Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters

The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)- block -poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring...

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Published inNature communications Vol. 10; no. 1; pp. 4792 - 14
Main Authors Zhang, Kaixi, Du, Yu, Si, Zhangyong, Liu, Yang, Turvey, Michelle E., Raju, Cheerlavancha, Keogh, Damien, Ruan, Lin, Jothy, Subramanion L., Reghu, Sheethal, Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Mediavilla, José R., Kreiswirth, Barry N., Chi, Yonggui Robin, Ren, Jinghua, Tam, Kam C., Liu, Xue-Wei, Duan, Hongwei, Zhu, Yabin, Mu, Yuguang, Hammond, Paula T., Bazan, Guillermo C., Pethe, Kevin, Chan-Park, Mary B.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 21.10.2019
Nature Publishing Group
Nature Portfolio
Subjects
13/106
14/19
140/131
140/58
147/135
147/143
3T3 Cells
45/22
45/77
631/326/22
631/326/41
631/326/421
639/638/455
64
64/60
Animals
Antibacterial activity
Antibiotics
Bacteria
Bacterial diseases
Bacterial infections
beta-Lactams - chemical synthesis
beta-Lactams - pharmacology
beta-Lactams - therapeutic use
Biocompatibility
Biofilms
Biofilms - drug effects
Daptomycin
Drug resistance
Drug Resistance, Multiple, Bacterial
Glucose
Glucose - chemical synthesis
Glucose - pharmacology
Glucose - therapeutic use
Humanities and Social Sciences
Humans
In Vitro Techniques
Infections
Lysine
Lysine - analogs & derivatives
Lysine - chemical synthesis
Lysine - pharmacology
Lysine - therapeutic use
Methicillin
Methicillin-Resistant Staphylococcus aureus - drug effects
Mice
Microbial Sensitivity Tests
multidisciplinary
Peptides
Polymerization
Replication
Ring opening polymerization
Science
Science (multidisciplinary)
Staphylococcal Skin Infections - drug therapy
Staphylococcus aureus
Staphylococcus infections
Toxicity
Vancomycin
Online AccessGet full text

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Abstract The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)- block -poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass. It is active towards community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. Its antibacterial activity is superior to that of vancomycin in MRSA mouse and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The copolymer displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope. Our results indicate that this class of non-toxic molecule, effective against different bacterial sub-populations, has promising potential for the treatment of S. aureus infections. The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus , including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.
AbstractList The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)-block-poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass. It is active towards community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. Its antibacterial activity is superior to that of vancomycin in MRSA mouse and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The copolymer displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope. Our results indicate that this class of non-toxic molecule, effective against different bacterial sub-populations, has promising potential for the treatment of S. aureus infections.
The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)- block -poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass. It is active towards community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. Its antibacterial activity is superior to that of vancomycin in MRSA mouse and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The copolymer displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope. Our results indicate that this class of non-toxic molecule, effective against different bacterial sub-populations, has promising potential for the treatment of S. aureus infections. The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus , including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.
The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an enantiomeric block co-beta-peptide, poly(amido-D-glucose)- block -poly(beta-L-lysine), with high yield and purity by one-shot one-pot anionic-ring opening (co)polymerization. The co-beta-peptide is bactericidal against methicillin-resistant Staphylococcus aureus (MRSA), including replicating, biofilm and persister bacterial cells, and also disperses biofilm biomass. It is active towards community-acquired and hospital-associated MRSA strains which are resistant to multiple drugs including vancomycin and daptomycin. Its antibacterial activity is superior to that of vancomycin in MRSA mouse and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The copolymer displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope. Our results indicate that this class of non-toxic molecule, effective against different bacterial sub-populations, has promising potential for the treatment of S. aureus infections.
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.
ArticleNumber 4792
Author Si, Zhangyong
De, Partha Pratim
Zhang, Kaixi
Tam, Kam C.
Marimuthu, Kalisvar
Hammond, Paula T.
Bazan, Guillermo C.
Chi, Yonggui Robin
Mediavilla, José R.
Pethe, Kevin
Kreiswirth, Barry N.
Ren, Jinghua
Liu, Xue-Wei
Jothy, Subramanion L.
Mu, Yuguang
Raju, Cheerlavancha
Keogh, Damien
Chan-Park, Mary B.
Liu, Yang
Ng, Oon Tek
Zhu, Yabin
Reghu, Sheethal
Du, Yu
Ruan, Lin
Duan, Hongwei
Turvey, Michelle E.
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  givenname: Yu
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  surname: Mediavilla
  fullname: Mediavilla, José R.
  organization: Center for Discovery and Innovation, Hackensack Meridian Health
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  organization: Cancer Center, Union Hospital, Huazhong University of Science & Technology
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  givenname: Paula T.
  orcidid: 0000-0002-9835-192X
  surname: Hammond
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  organization: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Department of Chemical Engineering, Massachusetts Institute of Technology
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  surname: Chan-Park
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  email: mbechan@ntu.edu.sg
  organization: School of Chemical and Biomedical Engineering, Nanyang Technological University, Centre for Antimicrobial Bioengineering, Nanyang Technological University, Lee Kong Chian School of Medicine, Nanyang Technological University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31636263$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1056/NEJMcp070747
10.1038/nature12790
10.1128/IAI.00616-09
10.1038/nrmicro3480
10.1093/cid/cix640
10.2147/DDDT.S72129
10.1038/nrmicro.2017.42
10.1021/jacs.6b01837
10.1021/acs.nanolett.8b01000
10.1016/j.cell.2014.02.050
10.1038/nrmicro.2017.99
10.1111/1574-6968.12424
10.1038/35007145
10.1021/ma970665u
10.1126/science.aaf4268
10.1021/bi049414l
10.1086/653519
10.1128/CMR.05022-11
10.1002/(SICI)1521-3773(19990601)38:11<1595::AID-ANIE1595>3.0.CO;2-0
10.1038/nrmicro3161
10.1126/science.aad3292
10.1021/ja901613g
10.1126/scitranslmed.aan4044
10.1371/journal.ppat.1005671
10.1021/ma00167a013
10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5
10.1016/j.chembiol.2015.10.005
10.1016/j.cis.2015.10.011
10.1021/cr000045i
10.1021/ja500036r
10.1016/S0140-6736(09)61999-1
10.1126/scitranslmed.3004528
10.1038/nature26157
10.1039/c3cs60384a
10.1038/nbt1309
10.1021/ja077288d
10.1038/nature14098
10.1021/ja500367u
10.1186/s12866-016-0737-0
10.1038/nrd3591
10.1046/j.1462-5822.2004.00367.x
10.1016/j.biomaterials.2006.11.046
10.4049/jimmunol.175.6.3810
10.1128/AAC.00427-13
10.1073/pnas.1420380112
10.1038/311053a0
10.1021/mp5004724
10.1128/AAC.00467-12
10.1021/ja0107475
10.1093/jac/dkn513
10.1021/ar700263g
10.1093/jac/47.5.647
10.1128/AAC.50.2.765-769.2006
10.1039/c2sc20428b
10.1038/nmicrobiol.2016.51
10.1021/acsnano.5b07515
10.1038/nrmicro2695
10.1042/BJ20141251
10.1016/j.bbamem.2008.09.013
10.1038/387381a0
10.1073/pnas.0708254105
10.1371/journal.pone.0017936
10.1111/j.1524-475X.2012.00836.x
10.1021/ja0459375
10.1093/femsre/fux007
10.1021/ja0260871
10.1007/978-3-319-09782-4_1
10.1159/000491497
10.1128/IAI.67.10.5427-5433.1999
10.1038/s41579-018-0019-y
10.1128/JB.00011-12
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References Harms, Maisonneuve, Gerdes (CR4) 2016; 354
Van Hal (CR13) 2012; 25
Rohde (CR60) 2007; 28
Cramton, Gerke, Schnell, Nichols, Götz (CR62) 1999; 67
Koo, Allan, Howlin, Stoodley, Hall-Stoodley (CR69) 2017; 15
Foster, Geoghegan, Ganesh, Höök (CR3) 2014; 12
Fisher, Gollan, Helaine (CR6) 2017; 15
Liu (CR46) 2014; 136
(CR8) 2017
Roche, Renick, Tetens, Carson (CR66) 2012; 56
CR76
Gopalan, Del Borgo, Mechler, Perlmutter, Aguilar (CR40) 2015; 22
Porter, Wang, Lee, Weisblum, Gellman (CR23) 2000; 404
DeLeo, Otto, Kreiswirth, Chambers (CR11) 2010; 375
Busscher (CR70) 2012; 4
CR5
Avan, Hall, Katritzky (CR21) 2014; 43
Appella (CR39) 1997; 387
Baym, Stone, Kishony (CR77) 2016; 351
Chin (CR52) 2016; 138
CR9
Kosowska-Shick (CR49) 2006; 50
Percival (CR65) 2012; 20
Conlon (CR2) 2016; 1
O’neill, Cove, Chopra (CR50) 2001; 47
Fernandez-Santin (CR43) 1987; 20
Seebach, Gardiner (CR32) 2008; 41
Dantes (CR12) 2013; 173
Epand, Raguse, Gellman, Epand (CR30) 2004; 43
Daum (CR14) 2007; 357
de Breij (CR19) 2018; 10
Maisonneuve, Gerdes (CR7) 2014; 157
Checco (CR33) 2015; 112
Segev-Zarko, Saar-Dover, Brumfeld, Mangoni, Shai (CR74) 2015; 468
O’Halloran, McCourt, Geoghegan, McCarthy, O’Gara (CR57) 2014; 353
Wu (CR24) 2012; 3
Kritzer (CR54) 2005; 127
Brown, Wolf, Prados-Rosales, Casadevall (CR55) 2015; 13
CR56
CR10
Li (CR75) 2018; 18
Ling (CR51) 2015; 517
Vergara-Irigaray (CR58) 2009; 77
Fjell, Hiss, Hancock, Schneider (CR36) 2011; 11
Seebach, Abele, Gademann, Jaun (CR38) 1999; 38
Conlon (CR64) 2013; 503
Mowery, Lindner, Weisblum, Stahl, Gellman (CR45) 2009; 131
García-Alvarez, León, Alemán, Campos, Muñoz-Guerra (CR42) 1998; 31
Klein (CR16) 2017; 65
McDougald, Rice, Barraud, Steinberg, Kjelleberg (CR73) 2012; 10
Formosa-Dague (CR59) 2016; 10
Nadithe (CR34) 2014; 12
Foster (CR1) 2017; 41
Fernandez-Santin, Aymamí, Rodríguez-Galán, Munoz-Guerra, Subirana (CR41) 1984; 311
Webb (CR31) 2005; 175
Abele, Guichard, Seebach (CR53) 1998; 81
Manaargadoo-Catin, Ali-Cherif, Pougnas, Perrin (CR68) 2016; 228
Mottola (CR71) 2016; 16
Rose, Poppens (CR17) 2008; 63
Kim (CR18) 2018; 556
Liu (CR47) 2014; 136
Seebach (CR26) 1998; 52
Sparr (CR35) 2013; 57
Monecke (CR48) 2011; 6
Vuong (CR61) 2004; 6
Boucher, Miller, Razonable (CR15) 2010; 51
Porter, Weisblum, Gellman (CR28) 2002; 124
Liu, DeGrado (CR29) 2001; 123
Mowery (CR44) 2007; 129
CR20
Hintermann, Seebach (CR27) 1997; 51
Cheng, Gellman, DeGrado (CR37) 2001; 101
Chongsiriwatana (CR22) 2008; 105
Radzishevsky (CR25) 2007; 25
Zapotoczna, O’Neill, O’Gara (CR63) 2016; 12
Matsuzaki (CR67) 2009; 1788
Mohamed, Seleem (CR72) 2014; 8
ED Roche (12702_CR66) 2012; 56
RP Cheng (12702_CR37) 2001; 101
S Abele (12702_CR53) 1998; 81
D Seebach (12702_CR26) 1998; 52
T Hintermann (12702_CR27) 1997; 51
CD Fjell (12702_CR36) 2011; 11
D McDougald (12702_CR73) 2012; 10
SE Cramton (12702_CR62) 1999; 67
12702_CR76
BP Conlon (12702_CR2) 2016; 1
NP Chongsiriwatana (12702_CR22) 2008; 105
M Manaargadoo-Catin (12702_CR68) 2016; 228
LL Ling (12702_CR51) 2015; 517
FR DeLeo (12702_CR11) 2010; 375
A de Breij (12702_CR19) 2018; 10
JW Checco (12702_CR33) 2015; 112
R Dantes (12702_CR12) 2013; 173
EA Porter (12702_CR28) 2002; 124
DP O’Halloran (12702_CR57) 2014; 353
J Fernandez-Santin (12702_CR41) 1984; 311
DH Appella (12702_CR39) 1997; 387
J Fernandez-Santin (12702_CR43) 1987; 20
W Kim (12702_CR18) 2018; 556
H Rohde (12702_CR60) 2007; 28
S Monecke (12702_CR48) 2011; 6
M García-Alvarez (12702_CR42) 1998; 31
EY Klein (12702_CR16) 2017; 65
SL Percival (12702_CR65) 2012; 20
R Liu (12702_CR47) 2014; 136
SJ Van Hal (12702_CR13) 2012; 25
SL Chin (12702_CR52) 2016; 138
TJ Foster (12702_CR1) 2017; 41
12702_CR20
RS Daum (12702_CR14) 2007; 357
RF Epand (12702_CR30) 2004; 43
Organization, W. H. (12702_CR8) 2017
L-a Segev-Zarko (12702_CR74) 2015; 468
J Li (12702_CR75) 2018; 18
B Conlon (12702_CR64) 2013; 503
E Maisonneuve (12702_CR7) 2014; 157
H Koo (12702_CR69) 2017; 15
C Mottola (12702_CR71) 2016; 16
12702_CR9
R Liu (12702_CR46) 2014; 136
K Kosowska-Shick (12702_CR49) 2006; 50
WE Rose (12702_CR17) 2008; 63
I Avan (12702_CR21) 2014; 43
K Matsuzaki (12702_CR67) 2009; 1788
12702_CR10
M Vergara-Irigaray (12702_CR58) 2009; 77
BP Mowery (12702_CR45) 2009; 131
12702_CR56
L Brown (12702_CR55) 2015; 13
EA Porter (12702_CR23) 2000; 404
D Seebach (12702_CR38) 1999; 38
MF Mohamed (12702_CR72) 2014; 8
M Baym (12702_CR77) 2016; 351
D Liu (12702_CR29) 2001; 123
A Harms (12702_CR4) 2016; 354
C Vuong (12702_CR61) 2004; 6
RA Fisher (12702_CR6) 2017; 15
C Formosa-Dague (12702_CR59) 2016; 10
H Boucher (12702_CR15) 2010; 51
M Zapotoczna (12702_CR63) 2016; 12
JA Kritzer (12702_CR54) 2005; 127
TJ Foster (12702_CR3) 2014; 12
AI Webb (12702_CR31) 2005; 175
BP Mowery (12702_CR44) 2007; 129
AJ O’neill (12702_CR50) 2001; 47
H Wu (12702_CR24) 2012; 3
C Sparr (12702_CR35) 2013; 57
HJ Busscher (12702_CR70) 2012; 4
IS Radzishevsky (12702_CR25) 2007; 25
D Seebach (12702_CR32) 2008; 41
V Nadithe (12702_CR34) 2014; 12
RD Gopalan (12702_CR40) 2015; 22
12702_CR5
References_xml – volume: 357
  start-page: 380
  year: 2007
  end-page: 390
  ident: CR14
  article-title: Skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus
  publication-title: New Engl. J. Med.
  doi: 10.1056/NEJMcp070747
  contributor:
    fullname: Daum
– volume: 503
  start-page: 365
  year: 2013
  ident: CR64
  article-title: Killing persister cells and eradicating a biofilm infection by activating the ClpP protease
  publication-title: Nature
  doi: 10.1038/nature12790
  contributor:
    fullname: Conlon
– volume: 77
  start-page: 3978
  year: 2009
  end-page: 3991
  ident: CR58
  article-title: Relevant role of fibronectin-binding proteins in staphylococcus aureus biofilm-associated foreign-body infections
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00616-09
  contributor:
    fullname: Vergara-Irigaray
– volume: 52
  start-page: 734
  year: 1998
  end-page: 739
  ident: CR26
  article-title: Biological and pharmacokinetic studies with β-peptides. CHIMIA International
  publication-title: J. Chem.
  contributor:
    fullname: Seebach
– volume: 13
  start-page: 620
  year: 2015
  ident: CR55
  article-title: Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro3480
  contributor:
    fullname: Casadevall
– volume: 65
  start-page: 1921
  year: 2017
  end-page: 1923
  ident: CR16
  article-title: Trends in methicillin-resistant Staphylococcus aureus hospitalizations in the United States, 2010-2014
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix640
  contributor:
    fullname: Klein
– volume: 8
  start-page: 1979
  year: 2014
  ident: CR72
  article-title: Efficacy of short novel antimicrobial and anti-inflammatory peptides in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) skin infection
  publication-title: Drug Des. Devel. Ther.
  doi: 10.2147/DDDT.S72129
  contributor:
    fullname: Seleem
– volume: 15
  start-page: 453
  year: 2017
  ident: CR6
  article-title: Persistent bacterial infections and persister cells
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.42
  contributor:
    fullname: Helaine
– volume: 138
  start-page: 6532
  year: 2016
  end-page: 6540
  ident: CR52
  article-title: Combined molecular dynamics simulations and experimental studies of the structure and dynamics of poly-amido-saccharides
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b01837
  contributor:
    fullname: Chin
– volume: 18
  start-page: 4180
  year: 2018
  end-page: 4187
  ident: CR75
  article-title: Block copolymer nanoparticles remove biofilms of drug-resistant gram-positive bacteria by nanoscale bacterial debridement
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.8b01000
  contributor:
    fullname: Li
– volume: 157
  start-page: 539
  year: 2014
  end-page: 548
  ident: CR7
  article-title: Molecular mechanisms underlying bacterial persisters
  publication-title: Cell
  doi: 10.1016/j.cell.2014.02.050
  contributor:
    fullname: Gerdes
– volume: 15
  start-page: 740
  year: 2017
  ident: CR69
  article-title: Targeting microbial biofilms: current and prospective therapeutic strategies
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.99
  contributor:
    fullname: Hall-Stoodley
– volume: 353
  start-page: 157
  year: 2014
  end-page: 164
  ident: CR57
  article-title: Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistant Staphylococcus aureus strain LAC
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/1574-6968.12424
  contributor:
    fullname: O’Gara
– volume: 404
  start-page: 565
  year: 2000
  ident: CR23
  article-title: Antibiotics: non-haemolytic β-amino-acid oligomers
  publication-title: Nature
  doi: 10.1038/35007145
  contributor:
    fullname: Gellman
– volume: 31
  start-page: 124
  year: 1998
  end-page: 134
  ident: CR42
  article-title: Helical nylons 3. Synthesis and crystal structure of poly (β-L-aspartate) s with branched alkyl side chains
  publication-title: Macromolecules
  doi: 10.1021/ma970665u
  contributor:
    fullname: Muñoz-Guerra
– volume: 354
  start-page: aaf4268
  year: 2016
  ident: CR4
  article-title: Mechanisms of bacterial persistence during stress and antibiotic exposure
  publication-title: Science
  doi: 10.1126/science.aaf4268
  contributor:
    fullname: Gerdes
– volume: 43
  start-page: 9527
  year: 2004
  end-page: 9535
  ident: CR30
  article-title: Antimicrobial 14-helical β-peptides: potent bilayer disrupting agents
  publication-title: Biochemistry
  doi: 10.1021/bi049414l
  contributor:
    fullname: Epand
– volume: 51
  start-page: S183
  year: 2010
  end-page: S197
  ident: CR15
  article-title: Serious infections caused by methicillin-resistant Staphylococcus aureus
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/653519
  contributor:
    fullname: Razonable
– volume: 25
  start-page: 362
  year: 2012
  end-page: 386
  ident: CR13
  article-title: Predictors of mortality in Staphylococcus aureus bacteremia
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.05022-11
  contributor:
    fullname: Van Hal
– volume: 38
  start-page: 1595
  year: 1999
  end-page: 1597
  ident: CR38
  article-title: Pleated sheets and turns of β‐peptides with proteinogenic side chains
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/(SICI)1521-3773(19990601)38:11<1595::AID-ANIE1595>3.0.CO;2-0
  contributor:
    fullname: Jaun
– volume: 12
  start-page: 49
  year: 2014
  ident: CR3
  article-title: Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro3161
  contributor:
    fullname: Höök
– volume: 351
  start-page: aad3292
  year: 2016
  ident: CR77
  article-title: Multidrug evolutionary strategies to reverse antibiotic resistance
  publication-title: Science
  doi: 10.1126/science.aad3292
  contributor:
    fullname: Kishony
– volume: 131
  start-page: 9735
  year: 2009
  end-page: 9745
  ident: CR45
  article-title: Structure− activity relationships among random nylon-3 copolymers that mimic antibacterial host-defense peptides
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja901613g
  contributor:
    fullname: Gellman
– volume: 10
  start-page: eaan4044
  year: 2018
  ident: CR19
  article-title: The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aan4044
  contributor:
    fullname: de Breij
– volume: 12
  start-page: e1005671
  year: 2016
  ident: CR63
  article-title: Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1005671
  contributor:
    fullname: O’Gara
– volume: 20
  start-page: 62
  year: 1987
  end-page: 68
  ident: CR43
  article-title: Helical conformations in a polyamide of the nylon-3 family
  publication-title: Macromolecules
  doi: 10.1021/ma00167a013
  contributor:
    fullname: Fernandez-Santin
– volume: 81
  start-page: 2141
  year: 1998
  end-page: 2156
  ident: CR53
  article-title: (S)-β3-homolysine-and (S)-β3-homoserine-containing β-peptides: CD spectra in aqueous solution
  publication-title: Helv. Chim. Acta
  doi: 10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5
  contributor:
    fullname: Seebach
– volume: 22
  start-page: 1417
  year: 2015
  end-page: 1423
  ident: CR40
  article-title: Geometrically precise building blocks: the self-assembly of β-peptides
  publication-title: Chem. Biol.
  doi: 10.1016/j.chembiol.2015.10.005
  contributor:
    fullname: Aguilar
– ident: CR9
– volume: 228
  start-page: 1
  year: 2016
  end-page: 16
  ident: CR68
  article-title: Hemolysis by surfactants—a review
  publication-title: Adv. Colloid Interface Sci.
  doi: 10.1016/j.cis.2015.10.011
  contributor:
    fullname: Perrin
– volume: 101
  start-page: 3219
  year: 2001
  end-page: 3232
  ident: CR37
  article-title: β-Peptides: from structure to function
  publication-title: Chem. Rev.
  doi: 10.1021/cr000045i
  contributor:
    fullname: DeGrado
– volume: 136
  start-page: 4333
  year: 2014
  end-page: 4342
  ident: CR46
  article-title: Structure–activity relationships among antifungal nylon-3 polymers: identification of materials active against drug-resistant strains of Candida albicans
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja500036r
  contributor:
    fullname: Liu
– volume: 67
  start-page: 5427
  year: 1999
  end-page: 5433
  ident: CR62
  article-title: The intercellular adhesion (ica) locus is present in Staphylococcus aureus and is required for biofilm formation
  publication-title: Infect. Immun.
  contributor:
    fullname: Götz
– ident: CR5
– volume: 375
  start-page: 1557
  year: 2010
  end-page: 1568
  ident: CR11
  article-title: Community-associated meticillin-resistant Staphylococcus aureus
  publication-title: Lancet
  doi: 10.1016/S0140-6736(09)61999-1
  contributor:
    fullname: Chambers
– volume: 4
  start-page: 153rv110
  year: 2012
  ident: CR70
  article-title: Biomaterial-associated infection: locating the finish line in the race for the surface
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3004528
  contributor:
    fullname: Busscher
– volume: 556
  start-page: 103
  year: 2018
  end-page: 107
  ident: CR18
  article-title: A new class of synthetic retinoid antibiotics effective against bacterial persisters
  publication-title: Nature
  doi: 10.1038/nature26157
  contributor:
    fullname: Kim
– year: 2017
  ident: CR8
  publication-title: Global Priority List of Antibiotic-resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics
– volume: 43
  start-page: 3575
  year: 2014
  end-page: 3594
  ident: CR21
  article-title: Peptidomimetics via modifications of amino acids and peptide bonds
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/c3cs60384a
  contributor:
    fullname: Katritzky
– volume: 25
  start-page: 657
  year: 2007
  ident: CR25
  article-title: Improved antimicrobial peptides based on acyl-lysine oligomers
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1309
  contributor:
    fullname: Radzishevsky
– volume: 129
  start-page: 15474
  year: 2007
  end-page: 15476
  ident: CR44
  article-title: Mimicry of antimicrobial host-defense peptides by random copolymers
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja077288d
  contributor:
    fullname: Mowery
– volume: 517
  start-page: 455
  year: 2015
  ident: CR51
  article-title: A new antibiotic kills pathogens without detectable resistance
  publication-title: Nature
  doi: 10.1038/nature14098
  contributor:
    fullname: Ling
– volume: 136
  start-page: 4410
  year: 2014
  end-page: 4418
  ident: CR47
  article-title: Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja500367u
  contributor:
    fullname: Liu
– volume: 16
  year: 2016
  ident: CR71
  article-title: Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-016-0737-0
  contributor:
    fullname: Mottola
– ident: CR10
– volume: 11
  start-page: 37
  year: 2011
  ident: CR36
  article-title: Designing antimicrobial peptides: form follows function
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3591
  contributor:
    fullname: Schneider
– volume: 6
  start-page: 269
  year: 2004
  end-page: 275
  ident: CR61
  article-title: Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system
  publication-title: Cell. Microbiol.
  doi: 10.1046/j.1462-5822.2004.00367.x
  contributor:
    fullname: Vuong
– volume: 28
  start-page: 1711
  year: 2007
  end-page: 1720
  ident: CR60
  article-title: Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2006.11.046
  contributor:
    fullname: Rohde
– volume: 175
  start-page: 3810
  year: 2005
  end-page: 3818
  ident: CR31
  article-title: T cell determinants incorporating β-amino acid residues are protease resistant and remain immunogenic in vivo
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.175.6.3810
  contributor:
    fullname: Webb
– ident: CR56
– volume: 57
  start-page: 4689
  year: 2013
  end-page: 4698
  ident: CR35
  article-title: Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00427-13
  contributor:
    fullname: Sparr
– volume: 112
  start-page: 4552
  year: 2015
  end-page: 4557
  ident: CR33
  article-title: Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1420380112
  contributor:
    fullname: Checco
– volume: 311
  start-page: 53
  year: 1984
  ident: CR41
  article-title: A pseudo α-helix from poly (α-isobutyl-L-aspartate), a nylon-3 derivative
  publication-title: Nature
  doi: 10.1038/311053a0
  contributor:
    fullname: Subirana
– volume: 12
  start-page: 362
  year: 2014
  end-page: 374
  ident: CR34
  article-title: Screening nylon-3 polymers, a new class of cationic amphiphiles, for siRNA delivery
  publication-title: Mol. Pharm.
  doi: 10.1021/mp5004724
  contributor:
    fullname: Nadithe
– volume: 56
  start-page: 4508
  year: 2012
  end-page: 4510
  ident: CR66
  article-title: A model for evaluating topical antimicrobial efficacy against methicillin-resistant Staphylococcus aureus biofilms in superficial murine wounds
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00467-12
  contributor:
    fullname: Carson
– volume: 123
  start-page: 7553
  year: 2001
  end-page: 7559
  ident: CR29
  article-title: De novo design, synthesis, and characterization of antimicrobial β-peptides
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0107475
  contributor:
    fullname: DeGrado
– volume: 63
  start-page: 485
  year: 2008
  end-page: 488
  ident: CR17
  article-title: Impact of biofilm on the in vitro activity of vancomycin alone and in combination with tigecycline and rifampicin against Staphylococcus aureus
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkn513
  contributor:
    fullname: Poppens
– volume: 41
  start-page: 1366
  year: 2008
  end-page: 1375
  ident: CR32
  article-title: β-Peptidic peptidomimetics
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar700263g
  contributor:
    fullname: Gardiner
– volume: 47
  start-page: 647
  year: 2001
  end-page: 650
  ident: CR50
  article-title: Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/47.5.647
  contributor:
    fullname: Chopra
– volume: 50
  start-page: 765
  year: 2006
  end-page: 769
  ident: CR49
  article-title: Single-and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.50.2.765-769.2006
  contributor:
    fullname: Kosowska-Shick
– volume: 3
  start-page: 2570
  year: 2012
  end-page: 2575
  ident: CR24
  article-title: Design and synthesis of unprecedented cyclic γ-AApeptides for antimicrobial development
  publication-title: Chem. Sci.
  doi: 10.1039/c2sc20428b
  contributor:
    fullname: Wu
– volume: 51
  start-page: 244
  year: 1997
  end-page: 247
  ident: CR27
  article-title: The biological stability of β-peptides: no interactions between α-and β-peptidic structures? CHIMIA International
  publication-title: J. Chem.
  contributor:
    fullname: Seebach
– volume: 1
  start-page: 16051
  year: 2016
  ident: CR2
  article-title: Persister formation in Staphylococcus aureus is associated with ATP depletion
  publication-title: Nat. Microbiol.
  doi: 10.1038/nmicrobiol.2016.51
  contributor:
    fullname: Conlon
– volume: 10
  start-page: 3443
  year: 2016
  end-page: 3452
  ident: CR59
  article-title: Sticky matrix: adhesion mechanism of the staphylococcal polysaccharide intercellular adhesin
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b07515
  contributor:
    fullname: Formosa-Dague
– volume: 173
  start-page: 1970
  year: 2013
  end-page: 1978
  ident: CR12
  article-title: National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011
  publication-title: JAMA Intern. Med.
  contributor:
    fullname: Dantes
– volume: 10
  start-page: 39
  year: 2012
  ident: CR73
  article-title: Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2695
  contributor:
    fullname: Kjelleberg
– volume: 468
  start-page: 259
  year: 2015
  end-page: 270
  ident: CR74
  article-title: Mechanisms of biofilm inhibition and degradation by antimicrobial peptides
  publication-title: Biochem. J.
  doi: 10.1042/BJ20141251
  contributor:
    fullname: Shai
– volume: 1788
  start-page: 1687
  year: 2009
  end-page: 1692
  ident: CR67
  article-title: Control of cell selectivity of antimicrobial peptides
  publication-title: Biochim. Biophys. Acta Biomembr.
  doi: 10.1016/j.bbamem.2008.09.013
  contributor:
    fullname: Matsuzaki
– volume: 387
  start-page: 381
  year: 1997
  ident: CR39
  article-title: Residue-based control of helix shape in beta-peptide oligomers
  publication-title: Nature
  doi: 10.1038/387381a0
  contributor:
    fullname: Appella
– ident: CR76
– volume: 105
  start-page: 2794
  year: 2008
  end-page: 2799
  ident: CR22
  article-title: Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0708254105
  contributor:
    fullname: Chongsiriwatana
– volume: 6
  start-page: e17936
  year: 2011
  ident: CR48
  article-title: A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0017936
  contributor:
    fullname: Monecke
– volume: 20
  start-page: 647
  year: 2012
  end-page: 657
  ident: CR65
  article-title: A review of the scientific evidence for biofilms in wounds
  publication-title: Wound Repair Regen.
  doi: 10.1111/j.1524-475X.2012.00836.x
  contributor:
    fullname: Percival
– volume: 127
  start-page: 167
  year: 2005
  end-page: 178
  ident: CR54
  article-title: Relationship between side chain structure and 14-helix stability of β3-peptides in water
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0459375
  contributor:
    fullname: Kritzer
– volume: 41
  start-page: 430
  year: 2017
  end-page: 449
  ident: CR1
  article-title: Antibiotic resistance in Staphylococcus aureus. Current status and future prospects
  publication-title: FEMS Microbiol. Rev.
  doi: 10.1093/femsre/fux007
  contributor:
    fullname: Foster
– ident: CR20
– volume: 124
  start-page: 7324
  year: 2002
  end-page: 7330
  ident: CR28
  article-title: Mimicry of host-defense peptides by unnatural oligomers: antimicrobial β-peptides
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0260871
  contributor:
    fullname: Gellman
– volume: 28
  start-page: 1711
  year: 2007
  ident: 12702_CR60
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2006.11.046
  contributor:
    fullname: H Rohde
– volume: 3
  start-page: 2570
  year: 2012
  ident: 12702_CR24
  publication-title: Chem. Sci.
  doi: 10.1039/c2sc20428b
  contributor:
    fullname: H Wu
– volume: 20
  start-page: 62
  year: 1987
  ident: 12702_CR43
  publication-title: Macromolecules
  doi: 10.1021/ma00167a013
  contributor:
    fullname: J Fernandez-Santin
– ident: 12702_CR5
  doi: 10.1007/978-3-319-09782-4_1
– volume: 77
  start-page: 3978
  year: 2009
  ident: 12702_CR58
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.00616-09
  contributor:
    fullname: M Vergara-Irigaray
– volume: 10
  start-page: eaan4044
  year: 2018
  ident: 12702_CR19
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aan4044
  contributor:
    fullname: A de Breij
– volume: 20
  start-page: 647
  year: 2012
  ident: 12702_CR65
  publication-title: Wound Repair Regen.
  doi: 10.1111/j.1524-475X.2012.00836.x
  contributor:
    fullname: SL Percival
– volume: 51
  start-page: S183
  year: 2010
  ident: 12702_CR15
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/653519
  contributor:
    fullname: H Boucher
– volume: 105
  start-page: 2794
  year: 2008
  ident: 12702_CR22
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0708254105
  contributor:
    fullname: NP Chongsiriwatana
– volume: 112
  start-page: 4552
  year: 2015
  ident: 12702_CR33
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1420380112
  contributor:
    fullname: JW Checco
– volume: 38
  start-page: 1595
  year: 1999
  ident: 12702_CR38
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/(SICI)1521-3773(19990601)38:11<1595::AID-ANIE1595>3.0.CO;2-0
  contributor:
    fullname: D Seebach
– ident: 12702_CR20
  doi: 10.1159/000491497
– volume: 6
  start-page: 269
  year: 2004
  ident: 12702_CR61
  publication-title: Cell. Microbiol.
  doi: 10.1046/j.1462-5822.2004.00367.x
  contributor:
    fullname: C Vuong
– volume: 22
  start-page: 1417
  year: 2015
  ident: 12702_CR40
  publication-title: Chem. Biol.
  doi: 10.1016/j.chembiol.2015.10.005
  contributor:
    fullname: RD Gopalan
– volume: 56
  start-page: 4508
  year: 2012
  ident: 12702_CR66
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00467-12
  contributor:
    fullname: ED Roche
– volume: 43
  start-page: 3575
  year: 2014
  ident: 12702_CR21
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/c3cs60384a
  contributor:
    fullname: I Avan
– volume: 123
  start-page: 7553
  year: 2001
  ident: 12702_CR29
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0107475
  contributor:
    fullname: D Liu
– volume: 1
  start-page: 16051
  year: 2016
  ident: 12702_CR2
  publication-title: Nat. Microbiol.
  doi: 10.1038/nmicrobiol.2016.51
  contributor:
    fullname: BP Conlon
– volume: 43
  start-page: 9527
  year: 2004
  ident: 12702_CR30
  publication-title: Biochemistry
  doi: 10.1021/bi049414l
  contributor:
    fullname: RF Epand
– volume: 354
  start-page: aaf4268
  year: 2016
  ident: 12702_CR4
  publication-title: Science
  doi: 10.1126/science.aaf4268
  contributor:
    fullname: A Harms
– volume: 157
  start-page: 539
  year: 2014
  ident: 12702_CR7
  publication-title: Cell
  doi: 10.1016/j.cell.2014.02.050
  contributor:
    fullname: E Maisonneuve
– volume: 404
  start-page: 565
  year: 2000
  ident: 12702_CR23
  publication-title: Nature
  doi: 10.1038/35007145
  contributor:
    fullname: EA Porter
– volume: 468
  start-page: 259
  year: 2015
  ident: 12702_CR74
  publication-title: Biochem. J.
  doi: 10.1042/BJ20141251
  contributor:
    fullname: L-a Segev-Zarko
– volume: 51
  start-page: 244
  year: 1997
  ident: 12702_CR27
  publication-title: J. Chem.
  contributor:
    fullname: T Hintermann
– volume: 6
  start-page: e17936
  year: 2011
  ident: 12702_CR48
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0017936
  contributor:
    fullname: S Monecke
– ident: 12702_CR10
– volume: 10
  start-page: 39
  year: 2012
  ident: 12702_CR73
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro2695
  contributor:
    fullname: D McDougald
– volume: 12
  start-page: e1005671
  year: 2016
  ident: 12702_CR63
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1005671
  contributor:
    fullname: M Zapotoczna
– volume: 11
  start-page: 37
  year: 2011
  ident: 12702_CR36
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3591
  contributor:
    fullname: CD Fjell
– volume: 351
  start-page: aad3292
  year: 2016
  ident: 12702_CR77
  publication-title: Science
  doi: 10.1126/science.aad3292
  contributor:
    fullname: M Baym
– volume: 15
  start-page: 740
  year: 2017
  ident: 12702_CR69
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.99
  contributor:
    fullname: H Koo
– volume: 25
  start-page: 362
  year: 2012
  ident: 12702_CR13
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.05022-11
  contributor:
    fullname: SJ Van Hal
– volume: 503
  start-page: 365
  year: 2013
  ident: 12702_CR64
  publication-title: Nature
  doi: 10.1038/nature12790
  contributor:
    fullname: B Conlon
– volume: 175
  start-page: 3810
  year: 2005
  ident: 12702_CR31
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.175.6.3810
  contributor:
    fullname: AI Webb
– volume: 1788
  start-page: 1687
  year: 2009
  ident: 12702_CR67
  publication-title: Biochim. Biophys. Acta Biomembr.
  doi: 10.1016/j.bbamem.2008.09.013
  contributor:
    fullname: K Matsuzaki
– volume-title: Global Priority List of Antibiotic-resistant Bacteria to Guide Research, Discovery, and Development of New Antibiotics
  year: 2017
  ident: 12702_CR8
  contributor:
    fullname: Organization, W. H.
– volume: 136
  start-page: 4333
  year: 2014
  ident: 12702_CR46
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja500036r
  contributor:
    fullname: R Liu
– volume: 52
  start-page: 734
  year: 1998
  ident: 12702_CR26
  publication-title: J. Chem.
  contributor:
    fullname: D Seebach
– volume: 63
  start-page: 485
  year: 2008
  ident: 12702_CR17
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkn513
  contributor:
    fullname: WE Rose
– volume: 375
  start-page: 1557
  year: 2010
  ident: 12702_CR11
  publication-title: Lancet
  doi: 10.1016/S0140-6736(09)61999-1
  contributor:
    fullname: FR DeLeo
– volume: 50
  start-page: 765
  year: 2006
  ident: 12702_CR49
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.50.2.765-769.2006
  contributor:
    fullname: K Kosowska-Shick
– volume: 31
  start-page: 124
  year: 1998
  ident: 12702_CR42
  publication-title: Macromolecules
  doi: 10.1021/ma970665u
  contributor:
    fullname: M García-Alvarez
– volume: 136
  start-page: 4410
  year: 2014
  ident: 12702_CR47
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja500367u
  contributor:
    fullname: R Liu
– volume: 387
  start-page: 381
  year: 1997
  ident: 12702_CR39
  publication-title: Nature
  doi: 10.1038/387381a0
  contributor:
    fullname: DH Appella
– volume: 127
  start-page: 167
  year: 2005
  ident: 12702_CR54
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0459375
  contributor:
    fullname: JA Kritzer
– volume: 311
  start-page: 53
  year: 1984
  ident: 12702_CR41
  publication-title: Nature
  doi: 10.1038/311053a0
  contributor:
    fullname: J Fernandez-Santin
– volume: 228
  start-page: 1
  year: 2016
  ident: 12702_CR68
  publication-title: Adv. Colloid Interface Sci.
  doi: 10.1016/j.cis.2015.10.011
  contributor:
    fullname: M Manaargadoo-Catin
– volume: 10
  start-page: 3443
  year: 2016
  ident: 12702_CR59
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b07515
  contributor:
    fullname: C Formosa-Dague
– volume: 517
  start-page: 455
  year: 2015
  ident: 12702_CR51
  publication-title: Nature
  doi: 10.1038/nature14098
  contributor:
    fullname: LL Ling
– volume: 65
  start-page: 1921
  year: 2017
  ident: 12702_CR16
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/cid/cix640
  contributor:
    fullname: EY Klein
– volume: 12
  start-page: 362
  year: 2014
  ident: 12702_CR34
  publication-title: Mol. Pharm.
  doi: 10.1021/mp5004724
  contributor:
    fullname: V Nadithe
– volume: 353
  start-page: 157
  year: 2014
  ident: 12702_CR57
  publication-title: FEMS Microbiol. Lett.
  doi: 10.1111/1574-6968.12424
  contributor:
    fullname: DP O’Halloran
– ident: 12702_CR9
– volume: 67
  start-page: 5427
  year: 1999
  ident: 12702_CR62
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.67.10.5427-5433.1999
  contributor:
    fullname: SE Cramton
– volume: 8
  start-page: 1979
  year: 2014
  ident: 12702_CR72
  publication-title: Drug Des. Devel. Ther.
  doi: 10.2147/DDDT.S72129
  contributor:
    fullname: MF Mohamed
– ident: 12702_CR76
  doi: 10.1038/s41579-018-0019-y
– volume: 15
  start-page: 453
  year: 2017
  ident: 12702_CR6
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.42
  contributor:
    fullname: RA Fisher
– ident: 12702_CR56
  doi: 10.1128/JB.00011-12
– volume: 47
  start-page: 647
  year: 2001
  ident: 12702_CR50
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/47.5.647
  contributor:
    fullname: AJ O’neill
– volume: 12
  start-page: 49
  year: 2014
  ident: 12702_CR3
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro3161
  contributor:
    fullname: TJ Foster
– volume: 129
  start-page: 15474
  year: 2007
  ident: 12702_CR44
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja077288d
  contributor:
    fullname: BP Mowery
– volume: 4
  start-page: 153rv110
  year: 2012
  ident: 12702_CR70
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3004528
  contributor:
    fullname: HJ Busscher
– volume: 16
  year: 2016
  ident: 12702_CR71
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-016-0737-0
  contributor:
    fullname: C Mottola
– volume: 41
  start-page: 430
  year: 2017
  ident: 12702_CR1
  publication-title: FEMS Microbiol. Rev.
  doi: 10.1093/femsre/fux007
  contributor:
    fullname: TJ Foster
– volume: 57
  start-page: 4689
  year: 2013
  ident: 12702_CR35
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00427-13
  contributor:
    fullname: C Sparr
– volume: 13
  start-page: 620
  year: 2015
  ident: 12702_CR55
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro3480
  contributor:
    fullname: L Brown
– volume: 41
  start-page: 1366
  year: 2008
  ident: 12702_CR32
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar700263g
  contributor:
    fullname: D Seebach
– volume: 81
  start-page: 2141
  year: 1998
  ident: 12702_CR53
  publication-title: Helv. Chim. Acta
  doi: 10.1002/(SICI)1522-2675(19981216)81:12<2141::AID-HLCA2141>3.0.CO;2-5
  contributor:
    fullname: S Abele
– volume: 25
  start-page: 657
  year: 2007
  ident: 12702_CR25
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1309
  contributor:
    fullname: IS Radzishevsky
– volume: 124
  start-page: 7324
  year: 2002
  ident: 12702_CR28
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0260871
  contributor:
    fullname: EA Porter
– volume: 101
  start-page: 3219
  year: 2001
  ident: 12702_CR37
  publication-title: Chem. Rev.
  doi: 10.1021/cr000045i
  contributor:
    fullname: RP Cheng
– volume: 18
  start-page: 4180
  year: 2018
  ident: 12702_CR75
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.8b01000
  contributor:
    fullname: J Li
– volume: 138
  start-page: 6532
  year: 2016
  ident: 12702_CR52
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b01837
  contributor:
    fullname: SL Chin
– volume: 357
  start-page: 380
  year: 2007
  ident: 12702_CR14
  publication-title: New Engl. J. Med.
  doi: 10.1056/NEJMcp070747
  contributor:
    fullname: RS Daum
– volume: 556
  start-page: 103
  year: 2018
  ident: 12702_CR18
  publication-title: Nature
  doi: 10.1038/nature26157
  contributor:
    fullname: W Kim
– volume: 131
  start-page: 9735
  year: 2009
  ident: 12702_CR45
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja901613g
  contributor:
    fullname: BP Mowery
– volume: 173
  start-page: 1970
  year: 2013
  ident: 12702_CR12
  publication-title: JAMA Intern. Med.
  contributor:
    fullname: R Dantes
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Snippet The treatment of bacterial infections is hindered by the presence of biofilms and metabolically inactive persisters. Here, we report the synthesis of an...
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and...
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SubjectTerms 13/106
14/19
140/131
140/58
147/135
147/143
3T3 Cells
45/22
45/77
631/326/22
631/326/41
631/326/421
639/638/455
64
64/60
Animals
Antibacterial activity
Antibiotics
Bacteria
Bacterial diseases
Bacterial infections
beta-Lactams - chemical synthesis
beta-Lactams - pharmacology
beta-Lactams - therapeutic use
Biocompatibility
Biofilms
Biofilms - drug effects
Daptomycin
Drug resistance
Drug Resistance, Multiple, Bacterial
Glucose
Glucose - chemical synthesis
Glucose - pharmacology
Glucose - therapeutic use
Humanities and Social Sciences
Humans
In Vitro Techniques
Infections
Lysine
Lysine - analogs & derivatives
Lysine - chemical synthesis
Lysine - pharmacology
Lysine - therapeutic use
Methicillin
Methicillin-Resistant Staphylococcus aureus - drug effects
Mice
Microbial Sensitivity Tests
multidisciplinary
Peptides
Polymerization
Replication
Ring opening polymerization
Science
Science (multidisciplinary)
Staphylococcal Skin Infections - drug therapy
Staphylococcus aureus
Staphylococcus infections
Toxicity
Vancomycin
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Title Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
URI https://link.springer.com/article/10.1038/s41467-019-12702-8
https://www.ncbi.nlm.nih.gov/pubmed/31636263
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https://pubmed.ncbi.nlm.nih.gov/PMC6803644
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Volume 10
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