Distinct methylation levels of mature microRNAs in gastrointestinal cancers

• Published in: Nature communications Vol. 10; no. 1; pp. 3888 - 7
• Main Authors: Konno, Masamitsu, Koseki, Jun, Asai, Ayumu, Yamagata, Akira, Shimamura, Teppei, Motooka, Daisuke, Okuzaki, Daisuke, Kawamoto, Koichi, Mizushima, Tsunekazu, Eguchi, Hidetoshi, Takiguchi, Shuji, Satoh, Taroh, Mimori, Koshi, Ochiya, Takahiro, Doki, Yuichiro, Ofusa, Ken, Mori, Masaki, Ishii, Hideshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.08.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 38; 38/91; 631/208/68/2486; 631/67/1857; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Cancer; Cell Line, Tumor; Diagnostic systems; Epigenomics; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - metabolism; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humanities and Social Sciences; Humans; Methylation; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Molecular Dynamics Simulation; multidisciplinary; Pancreatic cancer; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Target recognition

The biological significance of micro (mi)RNAs has traditionally been evaluated according to their RNA expression levels based on the assumption that miRNAs recognize and regulate their targets in an unvarying fashion. Here we show that a fraction of mature miRNAs including miR-17-5p, -21-5p, and -20...