Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

• Published in: Scientific reports Vol. 7; no. 1; pp. 2093 - 12
• Main Authors: Han, Kim, Hassanzadeh, Shahin, Singh, Komudi, Menazza, Sara, Nguyen, Tiffany T., Stevens, Mark V., Nguyen, An, San, Hong, Anderson, Stasia A., Lin, Yongshun, Zou, Jizhong, Murphy, Elizabeth, Sack, Michael N.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/89; 59/57; 631/337; 64/60; 692/4019/592/1540; 82/29; 82/80; 96/31; Animals; Aorta; Apoptosis; Cardiomyocytes; Cardiomyopathy; Cardiomyopathy, Dilated - metabolism; Cardiomyopathy, Dilated - pathology; CCAAT/enhancer-binding protein; Cell death; Cell Line; Cell Line, Tumor; Dilated cardiomyopathy; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Heart; Heart diseases; HEK293 Cells; Humanities and Social Sciences; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Male; Mice; Mice, Inbred C57BL; Mortality; multidisciplinary; Myocardium; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; Parkin protein; Post-translation; Proteasomes; Rodents; Science; Science (multidisciplinary); Transcription Factor CHOP - metabolism; Tunicamycin; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ventricle; Ventricular Remodeling

The regulatory control of cardiac endoplasmic reticulum (ER) stress is incompletely characterized. As ER stress signaling upregulates the E3-ubiquitin ligase Parkin, we investigated the role of Parkin in cardiac ER stress. Parkin knockout mice exposed to aortic constriction-induced cardiac pressure-...