Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation

• Published in: Translational psychiatry Vol. 11; no. 1; pp. 632 - 14
• Main Authors: Moore, Sarah R., Halldorsdottir, Thorhildur, Martins, Jade, Lucae, Susanne, Müller-Myhsok, Bertram, Müller, Nikola S., Piechaczek, Charlotte, Feldmann, Lisa, Freisleder, Franz Joseph, Greimel, Ellen, Schulte-Körne, Gerd, Binder, Elisabeth B., Arloth, Janine
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.12.2021; Nature Publishing Group
• Subjects: 38; 38/39; 45/61; 631/208/212; 692/53/2423; Adolescent; Behavioral Sciences; Biological Psychology; Child; Depressive Disorder, Major - genetics; Female; Gender differences; Gene expression; Gene Expression Regulation; Genome-Wide Association Study; Glucocorticoids; Humans; Male; Medicine; Medicine & Public Health; Neurosciences; Pharmacotherapy; Psychiatry; Quantitative Trait Loci; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; Sex Characteristics; Transcriptome

Substantial sex differences have been reported in the physiological response to stress at multiple levels, including the release of the stress hormone, cortisol. Here, we explore the genomic variants in 93 females and 196 males regulating the initial transcriptional response to cortisol via glucocor...