Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma

• Published in: Nature communications Vol. 10; no. 1; pp. 5076 - 13
• Main Authors: Su, Dan, Zhang, Dadong, Jin, Jiaoyue, Ying, Lisha, Han, Miao, Chen, Kaiyan, Li, Bin, Wu, Junzhou, Xie, Zhenghua, Zhang, Fanrong, Lin, Yihui, Cheng, Guoping, Li, Jing-Yu, Huang, Minran, Wang, Jinchao, Wang, Kailai, Zhang, Jianjun, Li, Fugen, Xiong, Lei, Futreal, Andrew, Mao, Weimin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.11.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 38/91; 45/23; 49/98; 631/154/53/2423; 631/1647/767/70; 631/67/1504/1477; 631/67/69; 692/4020/1503/1476/1477; 82/1; 82/51; Adult; Aged; Aminopyridines - therapeutic use; Biomarkers; Biomarkers, Tumor - genetics; Biotechnology; Cancer; Cell culture; Cell Line, Tumor; Cyclin-dependent kinase 4; Cyclin-Dependent Kinase 4 - antagonists & inhibitors; Cyclin-Dependent Kinase 6 - antagonists & inhibitors; Cyclin-Dependent Kinase Inhibitor p15 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Drug Resistance, Neoplasm; Drug screening; Encyclopedias; Esophageal cancer; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - genetics; Esophageal Squamous Cell Carcinoma - drug therapy; Esophageal Squamous Cell Carcinoma - genetics; Esophagus; Female; Humanities and Social Sciences; Humans; Male; Middle Aged; multidisciplinary; Mutation; Piperazines - therapeutic use; Prognosis; Protein Kinase Inhibitors - therapeutic use; Purines - therapeutic use; Pyridines - therapeutic use; Science; Science (multidisciplinary); Sensitivity; Squamous cell carcinoma; Xenograft Model Antitumor Assays; Xenografts; Xenotransplantation

Previous studies from the Cancer Cell Line Encyclopedia (CCLE) project have adopted commercial pan-cancer cell line models to identify drug sensitivity biomarkers. However, drug sensitivity biomarkers in esophageal squamous cell carcinoma (ESCC) have not been widely explored. Here, eight patient-der...