Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy

• Published in: Scientific reports Vol. 11; no. 1; pp. 1909 - 11
• Main Authors: Su, Chia-Hao, Hsu, Yung-Chien, Thangudu, Suresh, Chen, Wei-Yu, Huang, Yu-Ting, Yu, Chun-Chieh, Shih, Ya-Hsueh, Wang, Ching-Jen, Lin, Chun-Liang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/245; 692/4022; 692/4022/1585/104; Animals; Biopsy; Contrast Media - pharmacology; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - diagnostic imaging; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - pathology; Diabetic Nephropathies - diagnostic imaging; Diabetic Nephropathies - genetics; Diabetic Nephropathies - physiopathology; Diabetic nephropathy; Diffusion coefficient; Diffusion Magnetic Resonance Imaging; Disease Progression; Fibrosis; Fibrosis - diagnosis; Fibrosis - diagnostic imaging; Fibrosis - genetics; Fibrosis - pathology; Humanities and Social Sciences; Humans; Kidney - diagnostic imaging; Kidney - physiopathology; Kidney diseases; Kidneys; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic - genetics; MicroRNAs - genetics; Middle Aged; multidisciplinary; Nephropathy; Perfusion; Podocytes - metabolism; Podocytes - pathology; Renal failure; Renal function; Renal Insufficiency, Chronic - diagnostic imaging; Renal Insufficiency, Chronic - genetics; Renal Insufficiency, Chronic - physiopathology; Science; Science (multidisciplinary); Streptozocin; Transgenic mice

Diabetic nephropathy (DN) is one of the major leading cause of kidney failure. To identify the progression of chronic kidney disease (CKD), renal function/fibrosis is playing a crucial role. Unfortunately, lack of sensitivities/specificities of available clinical biomarkers are key major issues for...