Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats - Perry, Rachel J.; Rabin-Court, Aviva; Song, Joongyu D.; Cardone, Rebecca L.; Wang, Yongliang; Kibbey, Richard G.; Shulman, Gerald I. (Nature communications, 2019)
Keywords: 59; 631/443/319; 631/443/319/1642; 631/443/319/2723; 692/163/2743; Adipose tissue; Animals; Antidiabetics; Benzhydryl Compounds - adverse effects; Catecholamine; Catecholamines; Corticosterone; Dehydration; Dehydration - complications; Dehydration - pathology; Depletion; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - pathology; Diabetic ketoacidosis; Disease Models, Animal; Furosemide; Glucagon; Glucocorticoids - metabolism; Glucose; Glucose - metabolism; Glucose transport; Glucosides - adverse effects; Humanities and Social Sciences; Humans; Inhibitors; Insulin - metabolism; Ketoacidosis; Ketogenesis; Ketosis - chemically induced; Ketosis - etiology; Ketosis - pathology; Lipolysis; Lipolysis - drug effects; Liver - drug effects; Liver - metabolism; Male; multidisciplinary; Protein transport; Proteins; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1 - metabolism; Rodents; Science; Science (multidisciplinary); Secretion; Sodium; Sodium-glucose cotransporter; Sodium-Glucose Transporter 2 Inhibitors - adverse effects