Differential Cytotoxicity of Corticosteroids on Human Mesenchymal Stem Cells

• Published in: Clinical orthopaedics and related research Vol. 473; no. 3; pp. 1155 - 1164
• Main Authors: Wyles, Cody C., Houdek, Matthew T., Wyles, Saranya P., Wagner, Eric R., Behfar, Atta, Sierra, Rafael J.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.03.2015; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - toxicity; Adult; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - toxicity; Basic Research; Cell Survival - drug effects; Chondrocytes - drug effects; Conservative Orthopedics; Dose-Response Relationship, Drug; Female; Humans; Male; Medicine; Medicine & Public Health; Mesenchymal Stromal Cells - drug effects; Middle Aged; Orthopedics; Sports Medicine; Surgery; Surgical Orthopedics; Average Optical Density; Avascular Necrosis; Triamcinolone; Betamethasone; Triamcinolone Acetonide

Background Corticosteroids are a common, short-term, local antiinflammatory and analgesic for treating patients with musculoskeletal disorders. Studies have shown the deleterious effects of corticosteroids on chondrocytes, suggesting a potentiation of degenerative joint disease. Mesenchymal stem cel...