Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes

• Published in: Cellular and molecular life sciences : CMLS Vol. 71; no. 13; pp. 2451 - 2465
• Main Authors: Jobert, Laure, Nilsen, Hilde
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01.07.2014; Springer Nature B.V
• Subjects: Base excision repair; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Damage; Degradation; Deoxyribonucleic acid; DNA; DNA Damage; DNA repair; DNA Repair - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism; Enzymes; Epigenetics; Eukaryotes; eukaryotic cells; Humans; Life Sciences; metabolism; monitoring; Protein Biosynthesis; Proteins; Quality control; Regulatory mechanisms (biology); Review; Ribonucleic acid; RNA; RNA - chemistry; RNA modification; RNA processing; RNA Stability - genetics; SMUG1 protein; translation (genetics); Uracil-DNA Glycosidase - genetics; Uracil-DNA Glycosidase - metabolism; SMUG1; RNA editing; RNA quality control; APE1; Base excision repair; RNA epigenetics

The acquisition of an appropriate set of chemical modifications is required in order to establish correct structure of RNA molecules, and essential for their function. Modification of RNA bases affects RNA maturation, RNA processing, RNA quality control, and protein translation. Some RNA modificatio...