Cell-fate transition and determination analysis of mouse male germ cells throughout development

Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell...

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Published inNature communications Vol. 12; no. 1; pp. 6839 - 20
Main Authors Zhao, Jiexiang, Lu, Ping, Wan, Cong, Huang, Yaping, Cui, Manman, Yang, Xinyan, Hu, Yuqiong, Zheng, Yi, Dong, Ji, Wang, Mei, Zhang, Shu, Liu, Zhaoting, Bian, Shuhui, Wang, Xiaoman, Wang, Rui, Ren, Shaofang, Wang, Dazhuang, Yao, Zhaokai, Chang, Gang, Tang, Fuchou, Zhao, Xiao-Yang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.11.2021
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/100
13/31
13/44
13/89
38/39
38/91
631/136/2434
631/1647/514/2254
631/80/641/1655
64/60
692/699/2732/1577
Ablation
Animals
Cell cycle
Gene Expression Regulation, Developmental
Germ cells
Humanities and Social Sciences
Humans
Infertility
Male
Males
Meiosis - genetics
Mice
Mitosis - genetics
multidisciplinary
Receptors, Notch - genetics
Receptors, Notch - metabolism
Reconfiguration
Regulation
Science
Science (multidisciplinary)
Signal Transduction
Spermatogenesis - genetics
Spermatozoa - cytology
Spermatozoa - growth & development
Spermatozoa - metabolism
Transcriptome
Transcriptomes
Zebrafish
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Abstract Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell-fate transition from mitotic to post-mitotic primordial germ cells is accompanied by transcriptome-scale reconfiguration and a transitional cell state. Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells’ identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulation for proper cell-fate transition. Finally, systematic human-mouse comparison reveals potential regulators whose deficiency contributed to human male infertility via mitotic arrest regulation. Collectively, our study provides an accurate and comprehensive transcriptome atlas of the male germline cycle and allows for an in-depth understanding of the cell-fate transition and determination underlying male germ cell development. The full-term developmental profile of male germ cells remains undefined. Here, the authors use single-cell sequencing to investigate the transcriptome landscapes of mouse male germ cells throughout development and find several critical regulators for prenatal cell-fate determination.
AbstractList Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell-fate transition from mitotic to post-mitotic primordial germ cells is accompanied by transcriptome-scale reconfiguration and a transitional cell state. Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells' identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulation for proper cell-fate transition. Finally, systematic human-mouse comparison reveals potential regulators whose deficiency contributed to human male infertility via mitotic arrest regulation. Collectively, our study provides an accurate and comprehensive transcriptome atlas of the male germline cycle and allows for an in-depth understanding of the cell-fate transition and determination underlying male germ cell development.
Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell-fate transition from mitotic to post-mitotic primordial germ cells is accompanied by transcriptome-scale reconfiguration and a transitional cell state. Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells’ identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulation for proper cell-fate transition. Finally, systematic human-mouse comparison reveals potential regulators whose deficiency contributed to human male infertility via mitotic arrest regulation. Collectively, our study provides an accurate and comprehensive transcriptome atlas of the male germline cycle and allows for an in-depth understanding of the cell-fate transition and determination underlying male germ cell development. The full-term developmental profile of male germ cells remains undefined. Here, the authors use single-cell sequencing to investigate the transcriptome landscapes of mouse male germ cells throughout development and find several critical regulators for prenatal cell-fate determination.
Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell-fate transition from mitotic to post-mitotic primordial germ cells is accompanied by transcriptome-scale reconfiguration and a transitional cell state. Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells’ identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulation for proper cell-fate transition. Finally, systematic human-mouse comparison reveals potential regulators whose deficiency contributed to human male infertility via mitotic arrest regulation. Collectively, our study provides an accurate and comprehensive transcriptome atlas of the male germline cycle and allows for an in-depth understanding of the cell-fate transition and determination underlying male germ cell development.The full-term developmental profile of male germ cells remains undefined. Here, the authors use single-cell sequencing to investigate the transcriptome landscapes of mouse male germ cells throughout development and find several critical regulators for prenatal cell-fate determination.
Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell-fate transition from mitotic to post-mitotic primordial germ cells is accompanied by transcriptome-scale reconfiguration and a transitional cell state. Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells' identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulation for proper cell-fate transition. Finally, systematic human-mouse comparison reveals potential regulators whose deficiency contributed to human male infertility via mitotic arrest regulation. Collectively, our study provides an accurate and comprehensive transcriptome atlas of the male germline cycle and allows for an in-depth understanding of the cell-fate transition and determination underlying male germ cell development.Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined. Here, by interrogating the high-precision transcriptome atlas of 11,598 cells covering 28 critical time-points, we demonstrate that cell-fate transition from mitotic to post-mitotic primordial germ cells is accompanied by transcriptome-scale reconfiguration and a transitional cell state. Notch signaling pathway is essential for initiating mitotic arrest and the maintenance of male germ cells' identities. Ablation of HELQ induces developmental arrest and abnormal transcriptome reprogramming of male germ cells, indicating the importance of cell cycle regulation for proper cell-fate transition. Finally, systematic human-mouse comparison reveals potential regulators whose deficiency contributed to human male infertility via mitotic arrest regulation. Collectively, our study provides an accurate and comprehensive transcriptome atlas of the male germline cycle and allows for an in-depth understanding of the cell-fate transition and determination underlying male germ cell development.
The full-term developmental profile of male germ cells remains undefined. Here, the authors use single-cell sequencing to investigate the transcriptome landscapes of mouse male germ cells throughout development and find several critical regulators for prenatal cell-fate determination.
ArticleNumber 6839
Author Yao, Zhaokai
Tang, Fuchou
Wan, Cong
Zheng, Yi
Bian, Shuhui
Chang, Gang
Wang, Xiaoman
Cui, Manman
Zhao, Xiao-Yang
Dong, Ji
Wang, Rui
Wang, Dazhuang
Huang, Yaping
Hu, Yuqiong
Liu, Zhaoting
Zhao, Jiexiang
Wang, Mei
Ren, Shaofang
Yang, Xinyan
Zhang, Shu
Lu, Ping
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34824237$$D View this record in MEDLINE/PubMed
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Snippet Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains...
The full-term developmental profile of male germ cells remains undefined. Here, the authors use single-cell sequencing to investigate the transcriptome...
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SubjectTerms 13/1
13/100
13/31
13/44
13/89
38/39
38/91
631/136/2434
631/1647/514/2254
631/80/641/1655
64/60
692/699/2732/1577
Ablation
Animals
Cell cycle
Gene Expression Regulation, Developmental
Germ cells
Humanities and Social Sciences
Humans
Infertility
Male
Males
Meiosis - genetics
Mice
Mitosis - genetics
multidisciplinary
Receptors, Notch - genetics
Receptors, Notch - metabolism
Reconfiguration
Regulation
Science
Science (multidisciplinary)
Signal Transduction
Spermatogenesis - genetics
Spermatozoa - cytology
Spermatozoa - growth & development
Spermatozoa - metabolism
Transcriptome
Transcriptomes
Zebrafish
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Title Cell-fate transition and determination analysis of mouse male germ cells throughout development
URI https://link.springer.com/article/10.1038/s41467-021-27172-0
https://www.ncbi.nlm.nih.gov/pubmed/34824237
https://www.proquest.com/docview/2602346297
https://www.proquest.com/docview/2604013184
https://pubmed.ncbi.nlm.nih.gov/PMC8617176
https://doaj.org/article/a64005ac6c2348c19b9171c05c36885e
Volume 12
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