Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters

• Published in: Nature communications Vol. 10; no. 1; pp. 4792 - 14
• Main Authors: Zhang, Kaixi, Du, Yu, Si, Zhangyong, Liu, Yang, Turvey, Michelle E., Raju, Cheerlavancha, Keogh, Damien, Ruan, Lin, Jothy, Subramanion L., Reghu, Sheethal, Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Mediavilla, José R., Kreiswirth, Barry N., Chi, Yonggui Robin, Ren, Jinghua, Tam, Kam C., Liu, Xue-Wei, Duan, Hongwei, Zhu, Yabin, Mu, Yuguang, Hammond, Paula T., Bazan, Guillermo C., Pethe, Kevin, Chan-Park, Mary B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.10.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 14/19; 140/131; 140/58; 147/135; 147/143; 3T3 Cells; 45/22; 45/77; 631/326/22; 631/326/41; 631/326/421; 639/638/455; 64; 64/60; Animals; Antibacterial activity; Antibiotics; Bacteria; Bacterial diseases; Bacterial infections; beta-Lactams - chemical synthesis; beta-Lactams - pharmacology; beta-Lactams - therapeutic use; Biocompatibility; Biofilms; Biofilms - drug effects; Daptomycin; Drug resistance; Drug Resistance, Multiple, Bacterial; Glucose; Glucose - chemical synthesis; Glucose - pharmacology; Glucose - therapeutic use; Humanities and Social Sciences; Humans; In Vitro Techniques; Infections; Lysine; Lysine - analogs & derivatives; Lysine - chemical synthesis; Lysine - pharmacology; Lysine - therapeutic use; Methicillin; Methicillin-Resistant Staphylococcus aureus - drug effects; Mice; Microbial Sensitivity Tests; multidisciplinary; Peptides; Polymerization; Replication; Ring opening polymerization; Science; Science (multidisciplinary); Staphylococcal Skin Infections - drug therapy; Staphylococcus aureus; Staphylococcus infections; Toxicity; Vancomycin

The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)- block -poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring...