Genomic programming of IRF4-expressing human Langerhans cells

• Published in: Nature communications Vol. 11; no. 1; p. 313
• Main Authors: Sirvent, Sofia, Vallejo, Andres F., Davies, James, Clayton, Kalum, Wu, Zhiguo, Woo, Jeongmin, Riddell, Jeremy, Chaudhri, Virendra K., Stumpf, Patrick, Nazlamova, Liliya Angelova, Wheway, Gabrielle, Rose-Zerilli, Matthew, West, Jonathan, Pujato, Mario, Chen, Xiaoting, Woelk, Christopher H., MacArthur, Ben, Ardern-Jones, Michael, Friedmann, Peter S., Weirauch, Matthew T., Singh, Harinder, Polak, Marta E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.01.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/31; 13/89; 38/39; 38/91; 631/250/21; 631/250/2502; 631/250/2504/133; 631/250/2504/133/1593; Activator protein 1; Antigen presentation; Antigen Presentation - genetics; Antigen processing; Antigens; Attenuation; Basic-Leucine Zipper Transcription Factors - metabolism; Cell Movement; Chromatin; CRISPR; CRISPR-Cas Systems; Cytokines; Cytokines - metabolism; Editing; Epidermis; ETS protein; Gene Editing; Gene expression; Gene Expression Profiling; Genes; Genomics; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Humanities and Social Sciences; Humans; Immunogenicity; Inflammation; Inflammatory response; Interferon regulatory factor 4; Interferon Regulatory Factors - genetics; Interferon Regulatory Factors - metabolism; Langerhans cells; Langerhans Cells - immunology; Langerhans Cells - metabolism; Major histocompatibility complex; Maturation; multidisciplinary; NF-kappa B - metabolism; NF-κB protein; Oxidative stress; Proto-Oncogene Proteins - metabolism; PU.1 protein; Regulatory sequences; Repressor Proteins - metabolism; Science; Science (multidisciplinary); Skin; Trans-Activators - metabolism; Transcription factors; Transcription, Genetic; Transcriptional Activation; Tumor necrosis factor; Up-Regulation

Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in skin, but the genomic states and transcription factors (TF) regulating these context-specific responses are unclear. Bulk and single-cell transcriptional profiling demonstrates that human migratory LCs are robustly progr...