Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

• Published in: Nature communications Vol. 10; no. 1; pp. 1076 - 14
• Main Authors: Yang, Wenting, Tao, Yuandong, Wu, Yan, Zhao, Xinyuan, Ye, Weijie, Zhao, Dianyuan, Fu, Ling, Tian, Caiping, Yang, Jing, He, Fuchu, Tang, Li
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.03.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 631/250/24/2510; 631/250/2504/223/1699; 631/250/2504/342/1726; 631/250/256/2516; Acetaminophen - toxicity; Adoptive transfer; Adoptive Transfer - methods; Animals; Bone Marrow Transplantation; Cells, Cultured; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - immunology; Chemical and Drug Induced Liver Injury - pathology; Colony-stimulating factor; Conversion; CYBB protein; Depletion; Disease Models, Animal; Granulocyte colony-stimulating factor; Humanities and Social Sciences; Humans; Inflammation; Leukocytes (granulocytic); Leukocytes (neutrophilic); Liver; Liver - immunology; Liver - pathology; Liver Regeneration - immunology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Male; Mice; Mice, Knockout; Monocytes; multidisciplinary; NAD(P)H oxidase; NADPH Oxidase 2 - genetics; NADPH Oxidase 2 - immunology; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Neutrophils - transplantation; Phagocytes; Primary Cell Culture; Reactive oxygen species; Reactive Oxygen Species - metabolism; Repair; Science; Science (multidisciplinary); Transplantation Chimera

Phagocytes, including neutrophils and macrophages, have been suggested to function in a cooperative way in the initial phase of inflammatory responses, but their interaction and integration in the resolution of inflammation and tissue repair remain unclear. Here we show that neutrophils have crucial...