Sensory deprivation in Staphylococcus aureus

• Published in: Nature communications Vol. 9; no. 1; pp. 523 - 12
• Main Authors: Villanueva, Maite, García, Begoña, Valle, Jaione, Rapún, Beatriz, Ruiz de los Mozos, Igor, Solano, Cristina, Martí, Miguel, Penadés, José R., Toledo-Arana, Alejandro, Lasa, Iñigo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.02.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/43; 631/326/325/2482; 631/326/41; 631/80/86; 96/95; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cues; Environmental changes; Environmental conditions; Gene Expression Regulation, Bacterial; Genomes; Humanities and Social Sciences; Humans; multidisciplinary; Niches; Pathogens; Replication; Science; Science (multidisciplinary); Sensory deprivation; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - genetics; Staphylococcus aureus - growth & development; Staphylococcus aureus - physiology

Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. The core genome of the major human pathogen Staphylococcus aureus encodes 16 TCSs, one of which (WalRK) is essential. Here we show that S. aureus can be deprived of its complete sensorial TCS network and still s...