Cell-fate transition and determination analysis of mouse male germ cells throughout development

• Published in: Nature communications Vol. 12; no. 1; pp. 6839 - 20
• Main Authors: Zhao, Jiexiang, Lu, Ping, Wan, Cong, Huang, Yaping, Cui, Manman, Yang, Xinyan, Hu, Yuqiong, Zheng, Yi, Dong, Ji, Wang, Mei, Zhang, Shu, Liu, Zhaoting, Bian, Shuhui, Wang, Xiaoman, Wang, Rui, Ren, Shaofang, Wang, Dazhuang, Yao, Zhaokai, Chang, Gang, Tang, Fuchou, Zhao, Xiao-Yang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.11.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/100; 13/31; 13/44; 13/89; 38/39; 38/91; 631/136/2434; 631/1647/514/2254; 631/80/641/1655; 64/60; 692/699/2732/1577; Ablation; Animals; Cell cycle; Gene Expression Regulation, Developmental; Germ cells; Humanities and Social Sciences; Humans; Infertility; Male; Males; Meiosis - genetics; Mice; Mitosis - genetics; multidisciplinary; Receptors, Notch - genetics; Receptors, Notch - metabolism; Reconfiguration; Regulation; Science; Science (multidisciplinary); Signal Transduction; Spermatogenesis - genetics; Spermatozoa - cytology; Spermatozoa - growth & development; Spermatozoa - metabolism; Transcriptome; Transcriptomes; Zebrafish

Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell...