Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo

• Published in: Scientific reports Vol. 7; no. 1; pp. 5806 - 13
• Main Authors: Parhi, Priyambada, Suklabaidya, Sujit, Kumar Sahoo, Sanjeeb
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.07.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/2; 13/31; 14; 14/19; 14/3; 631/67/1059/99; 692/4028/67/1059/99; 82; 82/29; 96; Animals; Benzylisoquinolines - pharmacology; Benzylisoquinolines - therapeutic use; Bioavailability; Cancer; Carcinogenesis - drug effects; Carcinogenesis - pathology; Cell Death - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Coumarins - chemistry; Cytotoxicity; Humanities and Social Sciences; Humans; Inhibitory Concentration 50; Lipids - chemistry; Melanoma; Melanoma, Experimental - pathology; Metastases; Metastasis; Mice, Inbred C57BL; Mitochondria - drug effects; Mitochondria - metabolism; multidisciplinary; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Neoplasm Invasiveness; Neoplasm Metastasis - drug therapy; Science; Science (multidisciplinary); Tumor cell lines

Research on metastasis is gaining momentum for effective cancer management. Berbamine (BBM) has the potency to act as a therapeutic in multiple cancers and cancer metastasis. However, the major limitation of the compound includes poor bioavailability at the tumor site due to short plasma half-life....