SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN
Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-l-propen-l-yl]cephalosporin (10) showed excellent activity against G...
Saved in:
| Published in | Journal of antibiotics Vol. 46; no. 5; pp. 833 - 839 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
TOKYO
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
1993
JAPAN ANTIBIOT RES ASSN Japan Antibiotics Research Association |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-l-propen-l-yl]cephalosporin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. |
|---|---|
| AbstractList | Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4- ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-1-propen-1-yl]cephalospo rin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4- ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-1-propen-1-yl]cephalospo rin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia.Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4- ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-1-propen-1-yl]cephalospo rin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. CePhalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-1-propen-1-yl]cephalosporin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-ylcarbonyloxy)methylcephalosporin (14) and 3-[(E)-3-(catechol-4-ylcarbonyloxy)-l-propen-l-yl]cephalosporin (10) showed excellent activity against Gram-negative activity including ceftazidime-resistant Escherichia coli, Pseudomonas aeruginosa, Xanthomonas maltophilia and Pseudomonas cepacia. |
| Author | IIMURA, SEIJI OKITA, TAKAAKI IMAE, KIYOTO MASUYOSHI, SHINJI HASEGAWA, TOSHIFUMI KAMACHI, HAJIME KAMEI, HIDEO |
| Author_xml | – sequence: 1 fullname: IIMURA, SEIJI organization: Birstol-Myers Squibb Research Institute – sequence: 1 fullname: OKITA, TAKAAKI organization: Birstol-Myers Squibb Research Institute – sequence: 1 fullname: KAMACHI, HAJIME organization: Birstol-Myers Squibb Research Institute – sequence: 1 fullname: HASEGAWA, TOSHIFUMI organization: Birstol-Myers Squibb Research Institute – sequence: 1 fullname: IMAE, KIYOTO organization: Birstol-Myers Squibb Research Institute – sequence: 1 fullname: KAMEI, HIDEO organization: Birstol-Myers Squibb Research Institute – sequence: 1 fullname: MASUYOSHI, SHINJI organization: Birstol-Myers Squibb Research Institute |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4876864$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/8514638$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkkFr2zAUgMXo6NJuf2Aw0GHsMpJJliNLR9dxazFjl9or9DCELMubi2N3lsPov69CvLTsMHaQntD7vveEeGfgpB96A8B7jFYBpv4X1U9t1Q5Tq-3KpytGyCuwwIzhJfYpPwELhDy8ZMxDb8CZtfcIkYAE7BScsrUjCFuA78VdViZxIQoYZhu3SnERRmV8I8IUuoO4FeUdzC9hFF8nYZoX1_mNyAqYhLciu4IhjMIyjpI8hSKDrhCMCCzExsUkFNlb8LpRnTXv5ngOvl3GZZQs0_xKRGG61BTRaal5TbhXV76uPcqwqrjWNW7qWhPEDcKUNobwinLdkGAdGM_UQWAC1FSVu9aYnINPh7oP4_BrZ-wkt63VputUb4adlU7iPkeBAz_M4K7amlo-jO1WjY9y_g-X_zjnldWqa0bV69YeMZ8FlFHfYZ8P2G9TDY3Vrem1OVIh5pykG845Qgjvm7L_p6N2UlM79NGw66dnVY-DtaNppJ7z06jaTmIk95MgX0yC9Kl0k-BU7y_1T8d_Sl8P0r2d1I_nR6rRUZ15qWBO2V5bHzZnHyn9U43S9OQJNx_NBg |
| CODEN | JANTAJ |
| CitedBy_id | crossref_primary_10_1016_S0960_894X_01_80574_6 crossref_primary_10_1016_S0968_0896_96_00217_9 crossref_primary_10_1111_nyas_12024 |
| ContentType | Journal Article |
| Copyright | Japan Antibiotics Research Association 1993 INIST-CNRS |
| Copyright_xml | – notice: Japan Antibiotics Research Association – notice: 1993 INIST-CNRS |
| DBID | AAYXX CITATION 17B 1KM BLEPL DTL EGQ EZIWH IQODW CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.7164/antibiotics.46.833 |
| DatabaseName | CrossRef Web of Knowledge Index Chemicus Web of Science Core Collection Science Citation Index Expanded Web of Science Primary (SCIE, SSCI & AHCI) Web of Science - Science Citation Index Expanded - 1993 Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef Web of Science MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Web of Science |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1881-1469 |
| EndPage | 839 |
| ExternalDocumentID | 8514638 4876864 A1993LD99900017 10_7164_antibiotics_46_833 article_antibiotics1968_46_5_46_5_833_article_char_en |
| Genre | Journal Article Comparative Study |
| GroupedDBID | --- -~X .55 .GJ 2WC 3O- 53G 5GY ABAWZ ABJNI ACGFS AENEX AHMBA ALMA_UNASSIGNED_HOLDINGS DU5 F5P JSF JSH KQ8 OK1 RJT RNT RZJ SNYQT SOJ TKC UPT W2D X7M YQT ZGI ZXP -Q- 0R~ 29J 39C 4.4 406 41~ 70F 7X7 88E 88I 8FI 8FJ AACDK AANZL AASML AATNV AAYXX ABAKF ABBRH ABDBE ABFSG ABUWG ABZZP ACAOD ACKTT ACRQY ACSTC ACZOJ ADBBV AEFQL AEJRE AEMSY AEUYN AEVLU AEXYK AEZWR AFBBN AFDZB AFHIU AFKRA AFSHS AGAYW AGHAI AGQEE AHSBF AHWEU AIGIU AILAN AIXLP AJRNO ALFFA ALIPV AMYLF ATHPR AXYYD AYFIA AZQEC BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CITATION DIK DNIVK DPUIP DWQXO EBLON EBS EE. EIOEI EJD EMB EMOBN FDQFY FERAY FIGPU FIZPM FSGXE FYUFA GNUQQ HCIFZ HMCUK HZ~ IWAJR JSO JZLTJ M1P M2P M7P NQJWS O9- P6G PHGZM PHGZT PQQKQ PROAC PSQYO RNTTT ROL SNX SOHCF SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TR2 TSG UKHRP X7J 17B 1KM BLEPL DTL GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED GROUPED_WOS_WEB_OF_SCIENCE IQODW 3V. AAZLF ADHDB CGR CUY CVF ECM EIF NAO NPM PKN 7X8 |
| ID | FETCH-LOGICAL-c606t-c9d392db4cd2681ab9ccd1fddc309e0166fe39b69cf3757e2ed77e70fbb39bc13 |
| ISICitedReferencesCount | 7 |
| ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=A1993LD99900017 |
| ISSN | 0021-8820 |
| IngestDate | Fri Jul 11 15:57:21 EDT 2025 Wed Feb 19 02:36:08 EST 2025 Wed Apr 02 07:26:20 EDT 2025 Wed Jul 09 16:31:46 EDT 2025 Fri Aug 29 16:16:24 EDT 2025 Thu Apr 24 23:12:19 EDT 2025 Tue Jul 01 00:27:44 EDT 2025 Wed Sep 03 06:31:17 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | M14659 INVITRO ANTIPSEUDOMONAL CEPHALOSPORIN E-0702 Antibiotic Cephalosporin derivatives Microorganism growth Sensitivity resistance Synthesis Structure activity relation Molecular structure Minimum inhibitory concentration Microorganism culture Bacteria Antibacterial agent In vitro |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
| MergedId | FETCHMERGED-LOGICAL-c606t-c9d392db4cd2681ab9ccd1fddc309e0166fe39b69cf3757e2ed77e70fbb39bc13 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/antibiotics1968/46/5/46_5_833/_article/-char/en |
| PMID | 8514638 |
| PQID | 75794907 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | webofscience_primary_A1993LD99900017 proquest_miscellaneous_75794907 webofscience_primary_A1993LD99900017CitationCount crossref_citationtrail_10_7164_antibiotics_46_833 pascalfrancis_primary_4876864 pubmed_primary_8514638 crossref_primary_10_7164_antibiotics_46_833 jstage_primary_article_antibiotics1968_46_5_46_5_833_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1993-00-00 |
| PublicationDateYYYYMMDD | 1993-01-01 |
| PublicationDate_xml | – year: 1993 text: 1993-00-00 |
| PublicationDecade | 1990 |
| PublicationPlace | TOKYO |
| PublicationPlace_xml | – name: TOKYO – name: Tokyo – name: Japan |
| PublicationTitle | Journal of antibiotics |
| PublicationTitleAbbrev | J ANTIBIOT |
| PublicationTitleAlternate | J. Antibiot. |
| PublicationYear | 1993 |
| Publisher | JAPAN ANTIBIOTICS RESEARCH ASSOCIATION JAPAN ANTIBIOT RES ASSN Japan Antibiotics Research Association |
| Publisher_xml | – name: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION – name: JAPAN ANTIBIOT RES ASSN – name: Japan Antibiotics Research Association |
| References | 1) KATSU, K.; K. KITOH, M. INOUE & S. MITSUHASHI: In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin. Antimicrob. Agents Chemother. 22: 181-185, 1982 4) NAKAGAWA, S.; M. SANADA, K. MATSUDA, T. HASHIZUME, Y. ASAHI, R. USHIJIMA, N. OHTAKE & N. TANAKA: In vitro and in vivo antibacterial activities of BO-1341, a new antipseudomonal cephalosporin. Antimicrob. Agents Chemother. 33: 1423-1427, 1989 6) SANADA, M.; T. HASHIZUME, K. MATSUDA, S. NAKAGAWA & N. TANAKA: Mode of action of BO-1341: transport pathway through the outer membrane of Escherichia coli. Drugs Exptl. Clin. Res. 14: 397 - 402, 1988 7) MOCHIZUKI, H.; H. YAMADA, Y. OIKAWA, K. MURAKAMI, J. ISHIGURO, H. KOSUZUME, N. AIZAWA & E. MOCHIDA: Bactericidal activity of M14659 enhanced in low-iron environments. Antimicrob. Agents Chemother. 32: 1648-1654,1988 9) KAMACHI, H.; T. OKITA, H. HOSHI, S. OKUYAMA & T. NAITO: Synthesis of geometrical isomers of 3-(3-acetoxy and 3-carbamoyloxy-l-propenyl)cephalosporins and their structure-activity relationships. J. Antibiotics 45: 998-1001,1992 10) WEI, C. C; D. BARTKOVITZ & K. F. WEST: A facile and general synthesis of 3-(acyloxy)cephalosporins. J. Org. Chem. 57: 4027-4030, 1992 11) CORBETT, D. F.; C. H. FRIEDRICH & R. SOUTHGATE (Beecham): New aryloxymethyl-7-acylamino-3-cephem derivatives and analogues useful as broad spectrum antibacterials. Jpn. Kokai 152389 ('88), June 24, 1988 5) WATANABE, N.; T. NAGASU, K. KATSU & K. KITOH: E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the to".#-dependent iron transport system. Antimicrob. Agents Chemother. 31: 497 - 504, 1987 8) KAMACHI, H.; M. OKA, Y. NARITA, S. IIMURA, S. ABURAKI, H. YAMASHITA, K. TOMATSU, J. OKUMURA & T. NAITO: Synthesis of a new series of cephalosporins having 3-substituted-ammonio-l-propenyl group as the C-3 side chain.? J. Antibiotics 43: 533-543, 1990 2) NAKAGAWA, S.; M. SANADA, K. MATSUDA, N. HAZUMI & N. TANAKA: Biological activity of BO-1236, a new antipseudomonal cephalosporin. Antimicrob. Agents Chemother. 31: 1100 - 1105, 1987 3) MOCHIZUKI, H.; Y. OIKAWA, H. YAMADA, S. KUSAKABE, T. SHIIHARA, K. MURAKAMI, K. KATO, J. ISHIGURO & H. KOSUZUME: Antibacterial and pharmacokinetic properties of Ml4659, a new injectable semisynthetic cephalosporin. J. Antibiotics 41: 377-391, 1988 WATANABE, NA (WOS:A1987G764500003) 1987; 31 KAMACHI, H (WOS:A1990DK69300011) 1990; 43 MOCHIZUKI, H (WOS:A1988Q805400011) 1988; 32 MOCHIZUKI, H (WOS:A1988M634900014) 1988; 41 SANADA, M (WOS:A1988Q737000005) 1988; 14 (WOS:A1993LD99900017.1) 1988 KATSU, K (WOS:A1982PA37700001) 1982; 22 KAMACHI, H (WOS:A1992JB05600025) 1992; 45 NAKAGAWA, S (WOS:A1987J082500025) 1987; 31 NAKAGAWA, S (WOS:A1989AP32900003) 1989; 33 WEI, CC (WOS:A1992JC51100057) 1992; 57 |
| References_xml | – reference: 5) WATANABE, N.; T. NAGASU, K. KATSU & K. KITOH: E-0702, a new cephalosporin, is incorporated into Escherichia coli cells via the to".#-dependent iron transport system. Antimicrob. Agents Chemother. 31: 497 - 504, 1987 – reference: 9) KAMACHI, H.; T. OKITA, H. HOSHI, S. OKUYAMA & T. NAITO: Synthesis of geometrical isomers of 3-(3-acetoxy and 3-carbamoyloxy-l-propenyl)cephalosporins and their structure-activity relationships. J. Antibiotics 45: 998-1001,1992 – reference: 7) MOCHIZUKI, H.; H. YAMADA, Y. OIKAWA, K. MURAKAMI, J. ISHIGURO, H. KOSUZUME, N. AIZAWA & E. MOCHIDA: Bactericidal activity of M14659 enhanced in low-iron environments. Antimicrob. Agents Chemother. 32: 1648-1654,1988 – reference: 3) MOCHIZUKI, H.; Y. OIKAWA, H. YAMADA, S. KUSAKABE, T. SHIIHARA, K. MURAKAMI, K. KATO, J. ISHIGURO & H. KOSUZUME: Antibacterial and pharmacokinetic properties of Ml4659, a new injectable semisynthetic cephalosporin. J. Antibiotics 41: 377-391, 1988 – reference: 8) KAMACHI, H.; M. OKA, Y. NARITA, S. IIMURA, S. ABURAKI, H. YAMASHITA, K. TOMATSU, J. OKUMURA & T. NAITO: Synthesis of a new series of cephalosporins having 3-substituted-ammonio-l-propenyl group as the C-3 side chain.? J. Antibiotics 43: 533-543, 1990 – reference: 2) NAKAGAWA, S.; M. SANADA, K. MATSUDA, N. HAZUMI & N. TANAKA: Biological activity of BO-1236, a new antipseudomonal cephalosporin. Antimicrob. Agents Chemother. 31: 1100 - 1105, 1987 – reference: 4) NAKAGAWA, S.; M. SANADA, K. MATSUDA, T. HASHIZUME, Y. ASAHI, R. USHIJIMA, N. OHTAKE & N. TANAKA: In vitro and in vivo antibacterial activities of BO-1341, a new antipseudomonal cephalosporin. Antimicrob. Agents Chemother. 33: 1423-1427, 1989 – reference: 11) CORBETT, D. F.; C. H. FRIEDRICH & R. SOUTHGATE (Beecham): New aryloxymethyl-7-acylamino-3-cephem derivatives and analogues useful as broad spectrum antibacterials. Jpn. Kokai 152389 ('88), June 24, 1988 – reference: 6) SANADA, M.; T. HASHIZUME, K. MATSUDA, S. NAKAGAWA & N. TANAKA: Mode of action of BO-1341: transport pathway through the outer membrane of Escherichia coli. Drugs Exptl. Clin. Res. 14: 397 - 402, 1988 – reference: 1) KATSU, K.; K. KITOH, M. INOUE & S. MITSUHASHI: In vitro antibacterial activity of E-0702, a new semisynthetic cephalosporin. Antimicrob. Agents Chemother. 22: 181-185, 1982 – reference: 10) WEI, C. C; D. BARTKOVITZ & K. F. WEST: A facile and general synthesis of 3-(acyloxy)cephalosporins. J. Org. Chem. 57: 4027-4030, 1992 – volume: 31 start-page: 1100 year: 1987 ident: WOS:A1987J082500025 article-title: BIOLOGICAL-ACTIVITY OF BO-1236, A NEW ANTIPSEUDOMONAL CEPHALOSPORIN publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY – volume: 32 start-page: 1648 year: 1988 ident: WOS:A1988Q805400011 article-title: BACTERICIDAL ACTIVITY OF M14659 ENHANCED IN LOW-IRON ENVIRONMENTS publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY – volume: 45 start-page: 998 year: 1992 ident: WOS:A1992JB05600025 article-title: SYNTHESIS OF GEOMETRICAL-ISOMERS OF 3-(3-ACETOXY-1-PROPENYL)CEPHALOSPORIN AND 3-(3-CARBAMOYLOXY-1-PROPENYL)CEPHALOSPORIN AND THEIR STRUCTURE-ACTIVITY-RELATIONSHIPS publication-title: JOURNAL OF ANTIBIOTICS – volume: 14 start-page: 397 year: 1988 ident: WOS:A1988Q737000005 article-title: MODE OF ACTION OF BO-1341 - TRANSPORT PATHWAY THROUGH THE OUTER-MEMBRANE OF ESCHERICHIA-COLI publication-title: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH – volume: 22 start-page: 181 year: 1982 ident: WOS:A1982PA37700001 article-title: INVITRO ANTIBACTERIAL ACTIVITY OF E-0702, A NEW SEMI-SYNTHETIC CEPHALOSPORIN publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY – year: 1988 ident: WOS:A1993LD99900017.1 – volume: 33 start-page: 1423 year: 1989 ident: WOS:A1989AP32900003 article-title: INVITRO AND INVIVO ANTIBACTERIAL ACTIVITIES OF BO-1341, A NEW ANTIPSEUDOMONAL CEPHALOSPORIN publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY – volume: 31 start-page: 497 year: 1987 ident: WOS:A1987G764500003 article-title: E-0702, A NEW CEPHALOSPORIN, IS INCORPORATED INTO ESCHERICHIA-COLI-CELLS VIA THE TONB-DEPENDENT IRON TRANSPORT-SYSTEM publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY – volume: 57 start-page: 4027 year: 1992 ident: WOS:A1992JC51100057 article-title: A FACILE AND GENERAL-SYNTHESIS OF 3-(ACYLOXY)CEPHALOSPORINS publication-title: JOURNAL OF ORGANIC CHEMISTRY – volume: 41 start-page: 377 year: 1988 ident: WOS:A1988M634900014 article-title: ANTIBACTERIAL AND PHARMACOKINETIC PROPERTIES OF M14659, A NEW INJECTABLE SEMISYNTHETIC CEPHALOSPORIN publication-title: JOURNAL OF ANTIBIOTICS – volume: 43 start-page: 533 year: 1990 ident: WOS:A1990DK69300011 article-title: SYNTHESIS OF A NEW SERIES OF CEPHALOSPORINS HAVING 3-SUBSTITUTED-AMMONIO-1-PROPENYL GROUP AS THE C-3 SIDE-CHAIN publication-title: JOURNAL OF ANTIBIOTICS |
| SSID | ssj0037378 |
| Score | 1.4098482 |
| Snippet | Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them,... CePhalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them,... Cephalosporins having a catechol through a variety of linkages to the C3 position and a different C7 side chain were prepared. Among them, 3-(catechol-4-... |
| Source | Web of Science |
| SourceID | proquest pubmed pascalfrancis webofscience crossref jstage |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 833 |
| SubjectTerms | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biotechnology & Applied Microbiology Cephalosporins - chemical synthesis Cephalosporins - pharmacology Immunology Life Sciences & Biomedicine Medical sciences Microbial Sensitivity Tests Microbiology Pharmacology & Pharmacy Pharmacology. Drug treatments Science & Technology Structure-Activity Relationship |
| Title | SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN |
| URI | https://www.jstage.jst.go.jp/article/antibiotics1968/46/5/46_5_833/_article/-char/en http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=A1993LD99900017 https://www.ncbi.nlm.nih.gov/pubmed/8514638 https://www.proquest.com/docview/75794907 |
| Volume | 46 |
| WOS | A1993LD99900017 |
| WOSCitedRecordID | wosA1993LD99900017 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | The Journal of Antibiotics, 1993/05/25, Vol.46(5), pp.833-839 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKAGkSQtwmCgz8MO2lS8n98mjSjIRtaVnTsT2gKE4cqQjairYP42fwizmO0zQpBRVeoio9thyfL-diH39B6Ci1qGUnKpUUKzMkneqWlOiOLGXMdnJqMzMvFtwuQtMf6R-ujetW62etamm5oN30x9ZzJf-jVbgHeuWnZP9Bs1WncAN-g37hChqG6046Ht6Eke8Ng2FBEkXCKHhHXIhPA87X6EbBVRDd8LIe1xv45Lw_HPQvIVnv-OSKr1GRjksij28ldYKwKP1xtc4w6HmS65Mg_EPYCpoY0_F0UauS758FEWkUXAcXxGusofpk6L0nnzalRpdkvfyalYfxtJpHGJBQPFfQj_jmFqehDOuWVlUkiN7luqUtFxvH9b1s4XMFGcbKAwt6o03jzjO7gtW4esyubnbLpjVtz74V6oZQUjcFc0yTZnvD_VVFiZwAWDvvQcRcsAjdQXdVSD24sT_7WO1MaZZWevfy-cRBLD62t7-PbB_dL4fRCHvufYHIn1M6PJglc3gVc_ENlW1JztZ4qIh9okfoYal9TAQCH6MWmzxBxwPBen57gqP1Ib75CT7GgzUf-u1T9LmCKQaY4gZM8QqmuH-KmzDFAqaY4BVMcRBi6Ai7Gl7D9BkanXqR60vlVz2kFJLlhZQ6GcTkGdXTTDVtJaFOmmZKnmWpJjsMMhAzZ5pDTSfNNcuwmMoyy2KWnFMKt1NFO0B7k-mEPUfYsGWmZmluJBBYZ7qWMIdqcuIo4Fd0laltpKwmPU5Lynv-5ZWvMaS-XGVxTWWxbsagsjbqVG1mgvDlr9I9octKtjQGdVlwcjaXN8QFmlVS_GglWLI2OmwgoepNh2DFNvU2erNCRgzmn-_pJRM2Xc5jmCEHbKvVRgcCMFXTEnhtdFQHUPX3BtphqnYRc8tZ5IQZixe7df0S7YsqYb5u-QrtLb4v2SFE8gv6uni1fgHz4uK8 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SYNTHESIS+AND+ANTIBACTERIAL+ACTIVITY+OF+CEPHALOSPORINS+HAVING+A+CATECHOL+IN+THE+C3+SIDE-CHAIN&rft.jtitle=Journal+of+antibiotics&rft.au=OKITA%2C+T&rft.au=IMAE%2C+K&rft.au=HASEGAWA%2C+T&rft.au=IMURA%2C+S&rft.date=1993&rft.pub=JAPAN+ANTIBIOT+RES+ASSN&rft.issn=0021-8820&rft.volume=46&rft.issue=5&rft.spage=833&rft.epage=839&rft_id=info:doi/10.7164%2Fantibiotics.46.833&rft_id=info%3Apmid%2F8514638&rft.externalDBID=n%2Fa&rft.externalDocID=A1993LD99900017 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-8820&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-8820&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-8820&client=summon |