Linked dimensions of psychopathology and connectivity in functional brain networks

• Published in: Nature communications Vol. 9; no. 1; pp. 3003 - 14
• Main Authors: Xia, Cedric Huchuan, Ma, Zongming, Ciric, Rastko, Gu, Shi, Betzel, Richard F., Kaczkurkin, Antonia N., Calkins, Monica E., Cook, Philip A., García de la Garza, Angel, Vandekar, Simon N., Cui, Zaixu, Moore, Tyler M., Roalf, David R., Ruparel, Kosha, Wolf, Daniel H., Davatzikos, Christos, Gur, Ruben C., Gur, Raquel E., Shinohara, Russell T., Bassett, Danielle S., Satterthwaite, Theodore D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 59/36; 59/57; 631/114/116; 631/114/116/1925; 692/699/476; Abnormalities; Adolescent; Adult; Biomarkers; Brain; Brain - physiology; Child; Cohort Studies; Correlation analysis; Diagnostic systems; Fear; Female; Gender aspects; Humanities and Social Sciences; Humans; Male; Mental disorders; Mood; Morbidity; multidisciplinary; Multivariate Analysis; Nerve Net - physiology; Neural networks; Psychiatry; Psychopathology; Psychosis; Reproducibility of Results; Science; Science (multidisciplinary); Sex Characteristics; Sex differences; Young Adult

Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical co...