Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

• Published in: Nature communications Vol. 10; no. 1; pp. 2342 - 9
• Main Authors: Kirchdoerfer, Robert N., Ward, Andrew B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.05.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 631/326/596/2078; 631/45/535/1258/1259; 82/83; Catalysis; Coenzymes - ultrastructure; Coronaviridae; Coronaviruses; COVID-19; Cryoelectron Microscopy; DNA-Directed RNA Polymerases - ultrastructure; Drug development; Electron microscopy; Genome, Viral; Genomes; Humanities and Social Sciences; Kinases; multidisciplinary; Respiratory diseases; Ribonucleic acid; RNA; RNA polymerase; Science; Science (multidisciplinary); Severe acute respiratory syndrome; Severe acute respiratory syndrome-related coronavirus - metabolism; Severe acute respiratory syndrome-related coronavirus - ultrastructure; Structural proteins; Transcription; Viral Nonstructural Proteins - ultrastructure

Recent history is punctuated by the emergence of highly pathogenic coronaviruses such as SARS- and MERS-CoV into human circulation. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (nsp) responsible for the replication and trans...