Lipidomic profiling of human serum enables detection of pancreatic cancer

• Published in: Nature communications Vol. 13; no. 1; pp. 124 - 16
• Main Authors: Wolrab, Denise, Jirásko, Robert, Cífková, Eva, Höring, Marcus, Mei, Ding, Chocholoušková, Michaela, Peterka, Ondřej, Idkowiak, Jakub, Hrnčiarová, Tereza, Kuchař, Ladislav, Ahrends, Robert, Brumarová, Radana, Friedecký, David, Vivo-Truyols, Gabriel, Škrha, Pavel, Škrha, Jan, Kučera, Radek, Melichar, Bohuslav, Liebisch, Gerhard, Burkhardt, Ralph, Wenk, Markus R., Cazenave-Gassiot, Amaury, Karásek, Petr, Novotný, Ivo, Greplová, Kristína, Hrstka, Roman, Holčapek, Michal
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 140/58; 49; 631/67/1504/1713; 631/67/1857; 639/638/11/296; 639/638/11/872; 692/53/2421; Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Blood; Body fluids; CA-19-9 Antigen - blood; Cancer; Cancer screening; Case-Control Studies; Ceramides - blood; Data analysis; Female; Humanities and Social Sciences; Humans; Lipid metabolism; Lipid Metabolism - genetics; Lipidomics - methods; Lipids; Lysophosphatidylcholines - blood; Male; Medical prognosis; Medical screening; multidisciplinary; Multivariate Analysis; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Prognosis; Proportional Hazards Models; Science; Science (multidisciplinary); Sensitivity and Specificity; Serum lipids; Spectrometry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingomyelins - blood; Statistical analysis; Statistical methods; Tumor cells; Tumors

Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body fluids may improve the survival time prognosis of patients, who are often diagnosed too late at an incurable stage. Several studies report the dysregulation of lipid metabolism in tumor cells, suggesting that chang...