Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

• Published in: Communications biology Vol. 4; no. 1; pp. 597 - 9
• Main Authors: Chiba, Shiho, Frey, Steven J., Halfmann, Peter J., Kuroda, Makoto, Maemura, Tadashi, Yang, Jie E., Wright, Elizabeth R., Kawaoka, Yoshihiro, Kane, Ravi S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 631/250/590; 692/699/255; Animals; Antibodies, Neutralizing - biosynthesis; Antibodies, Viral - biosynthesis; Biology; Biomedical and Life Sciences; Coat protein; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - genetics; COVID-19 Vaccines - immunology; Drug Delivery Systems; Female; Humans; Immunization; Immunization - methods; Levivirus - genetics; Levivirus - immunology; Life Sciences; Mesocricetus; Microscopy, Electron, Transmission; Models, Animal; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - ultrastructure; Nanotechnology; Pandemics; Pandemics - prevention & control; Phages; Protein Engineering; Rodents; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - administration & dosage; Spike Glycoprotein, Coronavirus - immunology; Vaccines; Vaccines, Combined - administration & dosage; Vaccines, Combined - genetics; Vaccines, Combined - immunology; Vaccines, Virus-Like Particle - administration & dosage; Vaccines, Virus-Like Particle - genetics; Vaccines, Virus-Like Particle - immunology

The COVID-19 pandemic continues to wreak havoc as worldwide SARS-CoV-2 infection, hospitalization, and death rates climb unabated. Effective vaccines remain the most promising approach to counter SARS-CoV-2. Yet, while promising results are emerging from COVID-19 vaccine trials, the need for multipl...