Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test
OBJECTIVE:--To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS--A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70...
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| Published in | Diabetes care Vol. 30; no. 1; pp. 89 - 94 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Alexandria, VA
American Diabetes Association
2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | OBJECTIVE:--To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS--A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m²) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis. RESULTS:--The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose₀₋₃₀[AUC] x insulin₀₋₃₀[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt [divide sign] I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001). CONCLUSIONS:--Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. |
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| AbstractList | OBJECTIVE—To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT).
RESEARCH DESIGN AND METHODS—A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18–70 years, BMI 20–65 kg/m2) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis.
RESULTS—The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose0–30[AUC] × insulin0–30[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin × basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt ÷ I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001).
CONCLUSIONS—Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. OBJECTIVE:--To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS--A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m²) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis. RESULTS:--The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose₀₋₃₀[AUC] x insulin₀₋₃₀[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt [divide sign] I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001). CONCLUSIONS:--Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m^sup 2^) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis. The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose^sub 0-30^[AUC] × insulin^sub 0-30^[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin × basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt ÷ I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001). Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m(2)) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis. The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose(0-30)[AUC] x insulin(0-30)[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt / I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001). Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT).OBJECTIVETo derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT).A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m(2)) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis.RESEARCH DESIGN AND METHODSA total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18-70 years, BMI 20-65 kg/m(2)) with normal glucose tolerance (n = 100) or impaired glucose tolerance (n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis.The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose(0-30)[AUC] x insulin(0-30)[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt / I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001).RESULTSThe product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose(0-30)[AUC] x insulin(0-30)[AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin x basal endogenous glucose production) (r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt / I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp (P = 0.78, P < 0.0001).Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects.CONCLUSIONSNovel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test Muhammad A. Abdul-Ghani , MD, PHD , Masafumi Matsuda , MD , Bogdan Balas , MD and Ralph A. DeFronzo , MD From the Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas Address correspondence and reprint requests to Ralph A. DeFronzo, MD, Diabetes Division, University of Texas Health Science Center, 7703 Floyd Curl Dr., MS 7886, San Antonio, TX 78229. E-mail: albarado{at}uthscsa.edu Abstract OBJECTIVE —To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance test (OGTT). RESEARCH DESIGN AND METHODS —A total of 155 subjects of Mexican-American origin (58 male and 97 female, aged 18–70 years, BMI 20–65 kg/m 2 ) with normal glucose tolerance ( n = 100) or impaired glucose tolerance ( n = 55) were studied. Each subject received a 75-g OGTT and a euglycemic insulin clamp in combination with tritiated glucose. The OGTT-derived indexes of muscle and hepatic insulin sensitivity were compared with hepatic and muscle insulin sensitivity, which was directly measured with the insulin clamp, by correlation analysis. RESULTS —The product of total area under curve (AUC) for glucose and insulin during the first 30 min of the OGTT (glucose 0–30 [AUC] × insulin 0–30 [AUC]) strongly correlated with the hepatic insulin resistance index (fasting plasma insulin × basal endogenous glucose production) ( r = 0.64, P < 0.0001). The rate of decay of plasma glucose concentration from its peak value to its nadir during the OGTT divided by the mean plasma insulin concentration (dG/dt ÷ I) strongly correlated with muscle insulin sensitivity measured with the insulin clamp ( P = 0.78, P < 0.0001). CONCLUSIONS —Novel estimates for hepatic and muscle insulin resistance from OGTT data are presented for quantitation of insulin sensitivity in nondiabetic subjects. AUC, area under the curve EGP, endogenous glucose production FPI, fasting plasma insulin HGP, hepatic glucose production HOMA, homeostasis model assessment IGT, impaired glucose tolerance NGT, normal glucose tolerance OGTT, oral glucose tolerance test QUICKI, quantitative insulin sensitivity index Footnotes A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Accepted October 13, 2006. Received June 19, 2006. DIABETES CARE |
| Audience | Professional |
| Author | Matsuda, Masafumi Balas, Bogdan Abdul-Ghani, Muhammad A DeFronzo, Ralph A |
| Author_xml | – sequence: 1 fullname: Abdul-Ghani, Muhammad A – sequence: 2 fullname: Matsuda, Masafumi – sequence: 3 fullname: Balas, Bogdan – sequence: 4 fullname: DeFronzo, Ralph A |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18439518$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/17192339$$D View this record in MEDLINE/PubMed |
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| Snippet | OBJECTIVE:--To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral... Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test Muhammad A. Abdul-Ghani , MD, PHD , Masafumi Matsuda , MD , Bogdan... OBJECTIVE—To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose... To derive indexes for muscle and hepatic insulin sensitivity from the measurement of plasma glucose and insulin concentrations during an oral glucose tolerance... |
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| SubjectTerms | Adolescent Adult Aged Biological and medical sciences blood blood glucose body mass index Cardiovascular disease Diabetes Diabetes. Impaired glucose tolerance Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies fasting Glucose Glucose Intolerance Glucose Intolerance - physiopathology glucose tolerance Glucose Tolerance Test Glucose tolerance tests Glycemic index Health aspects Hispanic Americans Hispanic or Latino Humans Hyperglycemia Insulin Insulin - blood Insulin resistance Insulin Resistance - physiology liver Liver - physiology Liver - physiopathology Measurement Medical sciences Mexican Americans Middle Aged Muscle, Skeletal Muscle, Skeletal - physiology Muscle, Skeletal - physiopathology physiology physiopathology Reference Values tritium |
| Title | Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test |
| URI | http://care.diabetesjournals.org/content/30/1/89.abstract https://www.ncbi.nlm.nih.gov/pubmed/17192339 https://www.proquest.com/docview/223040013 https://www.proquest.com/docview/47238708 https://www.proquest.com/docview/68376527 |
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