p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs

• Published in: Cell death discovery Vol. 8; no. 1; pp. 502 - 11
• Main Authors: Yamashita, Gai, Takano, Naoharu, Kazama, Hiromi, Tsukahara, Kiyoaki, Miyazawa, Keisuke
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.12.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/67/1059/2326; 631/67/1059/99; 631/80/39/2346; 631/80/82; Antibiotics; Apoptosis; Autophagy; Azithromycin; Biochemistry; Biomedical and Life Sciences; Carboplatin; Cathepsins; Cell Biology; Cell Cycle Analysis; Cell death; Cholesterol; Cytoplasm; Deoxyribonucleic acid; DNA; DNA damage; Doxorubicin; Drugs; Etoposide; Hydroxychloroquine; Life Sciences; Lysosomes; Macromolecules; Niemann-Pick disease; Npc1 protein; Organelles; Stem Cells; TOR protein

Lysosomes are single-membraned organelles that mediate the intracellular degradation of macromolecules. Various stress can induce lysosomal membrane permeabilization (LMP), translocating intralysosomal components, such as cathepsins, to the cytoplasm, which induces lysosomal-dependent cell death (LD...