Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma

• Published in: Scientific reports Vol. 7; no. 1; pp. 6235 - 11
• Main Authors: Chiang, Shang-Lun, Velmurugan, Bharath Kumar, Chung, Chia-Min, Lin, Shu-Hui, Wang, Zhi-Hong, Hua, Chun-Hung, Tsai, Ming-Hsui, Kuo, Tzer-Min, Yeh, Kun-Tu, Chang, Pei-Ying, Yang, Yi-Hsin, Ko, Ying-Chin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.07.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/51; 13/95; 64/60; 692/308/2778; 692/4028/67/2195; 692/699/67/1536/1665; 82/29; 82/80; Adhesion; Apoptosis; Celecoxib; Cell adhesion & migration; Cell adhesion molecules; Cyclooxygenase-2; Epidermal growth factor receptors; Focal adhesion kinase; Humanities and Social Sciences; Integrins; Lymph nodes; Mesenchyme; Metastases; Mobility; multidisciplinary; Oral cancer; Oral squamous cell carcinoma; Population studies; Prevention; Science; Science (multidisciplinary); Snail protein; Squamous cell carcinoma; Transcription factors; Tumors; Vimentin; Xenografts; β-Catenin

Overexpression of cyclooxygenase-2 in oral cancer increases lymph node metastasis and is associated with a poor prognosis. The potential of celecoxib (CXB) use is reported in cancer treatment by inhibiting proliferation through apoptosis, but the effects on the epithelial-mesenchymal transition (EMT...