Assessment of global health risk of antibiotic resistance genes

• Published in: Nature communications Vol. 13; no. 1; pp. 1553 - 11
• Main Authors: Zhang, Zhenyan, Zhang, Qi, Wang, Tingzhang, Xu, Nuohan, Lu, Tao, Hong, Wenjie, Penuelas, Josep, Gillings, Michael, Wang, Meixia, Gao, Wenwen, Qian, Haifeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.03.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/158; 631/326/107; 631/326/171; 631/326/2565/2142; 692/499; Accessibility; Animal health; Animals; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Aquatic habitats; Availability; Drug resistance; Drug Resistance, Microbial - genetics; Evaluation; Genes; Genes, Bacterial; Global Health; Habitats; Health risk assessment; Health risks; Humanities and Social Sciences; Learning algorithms; Machine learning; Metagenome; Metagenomics; Microorganisms; Mobility; multidisciplinary; Multidrug resistance; Pathogenicity; Pathogens; Public health; Risk assessment; Science; Science (multidisciplinary)

Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many genes can confer resistance, but evaluating the relative health risks of ARGs is complex. Factors such as the abundance, propensity for lateral transmission and ability of ARGs to be expres...