Characterization of phage resistance and phages capable of intestinal decolonization of carbapenem-resistant Klebsiella pneumoniae in mice

• Published in: Communications biology Vol. 5; no. 1; pp. 48 - 14
• Main Authors: Fang, Qingqing, Feng, Yu, McNally, Alan, Zong, Zhiyong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 14/28; 45/22; 45/23; 45/77; 631/326/1321; 631/326/22/1434; 64/60; Animal models; Animals; Anti-Bacterial Agents - pharmacology; Bacteriophages - physiology; Biology; Biomedical and Life Sciences; Carbapenem-Resistant Enterobacteriaceae - virology; Carbapenems - pharmacology; Colonization; Drug resistance; Exopolysaccharides; Intestine; Intestines - virology; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - drug effects; Klebsiella pneumoniae - virology; Life Sciences; Mice; Phages; Polysaccharides; Public health; Resistant mutant; Virome; Virulence

Carbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a severe global health challenge. We isolate and characterize two previously unidentified lytic phages, P24 and P39, with large burst sizes active against ST11 KL64, a major CRKP lineage. P24 and P39 represent species of the genera Prz...