Formulation, Characterization, and Antitumor Properties of Trans- and Cis-Citral in the 4T1 Breast Cancer Xenograft Mouse Model

• Published in: Pharmaceutical research Vol. 32; no. 8; pp. 2548 - 2558
• Main Authors: Zeng, San, Kapur, Arvinder, Patankar, Manish S., Xiong, May P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2015; Springer Nature B.V
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - therapeutic use; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Breast cancer; Breast Neoplasms - drug therapy; Cell Survival; Chemistry, Pharmaceutical; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - therapeutic use; Female; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Medical Law; Mice; Mice, Inbred BALB C; Micelles; Monoterpenes - administration & dosage; Monoterpenes - chemistry; Monoterpenes - therapeutic use; Pharmacology/Toxicology; Pharmacy; Research Paper; Stereoisomerism; Studies; Tissues; Tumors; Xenograft Model Antitumor Assays; micelle; breast cancer; citral; geranial; neral

Purpose Citral is composed of a random mixture of two geometric stereoisomers geranial ( trans -citral) and neral ( cis -citral) yet few studies have directly compared their in vivo antitumor properties. A micelle formulation was therefore developed. Methods Geranial and neral were synthesized. Comm...