Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis

• Published in: Cell death & disease Vol. 12; no. 4; pp. 405 - 13
• Main Authors: Feng, Lifeng, Chen, Miaoqin, Li, Yiling, Li, Muchun, Hu, Shiman, Zhou, Bingluo, Zhu, Liyuan, Yu, Lei, Zhou, Qiyin, Tan, Linghui, An, Huimin, Wang, Xian, Jin, Hongchuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.04.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/51; 42/89; 631/337/458; 631/67; 64/60; 82/58; Acetylation; Acetyltransferase; Animals; Antibodies; Autophagy - physiology; Biochemistry; Biomedical and Life Sciences; Carcinogenesis; Carcinogenesis - metabolism; Carcinoma, Hepatocellular - metabolism; Cell Biology; Cell Culture; Hepatocellular carcinoma; Immunology; Kelch-Like ECH-Associated Protein 1 - metabolism; Life Sciences; Liver cancer; Liver Neoplasms - metabolism; Lysine; Mice; Mice, Inbred BALB C; NF-κB protein; p62 Protein; Proteasomes; Protein Processing, Post-Translational - physiology; Signal Transduction - physiology; SIRT1 protein; Sirtuin 1 - metabolism; Tumors; Ubiquitin-protein ligase; Ubiquitination

p62/SQSTM1 is frequently up-regulated in many cancers including hepatocellular carcinoma. Highly expressed p62 promotes hepato-carcinogenesis by activating many signaling pathways including Nrf2, mTORC1, and NFκB signaling. However, the underlying mechanism for p62 up-regulation in hepatocellular ca...