Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury

• Published in: Cell death & disease Vol. 13; no. 3; pp. 271 - 11
• Main Authors: Lin, Feiyan, Chen, Wenyi, Zhou, Jiahang, Zhu, Jiaqi, Yao, Qigu, Feng, Bing, Feng, Xudong, Shi, Xiaowei, Pan, Qiaoling, Yu, Jiong, Li, Lanjuan, Cao, Hongcui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.03.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/100; 13/31; 13/51; 59/5; 64/60; 692/308/1426; 692/699/1503/1607/2749; 82/1; 82/58; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Carbon tetrachloride; CD44 antigen; Cell Biology; Cell Culture; Cell death; Exosomes; Exosomes - metabolism; Ferroptosis; Hepatocytes; Hepatocytes - metabolism; Immunology; Life Sciences; Lipid peroxidation; Liver; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Mice; mRNA; Prostaglandin endoperoxide synthase; Remission; Stem cell transplantation; Stem cells

Mesenchymal stem cells (MSCs) have attracted interest for their potential to alleviate liver injury. Here, the protective effect of MSCs on carbon tetrachloride (CCl 4 )-induced acute liver injury (ALI) was investigated. In this study, we illustrated a novel mechanism that ferroptosis, a newly recog...