An integrative ENCODE resource for cancer genomics

• Published in: Nature communications Vol. 11; no. 1; pp. 3696 - 11
• Main Authors: Zhang, Jing, Lee, Donghoon, Dhiman, Vineet, Jiang, Peng, Xu, Jie, McGillivray, Patrick, Yang, Hongbo, Liu, Jason, Meyerson, William, Clarke, Declan, Gu, Mengting, Li, Shantao, Lou, Shaoke, Xu, Jinrui, Lochovsky, Lucas, Ung, Matthew, Ma, Lijia, Yu, Shan, Cao, Qin, Harmanci, Arif, Yan, Koon-Kiu, Sethi, Anurag, Gürsoy, Gamze, Schoenberg, Michael Rutenberg, Rozowsky, Joel, Warrell, Jonathan, Emani, Prashant, Yang, Yucheng T., Galeev, Timur, Kong, Xiangmeng, Liu, Shuang, Li, Xiaotong, Krishnan, Jayanth, Feng, Yanlin, Rivera-Mulia, Juan Carlos, Adrian, Jessica, Broach, James R, Bolt, Michael, Moran, Jennifer, Fitzgerald, Dominic, Dileep, Vishnu, Liu, Tingting, Mei, Shenglin, Sasaki, Takayo, Trevilla-Garcia, Claudia, Wang, Su, Wang, Yanli, Zang, Chongzhi, Wang, Daifeng, Klein, Robert J., Snyder, Michael, Gilbert, David M., Yip, Kevin, Cheng, Chao, Yue, Feng, Liu, X. Shirley, White, Kevin P., Gerstein, Mark
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.07.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 45/15; 45/23; 45/47; 45/91; 49/15; 49/47; 631/114/2114; 631/114/2401; 631/208/69; Annotations; Cancer; Cell Line, Tumor; Cell Transformation, Neoplastic - genetics; CRISPR; Crosstalk; Databases, Genetic; Datasets; Encyclopedias; Gene Regulatory Networks; Genomes; Genomics; Hierarchies; Humanities and Social Sciences; Humans; multidisciplinary; Mutation - genetics; Myc protein; Neoplasms - genetics; Regulators; Reproducibility of Results; RNA-binding protein; Science; Science (multidisciplinary); siRNA; Transcription factors; Transcription Factors - metabolism; Tumorigenesis; Tumors; Workflow

ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds of cell types, providing a universal annotation for genome interpretation. However, for particular applications, it may be advantageous to use a customized annotation. Here, we develop such a custom anno...