Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish

• Published in: Scientific reports Vol. 11; no. 1; p. 8392
• Main Authors: Inoue, Masanori, Miyahara, Hiroaki, Shiraishi, Hiroshi, Shimizu, Nobuyuki, Tsumori, Mika, Kiyota, Kyoko, Maeda, Miwako, Umeda, Ryohei, Ishitani, Tohru, Hanada, Reiko, Ihara, Kenji, Hanada, Toshikatsu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4017; 692/420; 692/699; Anemia; Autophagy; Danio rerio; Drug development; Fertilization; Humanities and Social Sciences; Lethality; Leucine; Leucine-tRNA ligase; Liver; Liver diseases; Microencephaly; multidisciplinary; Neurological diseases; Phagocytosis; Rapamycin; Science; Science (multidisciplinary); Seizures; Survival; TOR protein; tRNA Leu

Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to sensitize the intracellular leucine concentration to the mammalian target of rapamycin complex 1 (mTORC1) activation. Biallelic mutation in the LARS gene causes infantile li...