DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

• Published in: Nature communications Vol. 8; no. 1; pp. 908 - 11
• Main Authors: Roost, Matthias S., Slieker, Roderick C., Bialecka, Monika, van Iperen, Liesbeth, Gomes Fernandes, Maria M., He, Nannan, Suchiman, H. Eka D., Szuhai, Karoly, Carlotti, Françoise, de Koning, Eelco J. P., Mummery, Christine L., Heijmans, Bastiaan T., Chuva de Sousa Lopes, Susana M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.10.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/136/2442; 631/337/176/1988; 631/532/2442; Animal models; Brain; Cell lines; Deoxyribonucleic acid; DNA; DNA methylation; Epigenetics; Fetuses; Gene expression; Gestation; Humanities and Social Sciences; multidisciplinary; Organs; Pluripotency; Science; Science (multidisciplinary); Stem cell transplantation; Stem cells

Determining cell identity and maturation status of differentiated pluripotent stem cells (PSCs) requires knowledge of the transcriptional and epigenetic trajectory of organs during development. Here, we generate a transcriptional and DNA methylation atlas covering 21 organs during human fetal develo...