Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome

• Published in: Nature communications Vol. 11; no. 1; p. 4995
• Main Authors: Hollis, Robert L., Thomson, John P., Stanley, Barbara, Churchman, Michael, Meynert, Alison M., Rye, Tzyvia, Bartos, Clare, Iida, Yasushi, Croy, Ian, Mackean, Melanie, Nussey, Fiona, Okamoto, Aikou, Semple, Colin A., Gourley, Charlie, Herrington, C. Simon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 13; 13/51; 14; 14/63; 45; 45/23; 631/67; 631/67/1517; 631/67/1517/1709; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Endometrioid - genetics; Carcinoma, Endometrioid - metabolism; Carcinoma, Endometrioid - mortality; Carcinoma, Endometrioid - pathology; Complexity; Diagnosis; DNA Copy Number Variations; Female; Heterogeneity; Humanities and Social Sciences; Humans; MAP kinase; Microsatellite Instability; Middle Aged; Mismatch repair; multidisciplinary; Mutation; Ovarian cancer; Ovarian carcinoma; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Ovaries; p53 Protein; Prognosis; PTEN protein; Science; Science (multidisciplinary); Signal Transduction; Taxonomy; Whole Exome Sequencing; Wnt protein

Endometrioid ovarian carcinoma (EnOC) demonstrates substantial clinical and molecular heterogeneity. Here, we report whole exome sequencing of 112 EnOC cases following rigorous pathological assessment. We detect a high frequency of mutation in CTNNB1 (43%), PIK3CA (43%), ARID1A (36%), PTEN (29%),  K...