Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

• Published in: Nature communications Vol. 8; no. 1; pp. 517 - 12
• Main Authors: Chiu, David Kung-Chun, Tse, Aki Pui-Wah, Xu, Iris Ming-Jing, Di Cui, Jane, Lai, Robin Kit-Ho, Li, Lynna Lan, Koh, Hui-Yu, Tsang, Felice Ho-Ching, Wei, Larry Lai, Wong, Chun-Ming, Ng, Irene Oi-Lin, Wong, Carmen Chak-Lui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.09.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1504/1610/4029; 631/67/327; 631/67/580; AMP; Cancer; Differentiation; Hepatocellular carcinoma; Humanities and Social Sciences; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-inducible factors; Immune checkpoint; Immune checkpoint inhibitors; Immunosuppression; Immunosurveillance; Liver cancer; multidisciplinary; Science; Science (multidisciplinary); Suppressor cells

Myeloid-derived suppressor cells (MDSCs) possess immunosuppressive activities, which allow cancers to escape immune surveillance and become non-responsive to immune checkpoints blockade. Here we report hypoxia as a cause of MDSC accumulation. Using hepatocellular carcinoma (HCC) as a cancer model, w...