Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis

• Published in: Arthritis research & therapy Vol. 22; no. 1; pp. 1 - 265
• Main Authors: Raschi, Elena, Privitera, Daniela, Bodio, Caterina, Lonati, Paola Adele, Borghi, Maria Orietta, Ingegnoli, Francesca, Meroni, Pier Luigi, Chighizola, Cecilia Beatrice
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 09.11.2020; BioMed Central; BMC
• Subjects: Abnormalities; Antibodies; Antigens; Arthritis; Autoantibodies; Biopsy; Care and treatment; Cell culture; Deoxyribonucleic acid; Development and progression; Disease; DNA; Endothelial cells; Endothelium; Fibroblasts; Fibrosis; Immune complexes; Immune response; Lupus; Observations; Pathogenesis; Penicillin; Polyethylene glycol; RNA polymerase; Scleroderma; Scleroderma (Disease); Systemic sclerosis; Toll-like receptors; Tumor necrosis factor-TNF; Italy; United States > US; Germany

Abstract Background Consistently with their diagnostic and prognostic value, autoantibodies specific for systemic sclerosis (SSc) embedded in immune complexes (ICs) elicited a pro-inflammatory and pro-fibrotic cascade in healthy skin fibroblasts, engaging Toll-like receptors (TLRs) via their nucleic...