An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis - Wang, Yifeng; Gunewardena, Sumedha; Li, Feng; Matye, David J.; Chen, Cheng; Chao, Xiaojuan; Jung, Taeyoon; Zhang, Yuxia; Czerwiński, Maciej; Ni, Hong-Min; Ding, Wen-Xing; Li, Tiangang (Nature communications, 2020)
Keywords: 14/19; 49/15; 631/443; 631/45; 631/80; 64/60; 96/95; Acids; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - antagonists & inhibitors; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism; Bile; Bile Acids and Salts - metabolism; Biosynthesis; Cell Line; Cholesterol; Cholesterol - metabolism; Cholesterol 7-alpha-Hydroxylase - metabolism; Diet; Diet, Western - adverse effects; Disease Models, Animal; Fibroblast growth factors; Fibroblast Growth Factors - metabolism; Growth factors; Hep G2 Cells; Hepatocytes; Homeostasis; Humanities and Social Sciences; Humans; Hydroxylase; Hypercholesterolemia; Hypercholesterolemia - etiology; Hypercholesterolemia - metabolism; Hypercholesterolemia - prevention & control; Ileum - drug effects; Ileum - metabolism; Intestine; Liver; Liver - drug effects; Liver - metabolism; Localization; Male; Mice; multidisciplinary; Nuclear transport; Organic Anion Transporters, Sodium-Dependent - antagonists & inhibitors; Phosphorylation; Science; Science (multidisciplinary); Signaling; Symporters - antagonists & inhibitors; Synthesis; TOR protein; Translocation