  start-page: 1420
  year: 2021
  end-page: 1433
  ident: CR258
  article-title: Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2021.08.011
– volume: 4
  start-page: 52
  year: 2020
  end-page: 68
  ident: CR216
  article-title: Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0502-4
– volume: 182
  start-page: 185
  year: 2021
  end-page: 224
  ident: CR73
  article-title: Rewriting CFTR to cure cystic fibrosis
  publication-title: Prog. Mol. Biol. Transl. Sci.
  doi: 10.1016/bs.pmbts.2020.12.018
– volume: 556
  start-page: 57
  year: 2018
  end-page: 63
  ident: CR116
  article-title: Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
  publication-title: Nature
  doi: 10.1038/nature26155
– volume: 15
  start-page: 1337
  year: 2015
  end-page: 1348
  ident: CR122
  article-title: Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy
  publication-title: Expert Opin. Biol. Ther.
  doi: 10.1517/14712598.2015.1057563
– volume: 41
  start-page: e188
  year: 2013
  ident: CR66
  article-title: Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt780
– volume: 3
  start-page: eaao4774
  year: 2017
  ident: CR160
  article-title: Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aao4774
– volume: 105
  start-page: 11613
  year: 2008
  end-page: 11618
  ident: CR337
  article-title: The effect of particle design on cellular internalization pathways
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0801763105
– volume: 21
  start-page: 440
  year: 2018
  end-page: 446
  ident: CR324
  article-title: In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR-dCas9-activator transgenic mice
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-017-0060-6
– volume: 227
  start-page: 176
  year: 2009
  end-page: 188
  ident: CR45
  article-title: RNA-based viral immunity initiated by the Dicer family of host immune receptors
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2008.00722.x
– volume: 19
  start-page: 655
  year: 2022
  end-page: 667
  ident: CR303
  article-title: RNA-targeting and gene editing therapies for transthyretin amyloidosis
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-022-00683-z
– volume: 532
  start-page: 517
  year: 2016
  end-page: 521
  ident: CR138
  article-title: The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
  publication-title: Nature
  doi: 10.1038/nature17945
– volume: 24
  start-page: 1102
  year: 2019
  end-page: 1125
  ident: CR2
  article-title: CRISPR/Cas system: recent advances and future prospects for genome editing
  publication-title: Trends Plant Sci.
  doi: 10.1016/j.tplants.2019.09.006
– volume: 1
  start-page: 32
  year: 2018
  ident: CR168
  article-title: Highly efficient base editing in bacteria using a Cas9-cytidine deaminase fusion
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-018-0035-5
– volume: 17
  start-page: 3413
  year: 2021
  end-page: 3427
  ident: CR278
  article-title: Targeting non-coding RNAs in unstable atherosclerotic plaques: mechanism, regulation, possibilities, and limitations
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.62506
– volume: 26
  start-page: 1509
  year: 2018
  end-page: 1519
  ident: CR304
  article-title: A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human primates
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2018.03.010
– volume: 38
  start-page: 1431
  year: 2020
  end-page: 1440
  ident: CR176
  article-title: Programmable m(6)A modification of cellular RNAs with a Cas13-directed methyltransferase
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0572-6
– volume: 223
  start-page: 121634
  year: 2021
  ident: CR226
  article-title: Gold nanoparticles capped with polysaccharides extracted from pineapple gum: Evaluation of their hemocompatibility and electrochemical sensing properties
  publication-title: Talanta
  doi: 10.1016/j.talanta.2020.121634
– volume: 55
  start-page: 341
  year: 2018
  end-page: 354
  ident: CR197
  article-title: Safety evaluation of lipid nanoparticle-formulated modified mRNA in the Sprague-Dawley rat and cynomolgus monkey
  publication-title: Vet. Pathol.
  doi: 10.1177/0300985817738095
– volume: 34
  start-page: e00228
  year: 2021
  end-page: 20
  ident: CR290
  article-title: Tools and techniques for severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 detection
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00228-20
– volume: 8
  start-page: 2281
  year: 2013
  end-page: 2308
  ident: CR22
  article-title: Genome engineering using the CRISPR-Cas9 system
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.143
– ident: CR113
– volume: 153
  start-page: 910
  year: 2013
  end-page: 918
  ident: CR64
  article-title: One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.025
– volume: 84
  start-page: 7413
  year: 1987
  end-page: 7417
  ident: CR193
  article-title: Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.84.21.7413
– volume: 44
  start-page: D862
  year: 2016
  end-page: 868
  ident: CR23
  article-title: ClinVar: public archive of interpretations of clinically relevant variants
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1222
– volume: 29
  start-page: 207
  year: 2021
  end-page: 221
  ident: CR98
  article-title: CRISPR/Cas: a powerful tool for gene function study and crop improvement
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2020.10.003
– volume: 116
  start-page: 20969
  year: 2019
  end-page: 20976
  ident: CR108
  article-title: Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1906843116
– volume: 16
  start-page: 565
  year: 2010
  end-page: 570
  ident: CR251
  article-title: Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
  publication-title: Nat. Med.
  doi: 10.1038/nm.2128
– volume: 164
  start-page: 950
  year: 2016
  end-page: 961
  ident: CR111
  article-title: Structure and engineering of Francisella novicida Cas9
  publication-title: Cell
  doi: 10.1016/j.cell.2016.01.039
– volume: 37
  start-page: 657
  year: 2019
  end-page: 666
  ident: CR319
  article-title: Increasing the specificity of CRISPR systems with engineered RNA secondary structures
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0095-1
– volume: 17
  start-page: 36
  year: 2016
  end-page: 44
  ident: CR19
  article-title: Applications of CRISPR-Cas systems in neuroscience
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2015.2
– volume: 156
  start-page: 935
  year: 2014
  end-page: 949
  ident: CR51
  article-title: Crystal structure of Cas9 in complex with guide RNA and target DNA
  publication-title: Cell
  doi: 10.1016/j.cell.2014.02.001
– volume: 39
  start-page: 35
  year: 2021
  end-page: 40
  ident: CR75
  article-title: Glycosylase base editors enable C-to-A and C-to-G base changes
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0592-2
– volume: 551
  start-page: 464
  year: 2017
  end-page: 471
  ident: CR26
  article-title: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
  publication-title: Nature
  doi: 10.1038/nature24644
– volume: 33
  start-page: 1293
  year: 2015
  end-page: 1298
  ident: CR112
  article-title: Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3404
– volume: 118
  start-page: e2020401118
  year: 2021
  ident: CR195
  article-title: Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2020401118
– volume: 7
  start-page: eabj0624
  year: 2021
  ident: CR233
  article-title: Genome-editing prodrug: targeted delivery and conditional stabilization of CRISPR-Cas9 for precision therapy of inflammatory disease
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abj0624
– volume: 167
  start-page: 233
  year: 2016
  end-page: 247.e217
  ident: CR150
  article-title: Editing DNA methylation in the mammalian genome
  publication-title: Cell
  doi: 10.1016/j.cell.2016.08.056
– volume: 74
  start-page: 1804
  year: 2019
  end-page: 1819
  ident: CR275
  article-title: KLF15-Wnt-dependent cardiac reprogramming up-regulates SHISA3 in the mammalian heart
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2019.07.076
– volume: 41
  start-page: 1100
  year: 2020
  end-page: 1115
  ident: CR287
  article-title: Mechanisms of SARS-CoV-2 transmission and pathogenesis
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2020.10.004
– volume: 98
  start-page: 1141
  year: 2018
  end-page: 1154.e1147
  ident: CR282
  article-title: APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.05.008
– volume: 19
  start-page: 77
  year: 2019
  end-page: 78
  ident: CR307
  article-title: Advancing an HIV vaccine; advancing vaccinology
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0103-6
– volume: 550
  start-page: 280
  year: 2017
  end-page: 284
  ident: CR81
  article-title: RNA targeting with CRISPR-Cas13
  publication-title: Nature
  doi: 10.1038/nature24049
– volume: 431
  start-page: 171
  year: 2018
  end-page: 181
  ident: CR181
  article-title: A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2018.05.042
– volume: 1307
  start-page: 26
  year: 1996
  end-page: 30
  ident: CR38
  article-title: Long tandemly repeated repetitive (LTRR) sequences in the filamentous cyanobacterium Anabaena sp. PCC 7120
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/0167-4781(96)00040-1
– volume: 11
  start-page: 1511
  year: 2022
  end-page: 1524
  ident: CR256
  article-title: Glucose-responsive nanogels efficiently maintain the stability and activity of therapeutic enzymes
  publication-title: Nanotechnol. Rev.
  doi: 10.1515/ntrev-2022-0095
– volume: 74
  start-page: 1494
  year: 2019
  end-page: 1504
  ident: CR271
  article-title: Optimal treatment of uncomplicated type B aortic dissection: JACC review topic of the week
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2019.07.063
– volume: 6
  start-page: 1801423
  year: 2019
  ident: CR206
  article-title: Multistage delivery nanoparticle facilitates efficient CRISPR/dCas9 activation and tumor growth suppression in vivo
  publication-title: Adv. Sci.
  doi: 10.1002/advs.201801423
– volume: 126
  start-page: 552
  year: 2020
  end-page: 565
  ident: CR273
  article-title: Polyploidy in cardiomyocytes: roadblock to heart regeneration?
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315408
– volume: 114
  start-page: 5443
  year: 2017
  end-page: 5448
  ident: CR89
  article-title: Mechanism of duplex DNA destabilization by RNA-guided Cas9 nuclease during target interrogation
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1619926114
– volume: 9
  year: 2008
  ident: CR153
  article-title: The AID/APOBEC family of nucleic acid mutators
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-6-229
– volume: 36
  start-page: 244
  year: 2000
  end-page: 246
  ident: CR39
  article-title: Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2000.01838.x
– volume: 176
  start-page: 254
  year: 2019
  end-page: 267.e216
  ident: CR109
  article-title: CRISPR-Cas9 circular permutants as programmable scaffolds for genome modification
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.052
– volume: 25
  start-page: 67
  year: 2015
  end-page: 79
  ident: CR20
  article-title: Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells
  publication-title: Cell Res.
  doi: 10.1038/cr.2014.160
– volume: 20
  year: 2022
  ident: CR264
  article-title: CRISPR/Cas9 delivery by NIR-responsive biomimetic nanoparticles for targeted HBV therapy
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-01233-4
– volume: 195
  start-page: 715
  year: 2013
  ident: 1309_CR61
  publication-title: Genetics
  doi: 10.1534/genetics.113.156737
– volume: 7
  start-page: 164
  year: 2019
  ident: 1309_CR210
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2019.00164
– volume: 13
  start-page: 653
  year: 2013
  ident: 1309_CR70
  publication-title: Cell. Stem Cell.
  doi: 10.1016/j.stem.2013.11.002
– volume: 24
  start-page: 1012
  year: 2014
  ident: 1309_CR125
  publication-title: Genome Res.
  doi: 10.1101/gr.171322.113
– volume: 75
  start-page: 1420
  year: 2021
  ident: 1309_CR258
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2021.08.011
– volume: 118
  start-page: e2020401118
  year: 2021
  ident: 1309_CR195
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.2020401118
– volume: 13
  year: 2022
  ident: 1309_CR330
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-31322-3
– volume: 17
  start-page: 1004
  year: 2022
  ident: 1309_CR189
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-021-00669-0
– volume: 256
  start-page: 120225
  year: 2020
  ident: 1309_CR209
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120225
– volume: 1307
  start-page: 26
  year: 1996
  ident: 1309_CR38
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/0167-4781(96)00040-1
– volume: 183
  start-page: 1650
  year: 2020
  ident: 1309_CR332
  publication-title: Cell
  doi: 10.1016/j.cell.2020.10.025
– volume: 176
  start-page: 113891
  year: 2021
  ident: 1309_CR336
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2021.113891
– volume: 60
  start-page: 174
  year: 2005
  ident: 1309_CR8
  publication-title: J. Mol. Evol.
  doi: 10.1007/s00239-004-0046-3
– ident: 1309_CR291
  doi: 10.3390/cells10081931
– volume: 73
  start-page: 714
  year: 2019
  ident: 1309_CR328
  publication-title: Mol. Cell.
  doi: 10.1016/j.molcel.2018.12.003
– volume: 55
  start-page: 341
  year: 2018
  ident: 1309_CR197
  publication-title: Vet. Pathol.
  doi: 10.1177/0300985817738095
– volume: 31
  start-page: e1902575
  year: 2019
  ident: 1309_CR235
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201902575
– volume: 7
  year: 2016
  ident: 1309_CR274
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13331
– volume: 38
  start-page: 1431
  year: 2020
  ident: 1309_CR176
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0572-6
– volume: 20
  start-page: 1474
  year: 2020
  ident: 1309_CR347
  publication-title: Chem. Rec.
  doi: 10.1002/tcr.202000087
– volume: 365
  start-page: 382
  year: 2019
  ident: 1309_CR180
  publication-title: Science
  doi: 10.1126/science.aax7063
– volume: 43
  start-page: 8
  year: 2020
  ident: 1309_CR136
  publication-title: Biomed. J.
  doi: 10.1016/j.bj.2019.10.005
– volume: 159
  start-page: 635
  year: 2014
  ident: 1309_CR148
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.039
– volume: 44
  start-page: D862
  year: 2016
  ident: 1309_CR23
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1222
– volume: 322
  start-page: 1839
  year: 2008
  ident: 1309_CR295
  publication-title: Science
  doi: 10.1126/science.1165409
– volume: 22
  start-page: 6072
  year: 2021
  ident: 1309_CR346
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22116072
– volume: 116
  start-page: 894
  year: 2020
  ident: 1309_CR17
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvz250
– volume: 164
  start-page: 29
  year: 2016
  ident: 1309_CR52
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.035
– volume: 36
  start-page: 888
  year: 2018
  ident: 1309_CR158
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4194
– volume: 70
  start-page: 2107
  year: 2019
  ident: 1309_CR221
  publication-title: Hepatology
  doi: 10.1002/hep.30677
– volume: 38
  start-page: 471
  year: 2020
  ident: 1309_CR114
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0412-8
– volume: 60
  start-page: 21200
  year: 2021
  ident: 1309_CR244
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.202107036
– volume: 25
  start-page: 2096
  year: 2019
  ident: 1309_CR250
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-18-3496
– volume: 463
  start-page: 568
  year: 2010
  ident: 1309_CR9
  publication-title: Nature
  doi: 10.1038/nature08703
– volume: 112
  start-page: 10437
  year: 2015
  ident: 1309_CR124
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1512503112
– volume: 55
  start-page: 106
  year: 2019
  ident: 1309_CR16
  publication-title: Semin. Cancer Biol.
  doi: 10.1016/j.semcancer.2018.04.001
– volume: 16
  start-page: 203
  year: 2019
  ident: 1309_CR265
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-018-0119-4
– volume: 7
  start-page: 1902312
  year: 2020
  ident: 1309_CR100
  publication-title: Adv. Sci.
  doi: 10.1002/advs.201902312
– volume: 37
  start-page: 107447
  year: 2019
  ident: 1309_CR152
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2019.107447
– volume: 36
  start-page: 843
  year: 2018
  ident: 1309_CR159
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4172
– volume: 123
  start-page: 110
  year: 2021
  ident: 1309_CR203
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2020.12.057
– volume: 397
  start-page: 2195
  year: 2021
  ident: 1309_CR71
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)32542-3
– volume: 26
  start-page: 679
  year: 2019
  ident: 1309_CR318
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-019-0258-2
– volume: 345
  start-page: 1479
  year: 2014
  ident: 1309_CR96
  publication-title: Science
  doi: 10.1126/science.1256996
– volume: 69
  start-page: 2164
  year: 2019
  ident: 1309_CR217
  publication-title: Hepatology
  doi: 10.1002/hep.30422
– volume: 595
  start-page: 295
  year: 2021
  ident: 1309_CR18
  publication-title: Nature
  doi: 10.1038/s41586-021-03609-w
– volume: 603
  start-page: 343
  year: 2022
  ident: 1309_CR104
  publication-title: Nature
  doi: 10.1038/s41586-022-04470-1
– volume: 14
  start-page: 352
  year: 2021
  ident: 1309_CR10
  publication-title: Mol. Plant.
  doi: 10.1016/j.molp.2020.12.017
– volume: 220
  start-page: 600
  year: 2015
  ident: 1309_CR230
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2015.07.019
– volume: 36
  start-page: 265
  year: 2018
  ident: 1309_CR102
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4066
– volume: 23
  start-page: 1380
  year: 2015
  ident: 1309_CR84
  publication-title: Mol. Ther.
  doi: 10.1038/mt.2015.71
– volume: 215
  start-page: 985
  year: 2018
  ident: 1309_CR123
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20171626
– volume: 6
  start-page: 1900386
  year: 2019
  ident: 1309_CR280
  publication-title: Adv. Sci.
  doi: 10.1002/advs.201900386
– volume: 8
  start-page: 2002499
  year: 2021
  ident: 1309_CR334
  publication-title: Adv. Sci.
  doi: 10.1002/advs.202002499
– volume: 41
  start-page: e188
  year: 2013
  ident: 1309_CR66
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt780
– volume: 5
  start-page: 448
  year: 2015
  ident: 1309_CR144
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2015.08.001
– volume: 546
  start-page: 559
  year: 2017
  ident: 1309_CR135
  publication-title: Nature
  doi: 10.1038/nature22398
– volume: 30
  start-page: 164
  year: 2022
  ident: 1309_CR298
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2021.05.010
– volume: 13
  start-page: 168
  year: 2020
  ident: 1309_CR140
  publication-title: Front. Mol. Neurosci.
  doi: 10.3389/fnmol.2020.00168
– volume: 41
  start-page: 1
  year: 2018
  ident: 1309_CR208
  publication-title: Drug Resist. Updat.
  doi: 10.1016/j.drup.2018.11.001
– volume: 227
  start-page: 176
  year: 2009
  ident: 1309_CR45
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2008.00722.x
– volume: 339
  start-page: 823
  year: 2013
  ident: 1309_CR58
  publication-title: Science
  doi: 10.1126/science.1232033
– volume: 6
  start-page: eaba5614
  year: 2020
  ident: 1309_CR188
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aba5614
– volume: 164
  start-page: 950
  year: 2016
  ident: 1309_CR111
  publication-title: Cell
  doi: 10.1016/j.cell.2016.01.039
– volume: 12
  year: 2021
  ident: 1309_CR326
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-20633-y
– volume: 24
  start-page: 1102
  year: 2019
  ident: 1309_CR2
  publication-title: Trends Plant Sci.
  doi: 10.1016/j.tplants.2019.09.006
– volume: 13
  start-page: 868
  year: 2016
  ident: 1309_CR187
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3993
– volume: 8
  start-page: 2281
  year: 2013
  ident: 1309_CR22
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.143
– volume: 14
  start-page: 157
  year: 2021
  ident: 1309_CR240
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-021-01169-0
– volume: 337
  start-page: 816
  year: 2012
  ident: 1309_CR47
  publication-title: Science
  doi: 10.1126/science.1225829
– volume: 18
  start-page: 807
  year: 2012
  ident: 1309_CR252
  publication-title: Nat. Med.
  doi: 10.1038/nm.2700
– volume: 169
  start-page: 5429
  year: 1987
  ident: 1309_CR34
  publication-title: J. Bacteriol.
  doi: 10.1128/jb.169.12.5429-5433.1987
– volume: 105
  start-page: 11613
  year: 2008
  ident: 1309_CR337
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0801763105
– volume: 26
  start-page: 732
  year: 2020
  ident: 1309_CR82
  publication-title: Nat. Med.
  doi: 10.1038/s41591-020-0840-5
– volume: 2022
  start-page: 5477024
  year: 2022
  ident: 1309_CR142
  publication-title: Oxid. Med. Cell Longev.
– volume: 60
  start-page: 8596
  year: 2021
  ident: 1309_CR33
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.202005644
– volume: 170
  start-page: 48
  year: 2017
  ident: 1309_CR97
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.012
– volume: 11
  start-page: 2150
  year: 2021
  ident: 1309_CR29
  publication-title: Acta Pharm. Sin. B.
  doi: 10.1016/j.apsb.2021.05.020
– volume: 368
  start-page: 290
  year: 2020
  ident: 1309_CR117
  publication-title: Science
  doi: 10.1126/science.aba8853
– volume: 28
  start-page: 441
  year: 2020
  ident: 1309_CR281
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2019.11.029
– volume: 6
  start-page: 68
  year: 2017
  ident: 1309_CR350
  publication-title: Mol. Ther. Nucleic Acids
  doi: 10.1016/j.omtn.2016.11.004
– volume: 315
  start-page: 1709
  year: 2007
  ident: 1309_CR42
  publication-title: Science
  doi: 10.1126/science.1138140
– volume: 348
  start-page: 1477
  year: 2015
  ident: 1309_CR92
  publication-title: Science
  doi: 10.1126/science.aab1452
– volume: 12
  start-page: 326
  year: 2015
  ident: 1309_CR145
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3312
– volume: 29
  start-page: 917
  year: 2011
  ident: 1309_CR248
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2010.32.2537
– volume: 530
  start-page: 51
  year: 2016
  ident: 1309_CR308
  publication-title: Nature
  doi: 10.1038/nature16933
– volume: 33
  start-page: 547
  year: 2018
  ident: 1309_CR246
  publication-title: Cancer Cell.
  doi: 10.1016/j.ccell.2018.03.012
– volume: 18
  start-page: e3000747
  year: 2020
  ident: 1309_CR106
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.3000747
– volume: 44
  start-page: 5615
  year: 2016
  ident: 1309_CR151
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkw159
– volume: 21
  start-page: 361
  year: 2010
  ident: 1309_CR69
  publication-title: Mamm. Genome
  doi: 10.1007/s00335-010-9275-5
– volume: 275
  start-page: 120965
  year: 2021
  ident: 1309_CR192
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.120965
– volume: 168
  start-page: 3
  year: 2021
  ident: 1309_CR311
  publication-title: Adv. Drug. Deliv. Rev.
  doi: 10.1016/j.addr.2019.11.005
– volume: 21
  start-page: 121
  year: 2015
  ident: 1309_CR6
  publication-title: Nat. Med.
  doi: 10.1038/nm.3793
– volume: 40
  start-page: 207
  year: 2022
  ident: 1309_CR283
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2021.07.001
– volume: 18
  start-page: 421
  year: 2019
  ident: 1309_CR174
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-019-0017-4
– volume: 29
  start-page: 1442
  year: 2019
  ident: 1309_CR285
  publication-title: Genome Res.
  doi: 10.1101/gr.246900.118
– volume: 154
  start-page: 1380
  year: 2013
  ident: 1309_CR131
  publication-title: Cell
  doi: 10.1016/j.cell.2013.08.021
– volume: 31
  start-page: 1695
  year: 2013
  ident: 1309_CR191
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2013.08.015
– volume: 159
  start-page: 344
  year: 2020
  ident: 1309_CR194
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.06.026
– volume: 19
  start-page: 155
  year: 2021
  ident: 1309_CR79
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/s41579-020-00468-6
– volume: 11
  start-page: 1511
  year: 2022
  ident: 1309_CR256
  publication-title: Nanotechnol. Rev.
  doi: 10.1515/ntrev-2022-0095
– volume: 25
  start-page: 4373
  year: 2021
  ident: 1309_CR279
  publication-title: J. Cell Mol. Med.
  doi: 10.1111/jcmm.16500
– volume: 532
  start-page: 517
  year: 2016
  ident: 1309_CR138
  publication-title: Nature
  doi: 10.1038/nature17945
– volume: 84
  start-page: 7413
  year: 1987
  ident: 1309_CR193
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.84.21.7413
– volume: 87
  start-page: 1989
  year: 2015
  ident: 1309_CR263
  publication-title: J. Med. Virol.
  doi: 10.1002/jmv.24270
– volume: 391
  start-page: 155
  year: 2018
  ident: 1309_CR293
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)31822-6
– volume: 24
  start-page: 882
  year: 2017
  ident: 1309_CR137
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3486
– volume: 533
  start-page: 420
  year: 2016
  ident: 1309_CR25
  publication-title: Nature
  doi: 10.1038/nature17946
– volume: 39
  start-page: 41
  year: 2021
  ident: 1309_CR76
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0609-x
– volume: 10
  start-page: e12076
  year: 2021
  ident: 1309_CR127
  publication-title: J. Extracell. Vesicles.
  doi: 10.1002/jev2.12076
– volume: 19
  start-page: 770
  year: 2018
  ident: 1309_CR154
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-018-0059-1
– volume: 70
  start-page: 667
  year: 2019
  ident: 1309_CR12
  publication-title: Annu. Rev. Plant Biol.
  doi: 10.1146/annurev-arplant-050718-100049
– volume: 13
  start-page: 659
  year: 2013
  ident: 1309_CR68
  publication-title: Cell. Stem Cell.
  doi: 10.1016/j.stem.2013.10.016
– volume: 22
  start-page: 397
  year: 2021
  ident: 1309_CR325
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22010397
– volume: 88
  start-page: 487
  year: 2019
  ident: 1309_CR213
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev-biochem-013118-111902
– volume: 384
  start-page: 205
  year: 2021
  ident: 1309_CR297
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2029392
– volume: 116
  start-page: 20969
  year: 2019
  ident: 1309_CR108
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1906843116
– volume: 20
  start-page: 490
  year: 2019
  ident: 1309_CR7
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-019-0131-5
– volume: 538
  start-page: 270
  year: 2016
  ident: 1309_CR78
  publication-title: Nature
  doi: 10.1038/nature19802
– volume: 50
  start-page: 20
  year: 2017
  ident: 1309_CR130
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2017.50.1.128
– volume: 517
  start-page: 583
  year: 2015
  ident: 1309_CR146
  publication-title: Nature
  doi: 10.1038/nature14136
– volume: 11
  year: 2020
  ident: 1309_CR314
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-17411-1
– volume: 560
  start-page: E8
  year: 2018
  ident: 1309_CR333
  publication-title: Nature
  doi: 10.1038/s41586-018-0380-z
– volume: 10
  start-page: 1057
  year: 1993
  ident: 1309_CR35
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1993.tb00976.x
– volume: 23
  start-page: 374
  year: 2018
  ident: 1309_CR77
  publication-title: Trends Plant Sci.
  doi: 10.1016/j.tplants.2018.03.003
– volume: 353
  start-page: aaf8729
  year: 2016
  ident: 1309_CR167
  publication-title: Science
  doi: 10.1126/science.aaf8729
– volume: 36
  start-page: 244
  year: 2000
  ident: 1309_CR39
  publication-title: Mol. Microbiol.
  doi: 10.1046/j.1365-2958.2000.01838.x
– volume: 41
  start-page: 3483
  year: 2013
  ident: 1309_CR132
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt076
– volume: 122
  start-page: 211
  year: 2022
  ident: 1309_CR134
  publication-title: Trends Food Sci. Technol.
  doi: 10.1016/j.tifs.2022.02.030
– volume: 173
  start-page: 70
  year: 2021
  ident: 1309_CR259
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2021.03.009
– volume: 46
  start-page: 505
  year: 2017
  ident: 1309_CR14
  publication-title: Annu. Rev. Biophys.
  doi: 10.1146/annurev-biophys-062215-010822
– volume: 11
  start-page: 2726
  year: 2021
  ident: 1309_CR243
  publication-title: Acta Pharm. Sin. B.
  doi: 10.1016/j.apsb.2021.01.004
– volume: 39
  start-page: 542
  year: 2018
  ident: 1309_CR214
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2017.178
– volume: 8
  start-page: 2180
  year: 2013
  ident: 1309_CR147
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2013.132
– volume: 6
  year: 2016
  ident: 1309_CR338
  publication-title: Sci. Rep.
  doi: 10.1038/srep26269
– volume: 41
  start-page: e139
  year: 2013
  ident: 1309_CR190
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt442
– volume: 140
  start-page: 143
  year: 2018
  ident: 1309_CR204
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.7b11754
– volume: 4
  start-page: 63
  year: 2018
  ident: 1309_CR292
  publication-title: Cell Discov.
  doi: 10.1038/s41421-018-0069-3
– volume: 56
  start-page: 1140
  year: 2012
  ident: 1309_CR218
  publication-title: Hepatology
  doi: 10.1002/hep.25736
– volume: 556
  start-page: 57
  year: 2018
  ident: 1309_CR116
  publication-title: Nature
  doi: 10.1038/nature26155
– volume: 5
  start-page: 329
  year: 2022
  ident: 1309_CR105
  publication-title: CRISPR J.
  doi: 10.1089/crispr.2021.0076
– volume: 9
  start-page: 6528
  year: 2021
  ident: 1309_CR227
  publication-title: Biomater. Sci.
  doi: 10.1039/D1BM01124C
– volume: 25
  start-page: 67
  year: 2015
  ident: 1309_CR20
  publication-title: Cell Res.
  doi: 10.1038/cr.2014.160
– volume: 1
  start-page: 32
  year: 2018
  ident: 1309_CR168
  publication-title: Commun. Biol.
  doi: 10.1038/s42003-018-0035-5
– volume: 513
  start-page: 569
  year: 2014
  ident: 1309_CR327
  publication-title: Nature
  doi: 10.1038/nature13579
– volume: 8
  year: 2018
  ident: 1309_CR260
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-20505-y
– volume: 346
  start-page: 1258096
  year: 2014
  ident: 1309_CR15
  publication-title: Science
  doi: 10.1126/science.1258096
– volume: 52
  start-page: 219
  year: 2001
  ident: 1309_CR119
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(01)00211-3
– volume: 8
  start-page: 649896
  year: 2021
  ident: 1309_CR40
  publication-title: Front. Med.
  doi: 10.3389/fmed.2021.649896
– volume: 33
  start-page: 510
  year: 2015
  ident: 1309_CR149
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3199
– volume: 550
  start-page: 280
  year: 2017
  ident: 1309_CR81
  publication-title: Nature
  doi: 10.1038/nature24049
– volume: 6
  start-page: eabc9450
  year: 2020
  ident: 1309_CR199
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abc9450
– volume: 16
  start-page: 565
  year: 2010
  ident: 1309_CR251
  publication-title: Nat. Med.
  doi: 10.1038/nm.2128
– volume: 11
  start-page: 141
  year: 1999
  ident: 1309_CR253
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80089-8
– volume: 9
  start-page: 467
  year: 2011
  ident: 1309_CR50
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2577
– volume: 28
  start-page: 1938
  year: 2020
  ident: 1309_CR155
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2020.07.021
– volume: 142
  start-page: 1562
  year: 2020
  ident: 1309_CR277
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.119.044444
– volume: 14
  start-page: 1084
  year: 2019
  ident: 1309_CR305
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/s41565-019-0591-y
– volume: 79
  start-page: 130
  year: 2022
  ident: 1309_CR321
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-022-04175-8
– volume: 176
  start-page: 254
  year: 2019
  ident: 1309_CR109
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.052
– volume: 23
  start-page: 891
  year: 2018
  ident: 1309_CR231
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2018.02.001
– volume: 6
  start-page: 1801423
  year: 2019
  ident: 1309_CR206
  publication-title: Adv. Sci.
  doi: 10.1002/advs.201801423
– volume: 25
  start-page: 347
  year: 2018
  ident: 1309_CR315
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/s41594-018-0051-7
– volume: 30
  start-page: 3118
  year: 2022
  ident: 1309_CR266
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2022.07.018
– volume: 74
  start-page: 1804
  year: 2019
  ident: 1309_CR275
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2019.07.076
– volume: 22
  start-page: 3902
  year: 2021
  ident: 1309_CR157
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms22083902
– volume: 19
  start-page: 655
  year: 2022
  ident: 1309_CR303
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-022-00683-z
– volume: 8
  start-page: eabp9435
  year: 2022
  ident: 1309_CR128
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abp9435
– volume: 97
  start-page: 73
  year: 2020
  ident: 1309_CR1
  publication-title: Clin. Genet.
  doi: 10.1111/cge.13589
– volume: 6
  start-page: e1249558
  year: 2017
  ident: 1309_CR83
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2016.1249558
– volume: 3
  start-page: eaao4774
  year: 2017
  ident: 1309_CR160
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aao4774
– volume: 24
  start-page: 131
  year: 2017
  ident: 1309_CR162
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3344
– volume: 190
  start-page: 1401
  year: 2008
  ident: 1309_CR44
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.01415-07
– volume: 428
  start-page: 963
  year: 2016
  ident: 1309_CR88
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2015.10.014
– volume: 10
  start-page: 1166
  year: 2022
  ident: 1309_CR118
  publication-title: Biomater. Sci.
  doi: 10.1039/D1BM01658J
– volume: 24
  start-page: 1020
  year: 2014
  ident: 1309_CR126
  publication-title: Genome Res.
  doi: 10.1101/gr.171264.113
– volume: 367
  start-page: eaba7365
  year: 2020
  ident: 1309_CR247
  publication-title: Science
  doi: 10.1126/science.aba7365
– volume: 11
  year: 2020
  ident: 1309_CR310
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19821-7
– volume: 30
  start-page: 3118
  year: 2002
  ident: 1309_CR170
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkf417
– volume: 38
  start-page: 110196
  year: 2022
  ident: 1309_CR238
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.110196
– volume: 12
  start-page: e1609
  year: 2020
  ident: 1309_CR32
  publication-title: Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.
  doi: 10.1002/wnan.1609
– volume: 19
  start-page: 77
  year: 2019
  ident: 1309_CR307
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0103-6
– volume: 54
  start-page: 98
  year: 2021
  ident: 1309_CR161
  publication-title: BMB Rep.
  doi: 10.5483/BMBRep.2021.54.2.217
– volume: 126
  start-page: 6
  year: 2020
  ident: 1309_CR276
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.118.314522
– volume: 26
  start-page: 1509
  year: 2018
  ident: 1309_CR304
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2018.03.010
– volume: 6
  start-page: 225
  year: 2021
  ident: 1309_CR348
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-021-00631-2
– volume: 5
  start-page: 254
  year: 1999
  ident: 1309_CR37
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid0502.990210
– volume: 32
  start-page: e2003537
  year: 2020
  ident: 1309_CR257
  publication-title: Adv. Mater.
  doi: 10.1002/adma.202003537
– volume: 71
  start-page: 275
  year: 2020
  ident: 1309_CR219
  publication-title: Hepatology
  doi: 10.1002/hep.30807
– volume: 223
  start-page: 121634
  year: 2021
  ident: 1309_CR226
  publication-title: Talanta
  doi: 10.1016/j.talanta.2020.121634
– volume: 39
  start-page: 9275
  year: 2011
  ident: 1309_CR54
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr606
– volume: 159
  start-page: 440
  year: 2014
  ident: 1309_CR13
  publication-title: Cell
  doi: 10.1016/j.cell.2014.09.014
– volume: 35
  start-page: 12
  year: 2017
  ident: 1309_CR87
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2016.06.008
– volume: 379
  start-page: 11
  year: 2018
  ident: 1309_CR302
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1716153
– volume: 151
  start-page: 653
  year: 2005
  ident: 1309_CR41
  publication-title: Microbiology
  doi: 10.1099/mic.0.27437-0
– volume: 181
  start-page: 914
  year: 2020
  ident: 1309_CR80
  publication-title: Cell
  doi: 10.1016/j.cell.2020.04.011
– volume: 141
  start-page: 3782
  year: 2019
  ident: 1309_CR234
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.8b11996
– volume: 343
  start-page: 765
  year: 2022
  ident: 1309_CR236
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.02.018
– volume: 354
  start-page: i4098
  year: 2016
  ident: 1309_CR272
  publication-title: BMJ
  doi: 10.1136/bmj.i4098
– volume: 9
  year: 2018
  ident: 1309_CR165
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07322-7
– volume: 15
  start-page: 9823
  year: 2020
  ident: 1309_CR224
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S279094
– volume: 384
  start-page: 252
  year: 2021
  ident: 1309_CR74
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2031054
– volume: 6
  start-page: 1975
  year: 2013
  ident: 1309_CR67
  publication-title: Mol. Plant.
  doi: 10.1093/mp/sst119
– volume: 126
  start-page: 552
  year: 2020
  ident: 1309_CR273
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315408
– volume: 152
  start-page: 1173
  year: 2013
  ident: 1309_CR24
  publication-title: Cell
  doi: 10.1016/j.cell.2013.02.022
– volume: 18
  start-page: 32
  year: 2020
  ident: 1309_CR323
  publication-title: Plant Biotechnol. J.
  doi: 10.1111/pbi.13232
– volume: 576
  start-page: 149
  year: 2019
  ident: 1309_CR27
  publication-title: Nature
  doi: 10.1038/s41586-019-1711-4
– volume: 507
  start-page: 62
  year: 2014
  ident: 1309_CR90
  publication-title: Nature
  doi: 10.1038/nature13011
– volume: 98
  start-page: 1141
  year: 2018
  ident: 1309_CR282
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.05.008
– volume: 97
  start-page: 1111
  year: 2021
  ident: 1309_CR300
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000012965
– volume: 15
  start-page: 1337
  year: 2015
  ident: 1309_CR122
  publication-title: Expert Opin. Biol. Ther.
  doi: 10.1517/14712598.2015.1057563
– volume: 19
  start-page: 19
  year: 2019
  ident: 1309_CR222
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.8b02689
– volume: 37
  start-page: 657
  year: 2019
  ident: 1309_CR319
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0095-1
– volume: 527
  start-page: 110
  year: 2015
  ident: 1309_CR93
  publication-title: Nature
  doi: 10.1038/nature15544
– volume: 21
  start-page: 6461
  year: 2020
  ident: 1309_CR129
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms21186461
– volume: 11
  start-page: 9833
  year: 2021
  ident: 1309_CR202
  publication-title: Theranostics
  doi: 10.7150/thno.62449
– volume: 550
  start-page: 407
  year: 2017
  ident: 1309_CR103
  publication-title: Nature
  doi: 10.1038/nature24268
– volume: 27
  start-page: 1737
  year: 2019
  ident: 1309_CR72
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2019.07.002
– volume: 21
  start-page: 914
  year: 2015
  ident: 1309_CR249
  publication-title: Nat. Med.
  doi: 10.1038/nm.3910
– volume: 30
  start-page: 2942
  year: 2022
  ident: 1309_CR171
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2022.07.001
– volume: 35
  start-page: 95
  year: 2017
  ident: 1309_CR316
  publication-title: Biotechnol. Adv.
  doi: 10.1016/j.biotechadv.2016.12.003
– volume: 181
  start-page: 136
  year: 2020
  ident: 1309_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.023
– volume: 37
  start-page: 75
  year: 2018
  ident: 1309_CR95
  publication-title: EMBO J.
  doi: 10.15252/embj.201796474
– volume: 114
  start-page: 5443
  year: 2017
  ident: 1309_CR89
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1619926114
– volume: 23
  start-page: 9862
  year: 2022
  ident: 1309_CR169
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms23179862
– volume: 325
  start-page: 52
  year: 2020
  ident: 1309_CR245
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2020.06.032
– volume: 74
  start-page: 1494
  year: 2019
  ident: 1309_CR271
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2019.07.063
– volume: 252
  start-page: 120094
  year: 2020
  ident: 1309_CR344
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2020.120094
– volume: 529
  start-page: 490
  year: 2016
  ident: 1309_CR342
  publication-title: Nature
  doi: 10.1038/nature16526
– volume: 10
  start-page: 977
  year: 2013
  ident: 1309_CR322
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2598
– volume: 20
  start-page: 298
  year: 2021
  ident: 1309_CR139
  publication-title: Mol. Ther. Methods Clin. Dev.
  doi: 10.1016/j.omtm.2020.12.001
– volume: 107
  start-page: 10220
  year: 2010
  ident: 1309_CR185
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1001673107
– volume: 66
  start-page: 1021
  year: 2009
  ident: 1309_CR156
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-009-8739-9
– volume: 14
  start-page: 2058
  year: 2022
  ident: 1309_CR237
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.1c21595
– volume: 25
  start-page: 229
  year: 2019
  ident: 1309_CR306
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0327-9
– volume: 168
  start-page: 55
  year: 2021
  ident: 1309_CR86
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.03.001
– volume: 523
  start-page: 481
  year: 2015
  ident: 1309_CR341
  publication-title: Nature
  doi: 10.1038/nature14592
– volume: 12
  year: 2021
  ident: 1309_CR329
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-26518-y
– volume: 321
  start-page: 960
  year: 2008
  ident: 1309_CR46
  publication-title: Science
  doi: 10.1126/science.1159689
– volume: 48
  start-page: 5684
  year: 2020
  ident: 1309_CR177
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa269
– volume: 28
  start-page: 10
  year: 2021
  ident: 1309_CR261
  publication-title: Drug Deliv.
  doi: 10.1080/10717544.2020.1850917
– volume: 47
  start-page: 5163
  year: 2008
  ident: 1309_CR201
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.200800963
– volume: 17
  start-page: 36
  year: 2016
  ident: 1309_CR19
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2015.2
– volume: 471
  start-page: 602
  year: 2011
  ident: 1309_CR55
  publication-title: Nature
  doi: 10.1038/nature09886
– volume: 31
  start-page: e1905751
  year: 2019
  ident: 1309_CR207
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201905751
– volume: 20
  start-page: 125
  year: 2021
  ident: 1309_CR241
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-00091-3
– volume: 34
  start-page: e00228
  year: 2021
  ident: 1309_CR290
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00228-20
– volume: 4
  start-page: 220
  year: 2013
  ident: 1309_CR62
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.06.020
– volume: 49
  start-page: 969
  year: 2021
  ident: 1309_CR21
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1251
– volume: 170
  start-page: 100
  year: 2022
  ident: 1309_CR141
  publication-title: J. Mol. Cell Cardiol.
  doi: 10.1016/j.yjmcc.2022.06.003
– volume: 24
  start-page: 1519
  year: 2018
  ident: 1309_CR262
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0209-1
– volume: 604
  start-page: 563
  year: 2022
  ident: 1309_CR254
  publication-title: Nature
  doi: 10.1038/s41586-022-04585-5
– volume: 31
  start-page: 397
  year: 2013
  ident: 1309_CR4
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2013.04.004
– volume: 7
  start-page: 305
  year: 2022
  ident: 1309_CR255
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-022-01151-3
– volume: 385
  start-page: 493
  year: 2021
  ident: 1309_CR31
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2107454
– volume: 16
  start-page: 145
  year: 2021
  ident: 1309_CR3
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev-pathmechdis-012419-032626
– volume: 76
  start-page: 359
  year: 2019
  ident: 1309_CR242
  publication-title: Mol. Cell.
  doi: 10.1016/j.molcel.2019.09.030
– volume: 31
  start-page: 822
  year: 2013
  ident: 1309_CR313
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2623
– volume: 47
  start-page: 4169
  year: 2019
  ident: 1309_CR120
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz184
– volume: 184
  start-page: 5635
  year: 2021
  ident: 1309_CR173
  publication-title: Cell
  doi: 10.1016/j.cell.2021.09.018
– volume: 350
  start-page: 401
  year: 2022
  ident: 1309_CR198
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2022.08.042
– volume: 139
  start-page: 163
  year: 2018
  ident: 1309_CR223
  publication-title: Adv. Cancer Res.
  doi: 10.1016/bs.acr.2018.05.001
– volume: 110
  start-page: 19012
  year: 2013
  ident: 1309_CR60
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1318481110
– volume: 28
  start-page: 202
  year: 2022
  ident: 1309_CR286
  publication-title: Clin. Microbiol. Infect.
  doi: 10.1016/j.cmi.2021.10.005
– volume: 12
  start-page: 204
  year: 2011
  ident: 1309_CR267
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2001
– volume: 4
  start-page: 52
  year: 2020
  ident: 1309_CR216
  publication-title: Nat. Biomed. Eng.
  doi: 10.1038/s41551-019-0502-4
– volume: 157
  start-page: 1262
  year: 2014
  ident: 1309_CR5
  publication-title: Cell
  doi: 10.1016/j.cell.2014.05.010
– volume: 9
  year: 2008
  ident: 1309_CR153
  publication-title: Genome Biol.
  doi: 10.1186/gb-2008-9-6-229
– volume: 20
  year: 2022
  ident: 1309_CR264
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-01233-4
– volume: 337
  start-page: 224
  year: 2021
  ident: 1309_CR232
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2021.07.032
– volume: 353
  start-page: aaf5573
  year: 2016
  ident: 1309_CR28
  publication-title: Science
  doi: 10.1126/science.aaf5573
– volume: 9
  year: 2018
  ident: 1309_CR101
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05477-x
– volume: 151
  start-page: 2551
  year: 2005
  ident: 1309_CR11
  publication-title: Microbiology
  doi: 10.1099/mic.0.28048-0
– volume: 29
  start-page: 207
  year: 2021
  ident: 1309_CR98
  publication-title: J. Adv. Res.
  doi: 10.1016/j.jare.2020.10.003
– volume: 361
  start-page: 1259
  year: 2018
  ident: 1309_CR115
  publication-title: Science
  doi: 10.1126/science.aas9129
– volume: 17
  start-page: 3413
  year: 2021
  ident: 1309_CR278
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.62506
– volume: 356
  start-page: 438
  year: 2017
  ident: 1309_CR182
  publication-title: Science
  doi: 10.1126/science.aam9321
– volume: 12
  start-page: 347
  year: 2013
  ident: 1309_CR211
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3978
– volume: 70
  start-page: 2123
  year: 2019
  ident: 1309_CR215
  publication-title: Hepatology
  doi: 10.1002/hep.30766
– volume: 339
  start-page: 819
  year: 2013
  ident: 1309_CR56
  publication-title: Science
  doi: 10.1126/science.1231143
– volume: 24
  start-page: 122
  year: 2014
  ident: 1309_CR65
  publication-title: Cell Res.
  doi: 10.1038/cr.2013.157
– volume: 45
  start-page: 6407
  year: 2006
  ident: 1309_CR163
  publication-title: Biochemistry
  doi: 10.1021/bi0522394
– volume: 153
  start-page: 910
  year: 2013
  ident: 1309_CR64
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.025
– volume: 13
  start-page: 187
  year: 2019
  ident: 1309_CR349
  publication-title: ACS Nano.
  doi: 10.1021/acsnano.8b05151
– volume: 133
  start-page: 916
  year: 2016
  ident: 1309_CR269
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000351
– volume: 156
  start-page: 935
  year: 2014
  ident: 1309_CR51
  publication-title: Cell
  doi: 10.1016/j.cell.2014.02.001
– volume: 16
  start-page: 587
  year: 2020
  ident: 1309_CR107
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/s41589-020-0490-4
– volume: 40
  start-page: 1807
  year: 2022
  ident: 1309_CR320
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-022-01377-0
– volume: 33
  start-page: 1293
  year: 2015
  ident: 1309_CR112
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3404
– volume: 20
  start-page: 101
  year: 2021
  ident: 1309_CR200
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-0090-8
– volume: 141
  start-page: 27
  year: 2010
  ident: 1309_CR99
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.016
– volume: 19
  start-page: 139
  year: 2020
  ident: 1309_CR186
  publication-title: Mol. Ther. Methods Clin. Dev.
  doi: 10.1016/j.omtm.2020.09.001
– volume: 16
  start-page: 203
  year: 2017
  ident: 1309_CR239
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2016.246
– volume: 609
  start-page: 191
  year: 2022
  ident: 1309_CR94
  publication-title: Nature
  doi: 10.1038/s41586-022-05114-0
– volume: 37
  start-page: 820
  year: 2019
  ident: 1309_CR166
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-019-0168-1
– volume: 172
  start-page: 112752
  year: 2021
  ident: 1309_CR289
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2020.112752
– volume: 4
  start-page: e204
  year: 2006
  ident: 1309_CR183
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.0040204
– volume: 598
  start-page: 120405
  year: 2021
  ident: 1309_CR229
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2021.120405
– volume: 351
  start-page: 84
  year: 2016
  ident: 1309_CR343
  publication-title: Science
  doi: 10.1126/science.aad5227
– volume: 13
  year: 2022
  ident: 1309_CR110
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-022-28900-w
– volume: 182
  start-page: 114108
  year: 2022
  ident: 1309_CR340
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2021.114108
– volume: 431
  start-page: 171
  year: 2018
  ident: 1309_CR181
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2018.05.042
– volume: 167
  start-page: 233
  year: 2016
  ident: 1309_CR150
  publication-title: Cell
  doi: 10.1016/j.cell.2016.08.056
– volume: 134
  start-page: 1385
  year: 2019
  ident: 1309_CR309
  publication-title: Blood
  doi: 10.1182/blood-2018-01-791400
– volume: 363
  start-page: eaau0629
  year: 2019
  ident: 1309_CR284
  publication-title: Science
  doi: 10.1126/science.aau0629
– volume: 37
  start-page: 38
  year: 2019
  ident: 1309_CR175
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2018.08.002
– volume: 551
  start-page: 464
  year: 2017
  ident: 1309_CR26
  publication-title: Nature
  doi: 10.1038/nature24644
– volume: 16
  start-page: e1907301
  year: 2020
  ident: 1309_CR178
  publication-title: Small
  doi: 10.1002/smll.201907301
– volume: 114
  start-page: 565
  year: 2014
  ident: 1309_CR268
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.114.300507
– volume: 38
  start-page: 824
  year: 2020
  ident: 1309_CR172
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0561-9
– volume: 27
  start-page: 440
  year: 2017
  ident: 1309_CR205
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.16
– volume: 39
  start-page: 35
  year: 2021
  ident: 1309_CR75
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0592-2
– volume: 17
  start-page: e2007593
  year: 2021
  ident: 1309_CR225
  publication-title: Small
  doi: 10.1002/smll.202007593
– volume: 76
  start-page: 1703
  year: 2020
  ident: 1309_CR270
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2020.07.061
– volume: 7
  start-page: 2715
  year: 2018
  ident: 1309_CR220
  publication-title: ACS Synth. Biol.
  doi: 10.1021/acssynbio.8b00192
– volume: 1
  start-page: e60
  year: 2005
  ident: 1309_CR49
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.0010060
– volume: 154
  start-page: 442
  year: 2013
  ident: 1309_CR59
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.044
– volume: 25
  start-page: 776
  year: 2019
  ident: 1309_CR296
  publication-title: Nat. Med.
  doi: 10.1038/s41591-019-0401-y
– volume: 119
  start-page: 70
  year: 2009
  ident: 1309_CR196
  publication-title: J. Clin. Invest.
– volume: 192
  start-page: 113642
  year: 2021
  ident: 1309_CR345
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/j.jpba.2020.113642
– ident: 1309_CR113
  doi: 10.1038/s41587-022-01410-2
– volume: 383
  start-page: 1492
  year: 2020
  ident: 1309_CR184
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMc2026172
– volume: 31
  start-page: e1802896
  year: 2019
  ident: 1309_CR212
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201802896
– volume: 7
  start-page: eabj0624
  year: 2021
  ident: 1309_CR233
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.abj0624
– volume: 24
  start-page: 521
  year: 2019
  ident: 1309_CR299
  publication-title: Heart Fail. Rev.
  doi: 10.1007/s10741-019-09776-3
– volume: 53
  start-page: 895
  year: 2021
  ident: 1309_CR331
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-021-00838-7
– volume: 29
  start-page: 13
  year: 2021
  ident: 1309_CR339
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2020.11.030
– volume: 7
  start-page: e40913
  year: 2012
  ident: 1309_CR57
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0040913
– volume: 17
  start-page: 5
  year: 2016
  ident: 1309_CR143
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2015.2
– volume: 15
  start-page: 905
  year: 2018
  ident: 1309_CR121
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1080/17425247.2018.1517746
– volume: 55
  start-page: 161
  year: 2021
  ident: 1309_CR85
  publication-title: Annu. Rev. Genet.
  doi: 10.1146/annurev-genet-071719-022559
– volume: 131
  start-page: 62
  year: 2009
  ident: 1309_CR53
  publication-title: Int. J. Food Microbiol.
  doi: 10.1016/j.ijfoodmicro.2008.05.030
– volume: 57
  start-page: 1491
  year: 2018
  ident: 1309_CR228
  publication-title: Angew. Chem. Int. Ed. Engl.
  doi: 10.1002/anie.201708689
– volume: 111
  start-page: 9798
  year: 2014
  ident: 1309_CR91
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1402597111
– volume: 41
  start-page: 7
  year: 2014
  ident: 1309_CR63
  publication-title: J. Genet. Genomics.
  doi: 10.1016/j.jgg.2013.12.004
– volume: 358
  start-page: 1019
  year: 2017
  ident: 1309_CR179
  publication-title: Science
  doi: 10.1126/science.aaq0180
– volume: 190
  start-page: 1390
  year: 2008
  ident: 1309_CR43
  publication-title: J. Bacteriol.
  doi: 10.1128/JB.01412-07
– volume: 8
  start-page: rbab033
  year: 2021
  ident: 1309_CR335
  publication-title: Regen. Biomater.
  doi: 10.1093/rb/rbab033
– volume: 11
  start-page: 614
  year: 2021
  ident: 1309_CR312
  publication-title: Theranostics
  doi: 10.7150/thno.47007
– volume: 41
  start-page: 1100
  year: 2020
  ident: 1309_CR287
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2020.10.004
– volume: 364
  start-page: 286
  year: 2019
  ident: 1309_CR317
  publication-title: Science
  doi: 10.1126/science.aav9023
– volume: 163
  start-page: 759
  year: 2015
  ident: 1309_CR133
  publication-title: Cell
  doi: 10.1016/j.cell.2015.09.038
– volume: 86
  start-page: 1036
  year: 2015
  ident: 1309_CR301
  publication-title: J. Neurol. Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2014-308724
– volume: 17
  start-page: 85
  year: 1995
  ident: 1309_CR36
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1995.mmi_17010085.x
– volume: 38
  start-page: 883
  year: 2020
  ident: 1309_CR164
  publication-title: Nat. Biotechnol.
  doi: 10.1038/s41587-020-0453-z
– volume: 21
  start-page: 440
  year: 2018
  ident: 1309_CR324
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-017-0060-6
– volume: 109
  start-page: E2579
  year: 2012
  ident: 1309_CR48
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1208507109
– volume: 22
  start-page: 757
  year: 2021
  ident: 1309_CR288
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-021-00408-x
– volume: 182
  start-page: 185
  year: 2021
  ident: 1309_CR73
  publication-title: Prog. Mol. Biol. Transl. Sci.
  doi: 10.1016/bs.pmbts.2020.12.018
– volume: 15
  start-page: 20
  year: 2022
  ident: 1309_CR294
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-022-01237-z
SSID ssj0001637754
ssib046561479
ssib044760960
ssib048695610
Score 2.6446683
SecondaryResourceType review_article
Snippet Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future...
Abstract Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 36
SubjectTerms 631/61/2300
692/4017
Cancer Research
Cell Biology
Clinical trials
CRISPR
CRISPR-Cas Systems - genetics
Disease
Gene Editing
Genetic Therapy - methods
Genome editing
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Pathology
Review
Review Article
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8QwEA7iyYuo66O-qCBetGzbpGnibV2UVVBkVdhbSNIEBa1idw_-eydpd931efHYJqXDZJL5kpl8g9C-ziXA8kJHGHMdESpJpMCTRa52Ec04OECfjHl5RXt35GKQDaZKfbmcsJoeuFZc29ostxhTCmssSbhWutASxxIcmyaYebJt8HlTmyl_ukKxo3ZrbsnEmLUrWK1domXq0odcWCGf8USesP87lPk1WfJTxNQ7orMltNggyLBTS76M5ky5glqdEnbPT2_hQehzOv1heQvF3f75zXW_3ZUVD6euWlXHoU_MgmUulGXhHvyVy2oV3Z2d3nZ7UVMjIdKw9RhGlnIuTeKOdtNMplZzqVRWMJ67ErxZaovYWCIBVjliGINjqxIT6zRNqLWw0OE1NF8-l2YDhRprqkDH0OB4-AoF0MIqTqxRBEAMC1Ay1pfQDYG4q2PxKHwgGzNR61iAjoXXscgDdDj55qWmz_i194kbhklPR33tX4BBiMYgxF8GEaDt8SCKZj5WIs0BaTHKeBKgvUkzzCQXHpGleR75PgDPACKBHOv1mE8kgd8RShm05DPWMCPqbEv5cO_ZujkjjsUxQEdju_kQ62dVbP6HKrbQQlobfJTQbTQ_fB2ZHcBQQ7Xrp8s7dHITYQ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: HAS SpringerNature Open Access 2022
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1NT9wwEB1RkKpeqpavhgJKpYoLjUhsx7F7W1YgWIkKQZG4WbZjt5XabEWWA_--YydZui0gcUw8USbjsefFM34G-GgrjbC8thml0maMa5YZjGRZOLuIlxIDYCzGPPvCT67Y5Lq8XgIy7IWJRfuR0jJO00N12EGLk22okySh-idkBaoXsBKo2tG3V0ajyeXkfmWF00Dr1u-Qyal44OGFKBTJ-h9CmP8XSv6TLY1B6PgNvO7RYzrq9H0LS65ZhbURfsr01126l8Z6zrhQvgovz_q0-Rrk44vTy_OLg7FuZfrXjqv2cxrrs3C2S3VTh4u487Jdh6vjo6_jk6w_KiGz-AcyyzyXUrsirPCSUhNvpTamrIWswkm8JfF17jzTiK4CP4yjuTeFyy0hBfce5zu6AcvNtHHvILXUcoNxHRsCHV9tEGF4I5l3hiGWEQkUg-mU7XnEw3EWP1XMZ1OhOnMrNLeK5lZVAvvzZ353LBpPSh-GHplLBgbseGN68031HqG8LytPKecYe1khrbG11TTXCHgso4InsD30p-qHZatIhYBLcCGLBD7Mm3FAhSyJbtz0NsogSkOkhHpsdt0_1wRfxzgX2FItOMaCqostzY_vkbRbChbIHBP4NLjQvVqPm2LreeLv4RXpvDwr-DYsz25u3Q6CppnZ7UfJH-dSDYc
  priority: 102
  providerName: Springer Nature
Title CRISPR/Cas9 therapeutics: progress and prospects
URI https://link.springer.com/article/10.1038/s41392-023-01309-7
https://www.ncbi.nlm.nih.gov/pubmed/36646687
https://www.proquest.com/docview/2765886891
https://www.proquest.com/docview/2766430817
https://pubmed.ncbi.nlm.nih.gov/PMC9841506
https://doaj.org/article/ff57f3366212419cbcdca30a822c4386
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwELdge-EFDcZHxqiChHiBqEnsODYvqIs6jUqbpo5JfbNsxx5IkI6le-CFv507J00pH3tplNhVnPP57ue78x0hr22pAZbXNqFU2oRxzRIDmizB2kW8kKAAQzDm6Rk_uWSzRbHoDW5tH1a5lolBUNdLizbycV6CrhRcyOzD9fcEq0ahd7UvoXGf7GLqMuTqcjGoU8ZKjgh9uOeY9nLjlWKCywE-BJsMp5gQDuvRpVjCEDaO_TmblIpxC_IeQzVzDEBCx0S5pctCyv9_4dS_wy3_8LkGVXa8Rx72GDSedEzziNxzzWOyP2lg__3tR_wmDlGhwdy-T9Jq_vHifD6udCvj3w5rte_jENoFgjLWTY034dBm-4RcHk8_VSdJX2UhsbB5WSWeS6ldhsbhvNC5t1IbU9RClljEt8h9nTrPNAAzTC3jaOpN5lKb5xn3HkQlfUp2mmXjnpPYUssNQAJoQOLWBsCJN5J5ZxjAIBGRbE0vZfsU5FgJ46sKrnAqVEdjBTRWgcaqjMjb4T_XXQKOO3sf4TQMPTF5dniwvLlS_VpU3help5RzUNssk9bY2mqaasBKllHBI3K4nkTVr-hWbfgvIq-GZliL6GDRjVvehj4A8ABkwTiedXM-jARexzgX0FJuccPWULdbmi-fQ75vKRjmgYzIuzXfbIb1f1Ic3P0VL8iDvGPlJOOHZGd1c-teAr5amVFYRCOyO5nMLmZwPZqenc_hacWrUbBZwO_pz-kvyCQeOw
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKOcAFAeWxpUCQgAtEm8SOYyMhVBaqXfoQKq20N9d2bKgE2dJshfqn-I3MOI9lefTWY2InccbjmW884xlCntpCAywvbUyptDHjmsUGNFmMtYt4LkEBhmDM3T0-PmQfpvl0hfzszsJgWGUnE4OgLmcW98iHWQG6UnAh0zcn32OsGoXe1a6ERsMW2-78B5hs9evJO5jfZ1m29f5gNI7bqgKxBbA-jz2XUrsUN0OzXGfeSm1MXgpZYNHaPPNl4jzTAEQwlYqjiTepS2yWpdx7EA0U3nuFXAXFm6CxV0x79c1YwdEi6K85ptlceMGY4LKHK2EPiFNMQIf17xIsmQiGanuuJ6FiWIN-wdDQDAOe0BFSLOnOUGLgX7j47_DOP3y8QXVu3SQ3WswbbTZMeousuOo2WduswN7_dh49j0IUatjeXyPJaH_y6eP-cKRrGf12OKx-FYVQMhDMka5KvAiHROs75PBS6H-XrFazyt0nkaWWG4Ag0IDELQ2AIW8k884wgF1iQNKOXsq2Kc-x8sZXFVzvVKiGxgporAKNVTEgL_pnTpqEHxf2fovT0PfEZN3hxuz0s2rXvvI-LzylnANMYKm0xpZW00QDNrOMCj4gG90kqlaC1GrB7wPypG-GtY8OHV252VnoA4ASQB2M414z5_1I4HOMcwEtxRI3LA11uaU6_hLyi0vBMO_kgLzs-GYxrP-TYv3iv3hMro0PdnfUzmRv-wG5njVsHad8g6zOT8_cQ8B2c_MoLKiIHF32Cv4Fm8JTvQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTkK8IGB8dAwIEvACUZPYcWIkhLZu1cqgqgqT9uY5TgyTIB1LJ7R_jb-OO-ejlI-97TG12zp357vf-c53AM9MohGW58ZnTBqfC839DC2ZT72LRCzRALpkzA8TsX_I3x3FR2vws70LQ2mVrU50ijqfGzojH0QJ2spUpDIc2CYtYro7env63acOUhRpbdtp1CJyUFz8QPetejPeRV4_j6LR3qfhvt90GPANAveFb4WUugjpYDSKdWSN1FkW56lMqIFtHNk8KCzXCEqorErBApuFRWCiKBTWoppg-LvXYD0hr6gH6zt7k-mslWbOE0H-QfcsqOjmMibGUyE78OJOhASjcnTUDS-gBorotja3fAKWDiq0NpQoGlH6E4VFkhVL6hoO_Asl_53s-UfE1xnS0S242SBgb7sW2duwVpR3YGO7RO__24X3wnM5qe6wfwOC4Wz8cTobDHUlvd-uilWvPZdYhmra02VOD-7KaHUXDq-EA_egV87L4gF4hhmRISDBASJuniE0spnktsg4grC0D2FLL2WaAujUh-OrcoF4lqqaxgpprByNVdKHl913TuvyH5fO3iE2dDOpdLf7YH72WTWaQFkbJ5YxIRA08FCazORGs0AjUjOcpaIPWy0TVaNPKrWU_j487YZRE1B4R5fF_NzNQXiJEA_Xcb_mebcS_DsuRIojyYo0rCx1daQ8-eKqjcuUUxXKPrxq5Wa5rP-TYvPyt3gC13H3qvfjycFDuBHVUu2HYgt6i7Pz4hECvUX2uNlRHhxf9Sb-BQqjWVg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CRISPR%2FCas9+therapeutics%3A+progress+and+prospects&rft.jtitle=Signal+transduction+and+targeted+therapy&rft.au=Li%2C+Tianxiang&rft.au=Yang%2C+Yanyan&rft.au=Qi%2C+Hongzhao&rft.au=Cui%2C+Weigang&rft.date=2023-01-16&rft.pub=Nature+Publishing+Group&rft.issn=2095-9907&rft.eissn=2059-3635&rft.volume=8&rft.issue=1&rft.spage=36&rft_id=info:doi/10.1038%2Fs41392-023-01309-7&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2059-3635&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2059-3635&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2059-3635&client=summon