Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

• Published in: Nature communications Vol. 13; no. 1; pp. 2023 - 16
• Main Authors: Lissa, Delphine, Takahashi, Nobuyuki, Desai, Parth, Manukyan, Irena, Schultz, Christopher W., Rajapakse, Vinodh, Velez, Moises J., Mulford, Deborah, Roper, Nitin, Nichols, Samantha, Vilimas, Rasa, Sciuto, Linda, Chen, Yuanbin, Guha, Udayan, Rajan, Arun, Atkinson, Devon, El Meskini, Rajaa, Weaver Ohler, Zoe, Thomas, Anish
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 38; 38/91; 45; 45/23; 631/67/1612/2143; 631/67/70; 692/4028/67/1612/2143; 692/53; ASCL1 protein; Beta2 protein; Cell differentiation; Chemical compounds; Chemotherapy; Chromatin; DNA damage; Gene Expression Regulation, Neoplastic; Genomics; Heterogeneity; Histology; Humanities and Social Sciences; Humans; Immunotherapy; Lung cancer; Lung Neoplasms - pathology; Math1 protein; Metastases; Metastasis; multidisciplinary; Mutation; Neuroendocrine Tumors - genetics; Patients; Pharmacology; Phenotypes; Science; Science (multidisciplinary); Small cell lung carcinoma; Small Cell Lung Carcinoma - pathology; Transcription; Transcription Factors - metabolism; Transcriptomes; Transcriptomics; Tumors; Xenografts; Xenotransplantation; Yes-associated protein

Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key transcription regulators have recently been proposed in cell lines and limited number of primary tumors. The clinical and biological implications of neuroendocrine (NE) subtypes in metastatic SCLC, and the extent to...