Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism

• Published in: Nature communications Vol. 10; no. 1; pp. 4971 - 17
• Main Authors: Huang, Fengjie, Zheng, Xiaojiao, Ma, Xiaohui, Jiang, Runqiu, Zhou, Wangyi, Zhou, Shuiping, Zhang, Yunjing, Lei, Sha, Wang, Shouli, Kuang, Junliang, Han, Xiaolong, Wei, Meilin, You, Yijun, Li, Mengci, Li, Yitao, Liang, Dandan, Liu, Jiajian, Chen, Tianlu, Yan, Chao, Wei, Runmin, Rajani, Cynthia, Shen, Chengxing, Xie, Guoxiang, Bian, Zhaoxiang, Li, Houkai, Zhao, Aihua, Jia, Wei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.10.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/51; 38/77; 45; 631/326/2565/2134; 631/443/319/1642; 631/443/319/2723; 64/60; 692/4020/2741/2135; 82/80; Adult; Amidohydrolases - metabolism; Animals; Bile; Bile acids; Bile Acids and Salts - metabolism; Catechin - analogs & derivatives; Catechin - pharmacology; Chenodeoxycholic acid; Chenodeoxycholic Acid - metabolism; Cholesterol; Cholesterol - metabolism; Diet, High-Fat; Digestive system; Fecal Microbiota Transplantation; Fermented Foods and Beverages; Fibroblast Growth Factors - drug effects; Fibroblast Growth Factors - metabolism; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - genetics; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Gene expression; Gut microbiota; Humanities and Social Sciences; Humans; Hydrolase; Hypercholesterolemia; Hypercholesterolemia - metabolism; Hyperlipidemia; Ileum - drug effects; Ileum - metabolism; Intestinal microflora; Intestine; Lipid metabolism; Lipids; Lipogenesis; Lipogenesis - drug effects; Lipolysis; Liver; Liver - drug effects; Liver - metabolism; Male; Metabolomics; Mice; Microbiota; multidisciplinary; Pigments; Plant Extracts - pharmacology; Receptors, Cytoplasmic and Nuclear - drug effects; Receptors, Cytoplasmic and Nuclear - metabolism; RNA, Ribosomal, 16S; Science; Science (multidisciplinary); Signal Transduction; Signaling; Tea; Young Adult

Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...