The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of primary Sjögren’s syndrome

• Published in: Arthritis research & therapy Vol. 24; no. 1; pp. 1 - 13
• Main Authors: Peng, Yu, Wu, Xunyao, Zhang, Shulan, Deng, Chuiwen, Zhao, Lidan, Wang, Mu, Wu, Qingjun, Yang, Huaxia, Zhou, Jiaxin, Peng, Linyi, Luo, Xuan, Chen, Yingying, Wang, Anqi, Xiao, Qiufeng, Zhang, Wen, Zhao, Yan, Zeng, Xiaofeng, Fei, Yunyun
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 19.07.2022; BioMed Central; BMC
• Subjects: Analysis; Antibodies; Arthritis; Autoimmune diseases; Biological response modifiers; Care and treatment; Cell culture; Diagnosis; Disease; Flow cytometry; Gene expression; Granulocytes; Health aspects; Hospitals; Interferon; Medical research; Mitochondrial damage; Neutrophil extracellular traps; Neutrophils; Pathogenesis; Pathogens; Plasma; Primary Sjögren’s syndrome; Reactive oxygen species; Sjogren's syndrome; Type I interferon; China

Objective Neutrophils and aberrant NETosis have been implicated in the pathogenesis of diverse autoimmune diseases; however, their roles in primary Sjögren's syndrome (pSS) remain unclear. We aimed to reveal the potential roles of neutrophils and neutrophil extracellular traps (NETs) in pSS. Me...