Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

• Published in: Nature communications Vol. 11; no. 1; pp. 6145 - 9
• Main Authors: Girardi, Enrico, Agrimi, Gennaro, Goldmann, Ulrich, Fiume, Giuseppe, Lindinger, Sabrina, Sedlyarov, Vitaly, Srndic, Ismet, Gürtl, Bettina, Agerer, Benedikt, Kartnig, Felix, Scarcia, Pasquale, Di Noia, Maria Antonietta, Liñeiro, Eva, Rebsamen, Manuele, Wiedmer, Tabea, Bergthaler, Andreas, Palmieri, Luigi, Superti-Furga, Giulio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/44; 45; 49; 631/443/319; 631/80/642/333; 631/80/642/333/1465; Biological Transport; CRISPR; Epistasis; Epistasis, Genetic; Genes; Genetics; Genomics; Homology; Humanities and Social Sciences; Humans; Imports; Localization; Metabolism; Metabolomics; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; multidisciplinary; NAD; NAD - metabolism; Oxidation-Reduction; Science; Science (multidisciplinary); Uncoupling Protein 1 - genetics; Uncoupling Protein 1 - metabolism; Yeast

About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...