Structural rearrangements allow nucleic acid discrimination by type I-D Cascade

• Published in: Nature communications Vol. 13; no. 1; pp. 2829 - 11
• Main Authors: Schwartz, Evan A., McBride, Tess M., Bravo, Jack P. K., Wrapp, Daniel, Fineran, Peter C., Fagerlund, Robert D., Taylor, David W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 631/337/4041/3196; 631/535/1258/1259; Adaptive systems; Binding; CRISPR; CRISPR-Associated Proteins - metabolism; CRISPR-Cas Systems; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA Cleavage; Humanities and Social Sciences; Immune system; multidisciplinary; Nucleic Acids; Phages; Prokaryotes; Proteins; RNA; Science; Science (multidisciplinary); Single-stranded DNA; Substrate inhibition

CRISPR-Cas systems are adaptive immune systems that protect prokaryotes from foreign nucleic acids, such as bacteriophages. Two of the most prevalent CRISPR-Cas systems include type I and type III. Interestingly, the type I-D interference proteins contain characteristic features of both type I and t...