Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy

• Published in: Nature communications Vol. 10; no. 1; pp. 1704 - 14
• Main Authors: Zhang, Wenjia, Hu, Xianglong, Shen, Qi, Xing, Da
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.04.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 14/1; 14/19; 631/154; 631/67; 639/638/455/952; 692/699/67; Amplification; Animals; Antineoplastic Agents - chemistry; Apoptosis; Camptothecin; Camptothecin - chemistry; Cancer; Cell Line, Tumor; Chemotherapy; Drug delivery systems; Drug Liberation; Female; Flow Cytometry; Humanities and Social Sciences; Humans; Life span; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Mitochondria; Mitochondria - metabolism; multidisciplinary; Nanomedicine - methods; Nanotechnology; Neoplasms - metabolism; Oxidative Stress; Oxygen; Photochemotherapy; Photodynamic therapy; Precision medicine; Prodrugs; Reactive oxygen species; Reactive Oxygen Species - metabolism; Science; Science (multidisciplinary)

Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In situ mitochondrial ROS amplification is a promising strategy to enhance cancer therapy. Here we report cancer cell and...