Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

• Published in: Nature communications Vol. 9; no. 1; pp. 191 - 13
• Main Authors: Fang, Tian, Lv, Hongwei, Lv, Guishuai, Li, Ting, Wang, Changzheng, Han, Qin, Yu, Lexing, Su, Bo, Guo, Linna, Huang, Shanna, Cao, Dan, Tang, Liang, Tang, Shanhua, Wu, Mengchao, Yang, Wen, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.01.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/109; 13/44; 13/51; 13/89; 13/95; 14; 14/5; 38; 692/4020/4021/1607/1610/4029; 692/4028/67/327; Activation; Cancer; Crosstalk; Cytokines; Exosomes; Fibroblasts; Hepatocellular carcinoma; Humanities and Social Sciences; Inflammation; Interleukin 6; Interleukin 8; Liver; Liver cancer; Lung cancer; Metastases; Metastasis; multidisciplinary; NF-κB protein; Science; Science (multidisciplinary); Signaling; Stroma; Tumor cells; Tumors

The communication between tumor-derived elements and stroma in the metastatic niche has a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control metastatic niche formation are not fully understood. Here we report that in the lung metastatic niche, high-metast...