Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus
The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells...
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| Published in | Nature communications Vol. 11; no. 1; pp. 4063 - 16 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
13.08.2020
Nature Publishing Group Nature Portfolio |
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| Abstract | The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as
TTYH1
,
HMGA2
, and
FAM107A
. We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus.
The hypothalamus performs a wide range of vital physiological functions, including growth and reproductive behaviors, and circadian rhythms. The authors identify and characterize hypothalamic radial glial and hypothalamic mantle zone radial glial cells as the neural progenitors in the hypothalamus. |
|---|---|
| AbstractList | The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as TTYH1, HMGA2, and FAM107A. We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus.The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as TTYH1, HMGA2, and FAM107A. We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus. The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as TTYH1 , HMGA2 , and FAM107A . We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus. The hypothalamus performs a wide range of vital physiological functions, including growth and reproductive behaviors, and circadian rhythms. The authors identify and characterize hypothalamic radial glial and hypothalamic mantle zone radial glial cells as the neural progenitors in the hypothalamus. The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as TTYH1, HMGA2, and FAM107A. We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus. The hypothalamus performs a wide range of vital physiological functions, including growth and reproductive behaviors, and circadian rhythms. The authors identify and characterize hypothalamic radial glial and hypothalamic mantle zone radial glial cells as the neural progenitors in the hypothalamus. The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as TTYH1 , HMGA2 , and FAM107A . We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus. The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of hypothalamic neural progenitors remain unexplored. Here, hypothalamic radial glial (hRG) and hypothalamic mantle zone radial glial (hmRG) cells are found to be neural progenitors in the developing mammalian hypothalamus. The hmRG cells originate from hRG cells and produce neurons. During the early development of hypothalamus, neurogenesis occurs in radial columns and is initiated from hRG cells. The radial glial fibers are oriented toward the locations of hypothalamic subregions which act as a scaffold for neuronal migration. Furthermore, we use single-cell RNA sequencing to reveal progenitor subtypes in human developing hypothalamus and characterize specific progenitor genes, such as TTYH1, HMGA2, and FAM107A. We also demonstrate that HMGA2 is involved in E2F1 pathway, regulating the proliferation of progenitor cells by targeting on the downstream MYBL2. Different neuronal subtypes start to differentiate and express specific genes of hypothalamic nucleus at gestational week 10. Finally, we reveal the developmental conservation of nuclear structures and marker genes in mouse and human hypothalamus. Our identification of cellular and molecular properties of neural progenitors provides a basic understanding of neurogenesis and regional formation of the non-laminated hypothalamus.The hypothalamus performs a wide range of vital physiological functions, including growth and reproductive behaviors, and circadian rhythms. The authors identify and characterize hypothalamic radial glial and hypothalamic mantle zone radial glial cells as the neural progenitors in the hypothalamus. |
| ArticleNumber | 4063 |
| Author | Ma, Qiang Liu, Zeyuan Liu, Jing Peng, Honghai Sun, Le Wang, Xiaoqun Zhou, Xin Wu, Qian Zhong, Suijuan Ding, Wenyu Chen, Ruiguo |
| Author_xml | – sequence: 1 givenname: Xin surname: Zhou fullname: Zhou, Xin organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences – sequence: 2 givenname: Suijuan surname: Zhong fullname: Zhong, Suijuan organization: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, IDG/McGovern Institute for Brain Research, Beijing Normal University – sequence: 3 givenname: Honghai surname: Peng fullname: Peng, Honghai organization: Department of Neurosurgery, Jinan Central Hospital Affiliated to Shandong University – sequence: 4 givenname: Jing surname: Liu fullname: Liu, Jing organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences – sequence: 5 givenname: Wenyu surname: Ding fullname: Ding, Wenyu organization: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, IDG/McGovern Institute for Brain Research, Beijing Normal University – sequence: 6 givenname: Le surname: Sun fullname: Sun, Le organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences – sequence: 7 givenname: Qiang surname: Ma fullname: Ma, Qiang organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences – sequence: 8 givenname: Zeyuan surname: Liu fullname: Liu, Zeyuan organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences – sequence: 9 givenname: Ruiguo orcidid: 0000-0003-3564-9937 surname: Chen fullname: Chen, Ruiguo organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences – sequence: 10 givenname: Qian orcidid: 0000-0002-7469-1583 surname: Wu fullname: Wu, Qian organization: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, IDG/McGovern Institute for Brain Research, Beijing Normal University – sequence: 11 givenname: Xiaoqun orcidid: 0000-0003-3440-2617 surname: Wang fullname: Wang, Xiaoqun email: xiaoqunwang@ibp.ac.cn organization: State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Brain-Intelligence Technology (Shanghai), Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Advanced Innovation Center for Human Brain Protection, Beijing Institute for Brain Disorders, Capital Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32792525$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0092-8674(95)90035-7 10.1038/s41593-019-0349-8 10.1016/0014-4886(73)90187-8 10.1111/j.1365-2826.2005.01293.x 10.1016/j.yfrne.2006.02.002 10.1038/s41467-019-11667-y 10.1126/science.aau5324 10.1016/j.cell.2007.04.041 10.1016/0006-8993(71)90119-3 10.1002/cne.901930316 10.1093/cercor/13.6.550 10.1016/0165-3806(94)90134-1 10.1016/B978-0-12-416021-7.00002-X 10.1073/pnas.1500672112 10.1007/978-3-642-71301-9_1 10.3389/fnana.2015.00047 10.1038/nn.2545 10.1002/wdev.187 10.1016/j.cell.2005.02.012 10.1016/S0896-6273(01)00420-2 10.1097/MPG.0b013e3181977375 10.1038/nature08845 10.1038/nbt.4314 10.1242/dev.139055 10.1016/j.neuroscience.2012.09.006 10.1128/MCB.21.14.4684-4699.2001 10.1002/cne.901440204 10.1016/j.celrep.2017.03.004 10.1038/nn1172 10.1016/j.neuron.2015.03.022 10.1038/nn.2807 10.1186/1471-2105-9-559 10.1016/j.cub.2014.10.023 10.1038/ncomms2647 10.1038/nrm1739 10.1186/1749-8104-7-4 10.1371/journal.pbio.3000705 10.1016/j.molmet.2016.06.004 10.1016/S0896-6273(04)00140-0 10.1016/j.neuron.2013.02.018 10.1038/35055553 10.1038/35106593 10.1002/neu.480260107 10.1038/nn.4462 10.3390/s101009002 10.1523/JNEUROSCI.2899-04.2005 10.1002/neu.10011 10.1016/j.cell.2015.09.004 10.1371/journal.pbio.3000172 10.1038/nbt.3192 10.1002/(SICI)1097-0177(199608)206:4<455::AID-AJA11>3.0.CO;2-W 10.1038/s41593-020-0586-x 10.1016/j.stem.2017.08.013 10.1038/nn.4495 10.1523/JNEUROSCI.4773-10.2011 10.1016/j.cell.2019.09.020 10.1007/978-3-319-63260-5_4 10.1007/s12035-015-9367-z 10.1242/dev.120154 10.1016/j.cell.2011.06.030 10.1002/cne.10293 10.1016/j.cub.2016.11.008 10.1210/endo.143.2.8652 10.1016/j.tem.2013.10.005 10.1016/j.ydbio.2006.06.019 10.1002/cphy.c150023 10.1034/j.1399-0004.2001.600402.x 10.1016/B978-0-12-369497-3.10008-1 |
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| References | Gotz, Huttner (CR48) 2005; 6 Miyata, Kawaguchi, Okano, Ogawa (CR47) 2001; 31 Michaud (CR10) 2001; 60 Levitt, Rakic (CR49) 1980; 193 Kim (CR61) 2019; 179 Kimura, Matsunami, Takeichi (CR55) 1996; 206 Ishida (CR63) 2001; 21 Biran, Tahor, Wircer, Levkowitz (CR39) 2015; 9 Wang, Tsai, LaMonica, Kriegstein (CR25) 2011; 14 Wen (CR60) 2020; 23 Sokolowski (CR18) 2015; 86 Saper, Lowell (CR4) 2014; 24 Mungenast, Ojeda (CR56) 2005; 17 Sousa-Ferreira, Almeida, Cavadas (CR14) 2014; 25 Dellovade (CR58) 2001; 49 Anthony, Klein, Fishell, Heintz (CR27) 2004; 41 Satija, Farrell, Gennert, Schier, Regev (CR34) 2015; 33 Altman, Bayer (CR45) 1986; 100 Naganuma (CR17) 2019; 17 Zong, Espinosa, Su, Muzumdar, Luo (CR33) 2005; 121 Wu (CR62) 2001; 414 Becht (CR35) 2019; 37 Langfelder, Horvath (CR37) 2008; 9 CR44 Alayne Pearson, Placzek (CR8) 2013; 106 Routh (CR12) 2010; 10 Englund (CR30) 2005; 25 Bouret (CR67) 2009; 48 Tessmar-Raible (CR6) 2007; 129 Shimada, Nakamura (CR46) 1973; 41 Pollen (CR36) 2015; 163 Caqueret, Yang, Duplan, Boucher, Michaud (CR9) 2005; 64 Davis, Henion, Tobet (CR59) 2002; 449 Liu (CR68) 2017; 21 Noctor, Martinez-Cerdeno, Ivic, Kriegstein (CR29) 2004; 7 Tobet, Paredes, Chickering, Baum (CR54) 1995; 26 Ifft (CR64) 1972; 144 Romanov (CR22) 2017; 20 Burbridge, Stewart, Placzek (CR2) 2016; 6 Nasif (CR16) 2015; 112 Shimogori (CR65) 2010; 13 McClellan, Parker, Tobet (CR40) 2006; 27 Lui, Hansen, Kriegstein (CR52) 2011; 146 Asahina, Masuba, Hirano, Yuri (CR57) 2012; 225 Campbell (CR20) 2017; 20 Bedont, Newman, Blackshaw (CR3) 2015; 4 Mickelsen (CR24) 2019; 22 Chenn, McConnell (CR31) 1995; 82 Shitamukai, Konno, Matsuzaki (CR50) 2011; 31 Gao, Sun (CR38) 2016; 53 Carmo-Silva, Cavadas (CR11) 2017; 19 Majdic (CR41) 2002; 143 van Eerdenburg, Rakic (CR66) 1994; 79 Bedont (CR19) 2017; 27 Caqueret, Boucher, Michaud (CR42) 2006; 298 Rakic (CR53) 1971; 33 Huisman (CR43) 2019; 10 Noctor, Flint, Weissman, Dammerman, Kriegstein (CR28) 2001; 409 LaMonica, Lui, Hansen, Kriegstein (CR32) 2013; 4 Shi (CR69) 2020; 18 Chen, Wu, Jiang, Zhang (CR21) 2017; 18 Weissman, Noctor, Clinton, Honig, Kriegstein (CR51) 2003; 13 Sohn (CR13) 2016; 5 Lee, Lee, Lee, Lee (CR15) 2016; 143 Sternson (CR7) 2013; 77 Alvarez-Bolado, Paul, Blaess (CR5) 2012; 7 Xie, Dorsky (CR1) 2017; 144 Moffitt (CR23) 2018; 362 Hansen, Lui, Parker, Kriegstein (CR26) 2010; 464 SM Sternson (17890_CR7) 2013; 77 C Englund (17890_CR30) 2005; 25 S Burbridge (17890_CR2) 2016; 6 G Alvarez-Bolado (17890_CR5) 2012; 7 A Caqueret (17890_CR9) 2005; 64 RA Romanov (17890_CR22) 2017; 20 G Majdic (17890_CR41) 2002; 143 K Sokolowski (17890_CR18) 2015; 86 J Altman (17890_CR45) 1986; 100 M Shimada (17890_CR46) 1973; 41 S Nasif (17890_CR16) 2015; 112 Y Xie (17890_CR1) 2017; 144 TL Dellovade (17890_CR58) 2001; 49 JH Lui (17890_CR52) 2011; 146 J Liu (17890_CR68) 2017; 21 Y Gao (17890_CR38) 2016; 53 P Rakic (17890_CR53) 1971; 33 B Lee (17890_CR15) 2016; 143 T Miyata (17890_CR47) 2001; 31 JL Bedont (17890_CR3) 2015; 4 BE LaMonica (17890_CR32) 2013; 4 H Zong (17890_CR33) 2005; 121 L Wu (17890_CR62) 2001; 414 SC Noctor (17890_CR29) 2004; 7 J-W Sohn (17890_CR13) 2016; 5 JD Ifft (17890_CR64) 1972; 144 TE Anthony (17890_CR27) 2004; 41 JL Bedont (17890_CR19) 2017; 27 X Wang (17890_CR25) 2011; 14 S Wen (17890_CR60) 2020; 23 S Ishida (17890_CR63) 2001; 21 VH Routh (17890_CR12) 2010; 10 SC Noctor (17890_CR28) 2001; 409 A Shitamukai (17890_CR50) 2011; 31 DV Hansen (17890_CR26) 2010; 464 E Becht (17890_CR35) 2019; 37 CB Saper (17890_CR4) 2014; 24 SG Bouret (17890_CR67) 2009; 48 T Weissman (17890_CR51) 2003; 13 AA Pollen (17890_CR36) 2015; 163 R Chen (17890_CR21) 2017; 18 P Langfelder (17890_CR37) 2008; 9 A Caqueret (17890_CR42) 2006; 298 C Alayne Pearson (17890_CR8) 2013; 106 J Biran (17890_CR39) 2015; 9 17890_CR44 KM McClellan (17890_CR40) 2006; 27 T Shimogori (17890_CR65) 2010; 13 M Gotz (17890_CR48) 2005; 6 AM Davis (17890_CR59) 2002; 449 R Satija (17890_CR34) 2015; 33 K Tessmar-Raible (17890_CR6) 2007; 129 AE Mungenast (17890_CR56) 2005; 17 P Levitt (17890_CR49) 1980; 193 S Carmo-Silva (17890_CR11) 2017; 19 JR Moffitt (17890_CR23) 2018; 362 JL Michaud (17890_CR10) 2001; 60 JN Campbell (17890_CR20) 2017; 20 F Naganuma (17890_CR17) 2019; 17 LE Mickelsen (17890_CR24) 2019; 22 A Chenn (17890_CR31) 1995; 82 SA Tobet (17890_CR54) 1995; 26 FJ van Eerdenburg (17890_CR66) 1994; 79 D-W Kim (17890_CR61) 2019; 179 L Sousa-Ferreira (17890_CR14) 2014; 25 Y Kimura (17890_CR55) 1996; 206 C Huisman (17890_CR43) 2019; 10 H Asahina (17890_CR57) 2012; 225 Y Shi (17890_CR69) 2020; 18 |
| References_xml | – volume: 82 start-page: 631 year: 1995 end-page: 641 ident: CR31 article-title: Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesis publication-title: Cell doi: 10.1016/0092-8674(95)90035-7 – volume: 22 start-page: 642 year: 2019 end-page: 656 ident: CR24 article-title: Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons publication-title: Nat. Neurosci. doi: 10.1038/s41593-019-0349-8 – volume: 41 start-page: 163 year: 1973 end-page: 173 ident: CR46 article-title: Time of neuron origin in mouse hypothalamic nuclei publication-title: Exp. Neurol. doi: 10.1016/0014-4886(73)90187-8 – volume: 17 start-page: 208 year: 2005 end-page: 219 ident: CR56 article-title: Expression of three gene families encoding cell-cell communication molecules in the prepubertal nonhuman primate hypothalamus publication-title: J. Neuroendocrinol. doi: 10.1111/j.1365-2826.2005.01293.x – volume: 27 start-page: 193 year: 2006 end-page: 209 ident: CR40 article-title: Development of the ventromedial nucleus of the hypothalamus publication-title: Front. Neuroendocrinol. doi: 10.1016/j.yfrne.2006.02.002 – volume: 10 year: 2019 ident: CR43 article-title: Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators publication-title: Nat. Commun. doi: 10.1038/s41467-019-11667-y – volume: 362 start-page: eaau5324 year: 2018 ident: CR23 article-title: Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region publication-title: Science doi: 10.1126/science.aau5324 – volume: 129 start-page: 1389 year: 2007 end-page: 1400 ident: CR6 article-title: Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution publication-title: Cell doi: 10.1016/j.cell.2007.04.041 – volume: 33 start-page: 471 year: 1971 end-page: 476 ident: CR53 article-title: Guidance of neurons migrating to the fetal monkey neocortex publication-title: Brain Res. doi: 10.1016/0006-8993(71)90119-3 – volume: 193 start-page: 815 year: 1980 end-page: 840 ident: CR49 article-title: Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain publication-title: J. Comp. Neurol. doi: 10.1002/cne.901930316 – volume: 64 start-page: 222 year: 2005 end-page: 230 ident: CR9 article-title: Looking for trouble: a search for developmental defects of the hypothalamus publication-title: Horm. Res. – volume: 13 start-page: 550 year: 2003 end-page: 559 ident: CR51 article-title: Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration publication-title: Cereb. Cortex doi: 10.1093/cercor/13.6.550 – volume: 79 start-page: 290 year: 1994 end-page: 296 ident: CR66 article-title: Early neurogenesis in the anterior hypothalamus of the rhesus monkey publication-title: Brain Res. Dev. Brain Res. doi: 10.1016/0165-3806(94)90134-1 – volume: 106 start-page: 49 year: 2013 end-page: 88 ident: CR8 article-title: Development of the medial hypothalamus: forming a functional hypothalamic-neurohypophyseal interface publication-title: Curr. Top. Dev. Biol. doi: 10.1016/B978-0-12-416021-7.00002-X – volume: 112 start-page: E1861 year: 2015 end-page: E1870 ident: CR16 article-title: Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1500672112 – volume: 100 start-page: 1 year: 1986 end-page: 178 ident: CR45 article-title: The development of the rat hypothalamus publication-title: Adv. Anat. Embryol. Cell Biol. doi: 10.1007/978-3-642-71301-9_1 – volume: 9 start-page: 47 year: 2015 ident: CR39 article-title: Role of developmental factors in hypothalamic function publication-title: Front. Neuroanat. doi: 10.3389/fnana.2015.00047 – volume: 13 start-page: 767 year: 2010 end-page: 775 ident: CR65 article-title: A genomic atlas of mouse hypothalamic development publication-title: Nat. Neurosci. doi: 10.1038/nn.2545 – volume: 4 start-page: 445 year: 2015 end-page: 468 ident: CR3 article-title: Patterning, specification, and differentiation in the developing hypothalamus publication-title: Wiley Interdiscip. Rev. Dev. Biol. doi: 10.1002/wdev.187 – volume: 121 start-page: 479 year: 2005 end-page: 492 ident: CR33 article-title: Mosaic analysis with double markers in mice publication-title: Cell doi: 10.1016/j.cell.2005.02.012 – volume: 31 start-page: 727 year: 2001 end-page: 741 ident: CR47 article-title: Asymmetric inheritance of radial glial fibers by cortical neurons publication-title: Neuron doi: 10.1016/S0896-6273(01)00420-2 – volume: 48 start-page: S31 issue: Suppl 1 year: 2009 end-page: S38 ident: CR67 article-title: Early life origins of obesity: role of hypothalamic programming publication-title: J. Pediatr. Gastroenterol. Nutr. doi: 10.1097/MPG.0b013e3181977375 – volume: 464 start-page: 554 year: 2010 end-page: 561 ident: CR26 article-title: Neurogenic radial glia in the outer subventricular zone of human neocortex publication-title: Nature doi: 10.1038/nature08845 – volume: 37 start-page: 38 year: 2019 end-page: 44 ident: CR35 article-title: Dimensionality reduction for visualizing single-cell data using UMAP publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4314 – volume: 144 start-page: 1588 year: 2017 end-page: 1599 ident: CR1 article-title: Development of the hypothalamus: conservation, modification and innovation publication-title: Development doi: 10.1242/dev.139055 – volume: 225 start-page: 88 year: 2012 end-page: 104 ident: CR57 article-title: Distribution of protocadherin 9 protein in the developing mouse nervous system publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.09.006 – volume: 21 start-page: 4684 year: 2001 ident: CR63 article-title: Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.14.4684-4699.2001 – volume: 144 start-page: 193 year: 1972 end-page: 204 ident: CR64 article-title: An autoradiographic study of the time of final division of neurons in rat hypothalamic nuclei publication-title: J. Comp. Neurol. doi: 10.1002/cne.901440204 – volume: 18 start-page: 3227 year: 2017 end-page: 3241 ident: CR21 article-title: Single-cell RNA-seq reveals hypothalamic cell diversity publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.03.004 – volume: 7 start-page: 136 year: 2004 end-page: 144 ident: CR29 article-title: Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases publication-title: Nat. Neurosci. doi: 10.1038/nn1172 – volume: 86 start-page: 403 year: 2015 end-page: 416 ident: CR18 article-title: Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene Dbx1 publication-title: Neuron doi: 10.1016/j.neuron.2015.03.022 – volume: 14 start-page: 555 year: 2011 end-page: 561 ident: CR25 article-title: A new subtype of progenitor cell in the mouse embryonic neocortex publication-title: Nat. Neurosci. doi: 10.1038/nn.2807 – volume: 9 start-page: 559 year: 2008 end-page: 559 ident: CR37 article-title: WGCNA: an R package for weighted correlation network analysis publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-9-559 – volume: 24 start-page: R1111 year: 2014 end-page: R1116 ident: CR4 article-title: The hypothalamus publication-title: Curr. Biol. doi: 10.1016/j.cub.2014.10.023 – volume: 4 year: 2013 ident: CR32 article-title: Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex publication-title: Nat. Commun. doi: 10.1038/ncomms2647 – volume: 6 start-page: 777 year: 2005 end-page: 788 ident: CR48 article-title: The cell biology of neurogenesis publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1739 – volume: 7 start-page: 4 year: 2012 ident: CR5 article-title: Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions publication-title: Neural Dev. doi: 10.1186/1749-8104-7-4 – volume: 18 start-page: e3000705 year: 2020 ident: CR69 article-title: Vascularized human cortical organoids (vOrganoids) model cortical development in vivo publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000705 – volume: 5 start-page: 669 year: 2016 end-page: 679 ident: CR13 article-title: Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons publication-title: Mol. Metab. doi: 10.1016/j.molmet.2016.06.004 – volume: 41 start-page: 881 year: 2004 end-page: 890 ident: CR27 article-title: Radial glia serve as neuronal progenitors in all regions of the central nervous system publication-title: Neuron doi: 10.1016/S0896-6273(04)00140-0 – volume: 77 start-page: 810 year: 2013 end-page: 824 ident: CR7 article-title: Hypothalamic survival circuits: blueprints for purposive behaviors publication-title: Neuron doi: 10.1016/j.neuron.2013.02.018 – volume: 409 start-page: 714 year: 2001 ident: CR28 article-title: Neurons derived from radial glial cells establish radial units in neocortex publication-title: Nature doi: 10.1038/35055553 – volume: 414 start-page: 457 year: 2001 end-page: 462 ident: CR62 article-title: The E2F1–3 transcription factors are essential for cellular proliferation publication-title: Nature doi: 10.1038/35106593 – volume: 26 start-page: 75 year: 1995 end-page: 86 ident: CR54 article-title: Telencephalic and diencephalic origin of radial glial processes in the developing preoptic area/anterior hypothalamus publication-title: J. Neurobiol. doi: 10.1002/neu.480260107 – volume: 20 start-page: 176 year: 2017 end-page: 188 ident: CR22 article-title: Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes publication-title: Nat. Neurosci. doi: 10.1038/nn.4462 – volume: 10 start-page: 9002 year: 2010 end-page: 9025 ident: CR12 article-title: Glucose sensing neurons in the ventromedial hypothalamus publication-title: Sensors (Basel) doi: 10.3390/s101009002 – volume: 25 start-page: 247 year: 2005 end-page: 251 ident: CR30 article-title: Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2899-04.2005 – volume: 49 start-page: 264 year: 2001 end-page: 276 ident: CR58 article-title: GABA influences the development of the ventromedial nucleus of the hypothalamus publication-title: J. Neurobiol. doi: 10.1002/neu.10011 – volume: 163 start-page: 55 year: 2015 end-page: 67 ident: CR36 article-title: Molecular identity of human outer radial glia during cortical development publication-title: Cell doi: 10.1016/j.cell.2015.09.004 – volume: 17 start-page: e3000172 year: 2019 ident: CR17 article-title: Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000172 – volume: 33 start-page: 495 year: 2015 ident: CR34 article-title: Spatial reconstruction of single-cell gene expression data publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3192 – volume: 206 start-page: 455 year: 1996 end-page: 462 ident: CR55 article-title: Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain publication-title: Dev. Dyn. doi: 10.1002/(SICI)1097-0177(199608)206:4<455::AID-AJA11>3.0.CO;2-W – volume: 23 start-page: 456 year: 2020 end-page: 467 ident: CR60 article-title: Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus publication-title: Nat. Neurosci. doi: 10.1038/s41593-020-0586-x – volume: 21 start-page: 635 year: 2017 end-page: 649 ident: CR68 article-title: The primate-specific gene TMEM14B marks outer radial glia cells and promotes cortical expansion and folding publication-title: Cell Stem Cell doi: 10.1016/j.stem.2017.08.013 – volume: 20 start-page: 484 year: 2017 end-page: 496 ident: CR20 article-title: A molecular census of arcuate hypothalamus and median eminence cell types publication-title: Nat. Neurosci. doi: 10.1038/nn.4495 – ident: CR44 – volume: 31 start-page: 3683 year: 2011 end-page: 3695 ident: CR50 article-title: Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer subventricular zone progenitors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4773-10.2011 – volume: 179 start-page: 713 year: 2019 end-page: 728 ident: CR61 article-title: Multimodal analysis of cell types in a hypothalamic node controlling social behavior publication-title: Cell doi: 10.1016/j.cell.2019.09.020 – volume: 19 start-page: 73 year: 2017 end-page: 116 ident: CR11 article-title: Hypothalamic dysfunction in obesity and metabolic disorders publication-title: Adv. Neurobiol. doi: 10.1007/978-3-319-63260-5_4 – volume: 53 start-page: 4275 year: 2016 end-page: 4285 ident: CR38 article-title: Molecular regulation of hypothalamic development and physiological functions publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9367-z – volume: 143 start-page: 3763 year: 2016 end-page: 3773 ident: CR15 article-title: The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons publication-title: Development doi: 10.1242/dev.120154 – volume: 146 start-page: 18 year: 2011 end-page: 36 ident: CR52 article-title: Development and evolution of the human neocortex publication-title: Cell doi: 10.1016/j.cell.2011.06.030 – volume: 449 start-page: 270 year: 2002 end-page: 280 ident: CR59 article-title: Gamma-aminobutyric acidB receptors and the development of the ventromedial nucleus of the hypothalamus publication-title: J. Comp. Neurol. doi: 10.1002/cne.10293 – volume: 27 start-page: 128 year: 2017 end-page: 136 ident: CR19 article-title: An LHX1-regulated transcriptional network controls sleep/wake coupling and thermal resistance of the central circadian clockworks publication-title: Curr. Biol. doi: 10.1016/j.cub.2016.11.008 – volume: 143 start-page: 607 year: 2002 end-page: 614 ident: CR41 article-title: Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity publication-title: Endocrinology doi: 10.1210/endo.143.2.8652 – volume: 25 start-page: 80 year: 2014 end-page: 88 ident: CR14 article-title: Role of hypothalamic neurogenesis in feeding regulation publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2013.10.005 – volume: 298 start-page: 95 year: 2006 end-page: 106 ident: CR42 article-title: Laminar organization of the early developing anterior hypothalamus publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2006.06.019 – volume: 6 start-page: 623 year: 2016 end-page: 643 ident: CR2 article-title: Development of the neuroendocrine hypothalamus publication-title: Compr. Physiol. doi: 10.1002/cphy.c150023 – volume: 60 start-page: 255 year: 2001 end-page: 263 ident: CR10 article-title: The developmental program of the hypothalamus and its disorders publication-title: Clin. Genet. doi: 10.1034/j.1399-0004.2001.600402.x – volume: 409 start-page: 714 year: 2001 ident: 17890_CR28 publication-title: Nature doi: 10.1038/35055553 – volume: 193 start-page: 815 year: 1980 ident: 17890_CR49 publication-title: J. Comp. Neurol. doi: 10.1002/cne.901930316 – volume: 163 start-page: 55 year: 2015 ident: 17890_CR36 publication-title: Cell doi: 10.1016/j.cell.2015.09.004 – volume: 53 start-page: 4275 year: 2016 ident: 17890_CR38 publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9367-z – volume: 414 start-page: 457 year: 2001 ident: 17890_CR62 publication-title: Nature doi: 10.1038/35106593 – volume: 7 start-page: 4 year: 2012 ident: 17890_CR5 publication-title: Neural Dev. doi: 10.1186/1749-8104-7-4 – volume: 362 start-page: eaau5324 year: 2018 ident: 17890_CR23 publication-title: Science doi: 10.1126/science.aau5324 – volume: 144 start-page: 193 year: 1972 ident: 17890_CR64 publication-title: J. Comp. Neurol. doi: 10.1002/cne.901440204 – volume: 79 start-page: 290 year: 1994 ident: 17890_CR66 publication-title: Brain Res. Dev. Brain Res. doi: 10.1016/0165-3806(94)90134-1 – volume: 146 start-page: 18 year: 2011 ident: 17890_CR52 publication-title: Cell doi: 10.1016/j.cell.2011.06.030 – volume: 64 start-page: 222 year: 2005 ident: 17890_CR9 publication-title: Horm. Res. – volume: 25 start-page: 247 year: 2005 ident: 17890_CR30 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.2899-04.2005 – volume: 18 start-page: e3000705 year: 2020 ident: 17890_CR69 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000705 – volume: 31 start-page: 3683 year: 2011 ident: 17890_CR50 publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4773-10.2011 – volume: 13 start-page: 550 year: 2003 ident: 17890_CR51 publication-title: Cereb. Cortex doi: 10.1093/cercor/13.6.550 – volume: 49 start-page: 264 year: 2001 ident: 17890_CR58 publication-title: J. Neurobiol. doi: 10.1002/neu.10011 – volume: 449 start-page: 270 year: 2002 ident: 17890_CR59 publication-title: J. Comp. Neurol. doi: 10.1002/cne.10293 – volume: 21 start-page: 4684 year: 2001 ident: 17890_CR63 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.21.14.4684-4699.2001 – volume: 121 start-page: 479 year: 2005 ident: 17890_CR33 publication-title: Cell doi: 10.1016/j.cell.2005.02.012 – volume: 4 year: 2013 ident: 17890_CR32 publication-title: Nat. Commun. doi: 10.1038/ncomms2647 – volume: 14 start-page: 555 year: 2011 ident: 17890_CR25 publication-title: Nat. Neurosci. doi: 10.1038/nn.2807 – volume: 206 start-page: 455 year: 1996 ident: 17890_CR55 publication-title: Dev. Dyn. doi: 10.1002/(SICI)1097-0177(199608)206:4<455::AID-AJA11>3.0.CO;2-W – volume: 106 start-page: 49 year: 2013 ident: 17890_CR8 publication-title: Curr. Top. Dev. Biol. doi: 10.1016/B978-0-12-416021-7.00002-X – volume: 19 start-page: 73 year: 2017 ident: 17890_CR11 publication-title: Adv. Neurobiol. doi: 10.1007/978-3-319-63260-5_4 – volume: 464 start-page: 554 year: 2010 ident: 17890_CR26 publication-title: Nature doi: 10.1038/nature08845 – volume: 23 start-page: 456 year: 2020 ident: 17890_CR60 publication-title: Nat. Neurosci. doi: 10.1038/s41593-020-0586-x – volume: 10 start-page: 9002 year: 2010 ident: 17890_CR12 publication-title: Sensors (Basel) doi: 10.3390/s101009002 – volume: 82 start-page: 631 year: 1995 ident: 17890_CR31 publication-title: Cell doi: 10.1016/0092-8674(95)90035-7 – volume: 37 start-page: 38 year: 2019 ident: 17890_CR35 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.4314 – volume: 48 start-page: S31 issue: Suppl 1 year: 2009 ident: 17890_CR67 publication-title: J. Pediatr. Gastroenterol. Nutr. doi: 10.1097/MPG.0b013e3181977375 – volume: 86 start-page: 403 year: 2015 ident: 17890_CR18 publication-title: Neuron doi: 10.1016/j.neuron.2015.03.022 – volume: 100 start-page: 1 year: 1986 ident: 17890_CR45 publication-title: Adv. Anat. Embryol. Cell Biol. doi: 10.1007/978-3-642-71301-9_1 – volume: 33 start-page: 471 year: 1971 ident: 17890_CR53 publication-title: Brain Res. doi: 10.1016/0006-8993(71)90119-3 – volume: 18 start-page: 3227 year: 2017 ident: 17890_CR21 publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.03.004 – volume: 60 start-page: 255 year: 2001 ident: 17890_CR10 publication-title: Clin. Genet. doi: 10.1034/j.1399-0004.2001.600402.x – volume: 20 start-page: 484 year: 2017 ident: 17890_CR20 publication-title: Nat. Neurosci. doi: 10.1038/nn.4495 – volume: 17 start-page: 208 year: 2005 ident: 17890_CR56 publication-title: J. Neuroendocrinol. doi: 10.1111/j.1365-2826.2005.01293.x – volume: 5 start-page: 669 year: 2016 ident: 17890_CR13 publication-title: Mol. Metab. doi: 10.1016/j.molmet.2016.06.004 – volume: 31 start-page: 727 year: 2001 ident: 17890_CR47 publication-title: Neuron doi: 10.1016/S0896-6273(01)00420-2 – volume: 27 start-page: 128 year: 2017 ident: 17890_CR19 publication-title: Curr. Biol. doi: 10.1016/j.cub.2016.11.008 – volume: 129 start-page: 1389 year: 2007 ident: 17890_CR6 publication-title: Cell doi: 10.1016/j.cell.2007.04.041 – volume: 21 start-page: 635 year: 2017 ident: 17890_CR68 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2017.08.013 – volume: 6 start-page: 777 year: 2005 ident: 17890_CR48 publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm1739 – volume: 225 start-page: 88 year: 2012 ident: 17890_CR57 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2012.09.006 – volume: 77 start-page: 810 year: 2013 ident: 17890_CR7 publication-title: Neuron doi: 10.1016/j.neuron.2013.02.018 – volume: 298 start-page: 95 year: 2006 ident: 17890_CR42 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2006.06.019 – volume: 143 start-page: 607 year: 2002 ident: 17890_CR41 publication-title: Endocrinology doi: 10.1210/endo.143.2.8652 – volume: 41 start-page: 881 year: 2004 ident: 17890_CR27 publication-title: Neuron doi: 10.1016/S0896-6273(04)00140-0 – volume: 41 start-page: 163 year: 1973 ident: 17890_CR46 publication-title: Exp. Neurol. doi: 10.1016/0014-4886(73)90187-8 – volume: 179 start-page: 713 year: 2019 ident: 17890_CR61 publication-title: Cell doi: 10.1016/j.cell.2019.09.020 – volume: 6 start-page: 623 year: 2016 ident: 17890_CR2 publication-title: Compr. Physiol. doi: 10.1002/cphy.c150023 – volume: 33 start-page: 495 year: 2015 ident: 17890_CR34 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3192 – volume: 9 start-page: 559 year: 2008 ident: 17890_CR37 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-9-559 – volume: 144 start-page: 1588 year: 2017 ident: 17890_CR1 publication-title: Development doi: 10.1242/dev.139055 – volume: 27 start-page: 193 year: 2006 ident: 17890_CR40 publication-title: Front. Neuroendocrinol. doi: 10.1016/j.yfrne.2006.02.002 – volume: 22 start-page: 642 year: 2019 ident: 17890_CR24 publication-title: Nat. Neurosci. doi: 10.1038/s41593-019-0349-8 – volume: 25 start-page: 80 year: 2014 ident: 17890_CR14 publication-title: Trends Endocrinol. Metab. doi: 10.1016/j.tem.2013.10.005 – volume: 20 start-page: 176 year: 2017 ident: 17890_CR22 publication-title: Nat. Neurosci. doi: 10.1038/nn.4462 – ident: 17890_CR44 doi: 10.1016/B978-0-12-369497-3.10008-1 – volume: 9 start-page: 47 year: 2015 ident: 17890_CR39 publication-title: Front. Neuroanat. doi: 10.3389/fnana.2015.00047 – volume: 112 start-page: E1861 year: 2015 ident: 17890_CR16 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1500672112 – volume: 10 year: 2019 ident: 17890_CR43 publication-title: Nat. Commun. doi: 10.1038/s41467-019-11667-y – volume: 4 start-page: 445 year: 2015 ident: 17890_CR3 publication-title: Wiley Interdiscip. Rev. Dev. Biol. doi: 10.1002/wdev.187 – volume: 26 start-page: 75 year: 1995 ident: 17890_CR54 publication-title: J. Neurobiol. doi: 10.1002/neu.480260107 – volume: 143 start-page: 3763 year: 2016 ident: 17890_CR15 publication-title: Development doi: 10.1242/dev.120154 – volume: 7 start-page: 136 year: 2004 ident: 17890_CR29 publication-title: Nat. Neurosci. doi: 10.1038/nn1172 – volume: 13 start-page: 767 year: 2010 ident: 17890_CR65 publication-title: Nat. Neurosci. doi: 10.1038/nn.2545 – volume: 24 start-page: R1111 year: 2014 ident: 17890_CR4 publication-title: Curr. Biol. doi: 10.1016/j.cub.2014.10.023 – volume: 17 start-page: e3000172 year: 2019 ident: 17890_CR17 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.3000172 |
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| Snippet | The neuroendocrine hypothalamus is the central regulator of vital physiological homeostasis and behavior. However, the cellular and molecular properties of... The hypothalamus performs a wide range of vital physiological functions, including growth and reproductive behaviors, and circadian rhythms. The authors... |
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| Title | Cellular and molecular properties of neural progenitors in the developing mammalian hypothalamus |
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